(88 nodes) Negative regulation of neuron projection development network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sema6a	Semaphorin 6A; Belongs to the semaphorin family. (1016 aa)
	LOC111610977	Si:ch73-40a2.1. (876 aa)
	M3ZYL6_XIPMA	Sema domain-containing protein; Belongs to the semaphorin family. (514 aa)
	efna1	Ephrin-A1b; Belongs to the ephrin family. (232 aa)
	LOC102233736	Spartin b. (549 aa)
	lpar1	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
	ulk2	Unc-51 like autophagy activating kinase 2. (1041 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	dab2	DAB adaptor protein 2. (758 aa)
	LOC111606237	Disco-interacting protein 2 homolog Cb. (1618 aa)
	sema3e	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Belongs to the semaphorin family. (794 aa)
	LOC102236687	Sema domain-containing protein. (1092 aa)
	sema3d	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; Belongs to the semaphorin family. (804 aa)
	rtn4rl1	Reticulon 4 receptor-like 1b. (449 aa)
	bicdl1	BICD family like cargo adaptor 1. (564 aa)
	stmn2	Stathmin; Belongs to the stathmin family. (179 aa)
	rtn4r	Reticulon 4 receptor. (467 aa)
	LOC102218264	Sema domain-containing protein; Belongs to the semaphorin family. (834 aa)
	ITM2C	Integral membrane protein 2C. (259 aa)
	sema4c	Uncharacterized protein; Belongs to the semaphorin family. (861 aa)
	LOC102217859	Progestin and adipoQ receptor family member IIIb. (315 aa)
	LOC102238203	Disco-interacting protein 2 homolog Bb. (1501 aa)
	LOC102238002	Unc-51 like autophagy activating kinase 1a. (892 aa)
	LOC102219029	TSC complex subunit 1. (977 aa)
	LOC102220201	Sialidase 4. (477 aa)
	sema6d	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like; Belongs to the semaphorin family. (1109 aa)
	LOC102219897	Disco-interacting protein 2 homolog Ba. (1583 aa)
	paqr3	Progestin and adipoQ receptor family member IIIa. (411 aa)
	sema5a	Sema domain-containing protein. (1078 aa)
	dip2c	DMAP-interaction domain-containing protein. (1687 aa)
	LOC102216533	Reticulon 4 receptor-like 1a. (454 aa)
	ryk	Receptor like tyrosine kinase. (629 aa)
	LOC102233534	Disco-interacting protein 2 homolog C-like. (1618 aa)
	wnt3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	SEMA4F	Ssemaphorin 4F; Belongs to the semaphorin family. (843 aa)
	ENSXMAP00000034571	Sema domain-containing protein; Belongs to the semaphorin family. (688 aa)
	ENSXMAP00000035024	Uncharacterized protein. (322 aa)
	LOC102221546	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa; Belongs to the semaphorin family. (820 aa)
	LOC102234533	Sema domain-containing protein; Belongs to the semaphorin family. (1174 aa)
	sema3b	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family. (809 aa)
	LOC102222696	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb; Belongs to the semaphorin family. (814 aa)
	LOC102231783	Stathmin; Belongs to the stathmin family. (180 aa)
	LOC102235488	Ubiquitin protein ligase E3A. (823 aa)
	sema3a	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab; Belongs to the semaphorin family. (804 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (908 aa)
	LOC102226621	Si:ch211-129c21.1; Belongs to the semaphorin family. (798 aa)
	LOC102236308	Uncharacterized protein. (1084 aa)
	sema3c	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Belongs to the semaphorin family. (748 aa)
	LOC102223459	Interferon-related developmental regulator 2. (455 aa)
	LOC102236619	Sema domain-containing protein; Belongs to the semaphorin family. (820 aa)
	ifrd1	Interferon-related developmental regulator 1. (428 aa)
	LOC102233681	Si:dkey-49n23.1; Belongs to the semaphorin family. (791 aa)
