(30 nodes) Fanconi Anemia Pathway network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fanci	FA complementation group I. (1276 aa)
	fancd2	FA complementation group D2. (1235 aa)
	POLN	DNA polymerase nu. (614 aa)
	LOC102232085	NTF2 domain-containing protein. (130 aa)
	LOC102221827	Uncharacterized protein. (358 aa)
	nutf2	Nuclear transport factor 2. (103 aa)
	fan1	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (945 aa)
	fancg	FA complementation group G. (618 aa)
	fancm	Uncharacterized protein. (1911 aa)
	dclre1a	DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae). (893 aa)
	LOC102231709	Ubiquitin-conjugating enzyme E2T (putative). (194 aa)
	EME2	ERCC4 domain-containing protein. (438 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (617 aa)
	fance	FA complementation group E. (523 aa)
	FAAP100	FA core complex associated protein 100. (819 aa)
	eme1	Essential meiotic structure-specific endonuclease 1. (536 aa)
	Cenpx	Uncharacterized protein. (63 aa)
	helq	Helicase, POLQ like. (992 aa)
	fancc	FA complementation group C. (588 aa)
	fancf	FA complementation group F. (351 aa)
	faap24	FA core complex associated protein 24. (217 aa)
	LOC102233862	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (285 aa)
	ENSXMAP00000025468	Uncharacterized protein. (223 aa)
	slx4	BTB domain-containing protein. (1245 aa)
	fancl	FA complementation group L. (410 aa)
	LOC102220240	Centromere protein S. (155 aa)
	gen1	Uncharacterized protein. (897 aa)
	hes1	Hairy-related 6. (277 aa)
	hes4	Hairy-related 9. (287 aa)
	fancb	FA complementation group B. (842 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cenpx	FAAP100	ENSXMAP00000012359	ENSXMAP00000011163	Uncharacterized protein.	FA core complex associated protein 100.	0.877
Cenpx	LOC102220240	ENSXMAP00000012359	ENSXMAP00000028468	Uncharacterized protein.	Centromere protein S.	0.951
Cenpx	LOC102221827	ENSXMAP00000012359	ENSXMAP00000004445	Uncharacterized protein.	Uncharacterized protein.	0.800
Cenpx	LOC102231709	ENSXMAP00000012359	ENSXMAP00000008248	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2T (putative).	0.850
Cenpx	faap24	ENSXMAP00000012359	ENSXMAP00000023062	Uncharacterized protein.	FA core complex associated protein 24.	0.934
Cenpx	fancb	ENSXMAP00000012359	ENSXMAP00000040747	Uncharacterized protein.	FA complementation group B.	0.885
Cenpx	fancc	ENSXMAP00000012359	ENSXMAP00000015741	Uncharacterized protein.	FA complementation group C.	0.879
Cenpx	fance	ENSXMAP00000012359	ENSXMAP00000010464	Uncharacterized protein.	FA complementation group E.	0.846
Cenpx	fancf	ENSXMAP00000012359	ENSXMAP00000020264	Uncharacterized protein.	FA complementation group F.	0.871
Cenpx	fancg	ENSXMAP00000012359	ENSXMAP00000007520	Uncharacterized protein.	FA complementation group G.	0.871
Cenpx	fanci	ENSXMAP00000012359	ENSXMAP00000000977	Uncharacterized protein.	FA complementation group I.	0.935
Cenpx	fancl	ENSXMAP00000012359	ENSXMAP00000028436	Uncharacterized protein.	FA complementation group L.	0.887
Cenpx	fancm	ENSXMAP00000012359	ENSXMAP00000007734	Uncharacterized protein.	Uncharacterized protein.	0.977
Cenpx	hes1	ENSXMAP00000012359	ENSXMAP00000038996	Uncharacterized protein.	Hairy-related 6.	0.800
Cenpx	hes4	ENSXMAP00000012359	ENSXMAP00000039649	Uncharacterized protein.	Hairy-related 9.	0.800
EME2	ENSXMAP00000025468	ENSXMAP00000009907	ENSXMAP00000025468	ERCC4 domain-containing protein.	Uncharacterized protein.	0.478
EME2	LOC102233862	ENSXMAP00000009907	ENSXMAP00000024272	ERCC4 domain-containing protein.	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	0.470
EME2	dclre1a	ENSXMAP00000009907	ENSXMAP00000008159	ERCC4 domain-containing protein.	DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae).	0.443
EME2	eme1	ENSXMAP00000009907	ENSXMAP00000011572	ERCC4 domain-containing protein.	Essential meiotic structure-specific endonuclease 1.	0.967
EME2	faap24	ENSXMAP00000009907	ENSXMAP00000023062	ERCC4 domain-containing protein.	FA core complex associated protein 24.	0.635