node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LOC102220683 | ptges3 | ENSXMAP00000010651 | ENSXMAP00000041292 | Prostaglandin E synthase 3a (cytosolic). | Prostaglandin E synthase 3b (cytosolic). | 0.902 |
LOC102220683 | tert | ENSXMAP00000010651 | ENSXMAP00000016432 | Prostaglandin E synthase 3a (cytosolic). | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. | 0.581 |
LOC102232687 | RPA1 | ENSXMAP00000006245 | ENSXMAP00000010389 | Uncharacterized protein. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.474 |
LOC102232687 | ctc1 | ENSXMAP00000006245 | ENSXMAP00000021700 | Uncharacterized protein. | Uncharacterized protein. | 0.646 |
LOC102232687 | dkc1 | ENSXMAP00000006245 | ENSXMAP00000023561 | Uncharacterized protein. | Dyskeratosis congenita 1, dyskerin. | 0.644 |
LOC102232687 | gar1 | ENSXMAP00000006245 | ENSXMAP00000002316 | Uncharacterized protein. | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | 0.622 |
LOC102232687 | nhp2 | ENSXMAP00000006245 | ENSXMAP00000007046 | Uncharacterized protein. | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. | 0.641 |
LOC102232687 | nop10 | ENSXMAP00000006245 | ENSXMAP00000027030 | Uncharacterized protein. | NOP10 ribonucleoprotein homolog (yeast). | 0.644 |
LOC102232687 | pot1 | ENSXMAP00000006245 | ENSXMAP00000038374 | Uncharacterized protein. | Telo_bind domain-containing protein. | 0.985 |
LOC102232687 | rpa1 | ENSXMAP00000006245 | ENSXMAP00000036796 | Uncharacterized protein. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.474 |
LOC102232687 | stn1 | ENSXMAP00000006245 | ENSXMAP00000010395 | Uncharacterized protein. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.860 |
LOC102232687 | terf2ip | ENSXMAP00000006245 | ENSXMAP00000017357 | Uncharacterized protein. | BRCT domain-containing protein. | 0.971 |
LOC102232687 | tert | ENSXMAP00000006245 | ENSXMAP00000016432 | Uncharacterized protein. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. | 0.937 |
LOC102232687 | wrap53 | ENSXMAP00000006245 | ENSXMAP00000013617 | Uncharacterized protein. | WD repeat containing, antisense to TP53. | 0.560 |
RPA1 | LOC102232687 | ENSXMAP00000010389 | ENSXMAP00000006245 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | Uncharacterized protein. | 0.474 |
RPA1 | pot1 | ENSXMAP00000010389 | ENSXMAP00000038374 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | Telo_bind domain-containing protein. | 0.550 |
RPA1 | rad50 | ENSXMAP00000010389 | ENSXMAP00000039533 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | RAD50 homolog, double strand break repair protein. | 0.806 |
RPA1 | rad51 | ENSXMAP00000010389 | ENSXMAP00000000592 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.975 |
RPA1 | rpa1 | ENSXMAP00000010389 | ENSXMAP00000036796 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.901 |
RPA1 | stn1 | ENSXMAP00000010389 | ENSXMAP00000010395 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.889 |