15 items (Xiphophorus maculatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	greb1	Growth regulating estrogen receptor binding 1. (1993 aa)
	LOC102225323	Mothers against decapentaplegic homolog. (563 aa)
	tcf21	Transcription factor 21. (175 aa)
	gdnf	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (254 aa)
	ctnnbip1	Catenin, beta interacting protein 1. (81 aa)
	SMAD4	Mothers against decapentaplegic homolog. (512 aa)
	LOC102217141	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (158 aa)
	fgf1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (167 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	ILK	Integrin linked kinase. (452 aa)
	LOC102228719	Mothers against decapentaplegic homolog. (503 aa)
	LOC102235611	WT1 transcription factor a. (429 aa)
	LOC102228512	Transmembrane protein 59-like. (340 aa)
	wt1	WT1 transcription factor b. (422 aa)
	LOC102231522	Uncharacterized protein. (452 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ILK	LOC102231522	ENSXMAP00000005043	ENSXMAP00000017808	Integrin linked kinase.	Uncharacterized protein.	0.900
LOC102228719	SMAD4	ENSXMAP00000005074	ENSXMAP00000031130	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.900
LOC102231522	ILK	ENSXMAP00000017808	ENSXMAP00000005043	Uncharacterized protein.	Integrin linked kinase.	0.900
LOC102235611	tcf21	ENSXMAP00000005168	ENSXMAP00000024353	WT1 transcription factor a.	Transcription factor 21.	0.444
SMAD4	LOC102228719	ENSXMAP00000031130	ENSXMAP00000005074	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.900
tcf21	LOC102235611	ENSXMAP00000024353	ENSXMAP00000005168	Transcription factor 21.	WT1 transcription factor a.	0.444
tcf21	wt1	ENSXMAP00000024353	ENSXMAP00000014254	Transcription factor 21.	WT1 transcription factor b.	0.444
wt1	tcf21	ENSXMAP00000014254	ENSXMAP00000024353	WT1 transcription factor b.	Transcription factor 21.	0.444