(47 nodes) Regulation of mitotic sister chromatid separation network (Xiphophorus maculatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

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Your Input:
	zwilch	Zwilch kinetochore protein. (592 aa)
	anapc7	Anaphase promoting complex subunit 7. (565 aa)
	mad2l1bp	MAD2L1 binding protein. (377 aa)
	bub1b	BUB1 mitotic checkpoint serine/threonine kinase Bb. (430 aa)
	znf207	Zinc finger protein 207, b. (473 aa)
	ttk	Ttk protein kinase. (916 aa)
	riok2	RIO kinase 2 (yeast). (514 aa)
	xrcc3	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (364 aa)
	cdc26	Cell division cycle 26 homolog. (94 aa)
	LOC102221121	Cullin 3; Belongs to the cullin family. (767 aa)
	cdc27	Cell division cycle 27. (803 aa)
	zw10	Zw10 kinetochore protein. (767 aa)
	cdc16	Cell division cycle 16 homolog (S. cerevisiae). (618 aa)
	LOC102217509	Uncharacterized protein. (177 aa)
	mad1l1	Mitotic arrest deficient 1 like 1. (691 aa)
	cdc6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (579 aa)
	LOC102235624	CULLIN_2 domain-containing protein; Belongs to the cullin family. (766 aa)
	LOC102233914	Aurora kinase B; Belongs to the protein kinase superfamily. (366 aa)
	bub3	BUB3 mitotic checkpoint protein. (326 aa)
	atm	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2875 aa)
	anapc1	Anaphase promoting complex subunit 1. (1822 aa)
	lcmt1	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (325 aa)
	kntc1	Kinetochore associated 1. (1735 aa)
	anapc11	APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
	M4AWA9_XIPMA	Translocated promoter region a, nuclear basket protein. (1776 aa)
	ENSXMAP00000021594	CDK5 regulatory subunit associated protein 2. (1124 aa)
	nsmce2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (230 aa)
	anapc15	Anaphase promoting complex subunit 15. (122 aa)
	mad2l1	MAD2 mitotic arrest deficient-like 1 (yeast). (202 aa)
	LOC102217701	Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (580 aa)
	haspin	Si:dkeyp-26a9.2. (1191 aa)
	ENSXMAP00000028709	Uncharacterized protein. (78 aa)
	LOC111611385	Uncharacterized protein. (612 aa)
	rb1	Retinoblastoma susceptibility protein. (912 aa)
	cdc23	CDC23 (cell division cycle 23, yeast, homolog). (575 aa)
	ube2c	Ubiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (174 aa)
	anapc2	Anaphase promoting complex subunit 2; Belongs to the cullin family. (809 aa)
	gen1	Uncharacterized protein. (897 aa)
	anapc4	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (802 aa)
	klhl22	Kelch-like family member 22. (632 aa)
	bcl7a	BAF chromatin remodeling complex subunit BCL7A. (223 aa)
	cdt1	Chromatin licensing and DNA replication factor 1. (761 aa)
	fbxo5	F-box protein 5. (409 aa)
	ndc80	NDC80 kinetochore complex component. (645 aa)
	anapc5	Anaphase promoting complex subunit 5. (773 aa)
	Bub1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (210 aa)
	tpr	Translocated promoter region b, nuclear basket protein. (2281 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bub1	LOC102217509	ENSXMAP00000040519	ENSXMAP00000013721	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.758
Bub1	LOC102233914	ENSXMAP00000040519	ENSXMAP00000016324	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Aurora kinase B; Belongs to the protein kinase superfamily.	0.724
Bub1	LOC111611385	ENSXMAP00000040519	ENSXMAP00000029398	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.949
Bub1	anapc1	ENSXMAP00000040519	ENSXMAP00000017230	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase promoting complex subunit 1.	0.918
Bub1	anapc11	ENSXMAP00000040519	ENSXMAP00000018050	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	APC11 anaphase promoting complex subunit 11 homolog (yeast).	0.816
Bub1	anapc15	ENSXMAP00000040519	ENSXMAP00000022462	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase promoting complex subunit 15.	0.709
Bub1	anapc2	ENSXMAP00000040519	ENSXMAP00000031445	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase promoting complex subunit 2; Belongs to the cullin family.	0.904
Bub1	anapc4	ENSXMAP00000040519	ENSXMAP00000032962	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	0.908
Bub1	anapc5	ENSXMAP00000040519	ENSXMAP00000040462	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase promoting complex subunit 5.	0.908
Bub1	anapc7	ENSXMAP00000040519	ENSXMAP00000004246	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase promoting complex subunit 7.	0.784
Bub1	bub1b	ENSXMAP00000040519	ENSXMAP00000006577	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BUB1 mitotic checkpoint serine/threonine kinase Bb.	0.949
Bub1	bub3	ENSXMAP00000040519	ENSXMAP00000016658	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BUB3 mitotic checkpoint protein.	0.995
Bub1	cdc16	ENSXMAP00000040519	ENSXMAP00000013477	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cell division cycle 16 homolog (S. cerevisiae).	0.920
Bub1	cdc23	ENSXMAP00000040519	ENSXMAP00000031108	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	CDC23 (cell division cycle 23, yeast, homolog).	0.922
Bub1	cdc26	ENSXMAP00000040519	ENSXMAP00000007684	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cell division cycle 26 homolog.	0.742
Bub1	cdc27	ENSXMAP00000040519	ENSXMAP00000012797	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cell division cycle 27.	0.930
Bub1	cdc6	ENSXMAP00000040519	ENSXMAP00000014196	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.656
Bub1	fbxo5	ENSXMAP00000040519	ENSXMAP00000039517	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	F-box protein 5.	0.411
Bub1	haspin	ENSXMAP00000040519	ENSXMAP00000027998	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Si:dkeyp-26a9.2.	0.493
Bub1	kntc1	ENSXMAP00000040519	ENSXMAP00000017685	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Kinetochore associated 1.	0.803