	sema6b	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb; Belongs to the semaphorin family. (870 aa)
	LOC102231237	Si:ch211-113g11.6; Belongs to the semaphorin family. (641 aa)
	LOC102226889	Ephrin-A1a; Belongs to the ephrin family. (222 aa)
	LOC102232293	Apolipoprotein Ea. (251 aa)
	dip2a	Disco-interacting protein 2 homolog A. (1601 aa)
	sema4g	Uncharacterized protein; Belongs to the semaphorin family. (844 aa)
	LOC102217038	FAT atypical cadherin 3b. (4363 aa)
	M4ATY9_XIPMA	dNK domain-containing protein. (187 aa)
	minar1	UPF0258 domain-containing protein. (803 aa)
	LOC102216911	Apolipoprotein Eb. (265 aa)
	cdk5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	LOC102237426	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E; Belongs to the semaphorin family. (1086 aa)
	LOC102220143	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba; Belongs to the semaphorin family. (899 aa)
	sema3g	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl; Belongs to the semaphorin family. (784 aa)
	LOC102237592	Semaphorin 4e; Belongs to the semaphorin family. (834 aa)
	LOC102224004	Sema domain-containing protein; Belongs to the semaphorin family. (837 aa)
	UBE3A	Ubiquitin protein ligase E3A. (1025 aa)
	LOC111612253	Sema domain-containing protein; Belongs to the semaphorin family. (683 aa)
	fat3	FAT atypical cadherin 3a. (4665 aa)
	LOC102234982	Dickkopf WNT signaling pathway inhibitor 1a. (279 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2328 aa)
	LOC102220119	Uncharacterized protein; Belongs to the semaphorin family. (788 aa)
	snapin	SNAP associated protein. (129 aa)
	kremen1	Kringle containing transmembrane protein 1. (476 aa)
	epha4	Eph receptor A4, like. (1026 aa)
	LOC102225447	Uncharacterized protein; Belongs to the semaphorin family. (880 aa)
	RAB29	RAB29, member RAS oncogene family. (206 aa)
	sema5b	Sema domain-containing protein. (1107 aa)
	rufy3	RUN and FYVE domain containing 3. (659 aa)
	LOC102237756	TSC complex subunit 1b. (1243 aa)
	ENSXMAP00000025806	Sema domain-containing protein; Belongs to the semaphorin family. (746 aa)
	LOC102227535	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Aa; Belongs to the semaphorin family. (856 aa)
	sema7a	Semaphorin 7A; Belongs to the semaphorin family. (652 aa)
	LOC102221014	Integral membrane protein 2Cb. (352 aa)
	ulk1	Unc-51 like autophagy activating kinase 1. (1064 aa)
	bag5	BCL2 associated athanogene 5. (495 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102217038	fat3	ENSXMAP00000017791	ENSXMAP00000021733	FAT atypical cadherin 3b.	FAT atypical cadherin 3a.	0.501
LOC102219029	LOC102237756	ENSXMAP00000000496	ENSXMAP00000025664	TSC complex subunit 1.	TSC complex subunit 1b.	0.905
LOC102220143	cdk5	ENSXMAP00000019340	ENSXMAP00000018867	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba; Belongs to the semaphorin family.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.443
LOC102225447	cdk5	ENSXMAP00000024931	ENSXMAP00000018867	Uncharacterized protein; Belongs to the semaphorin family.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.443
LOC102226889	LOC102236308	ENSXMAP00000014823	ENSXMAP00000037887	Ephrin-A1a; Belongs to the ephrin family.	Uncharacterized protein.	0.562
LOC102226889	LOC111610977	ENSXMAP00000014823	ENSXMAP00000008135	Ephrin-A1a; Belongs to the ephrin family.	Si:ch73-40a2.1.	0.562
LOC102226889	epha4	ENSXMAP00000014823	ENSXMAP00000008368	Ephrin-A1a; Belongs to the ephrin family.	Eph receptor A4, like.	0.562
LOC102227535	cdk5	ENSXMAP00000027719	ENSXMAP00000018867	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Aa; Belongs to the semaphorin family.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.563
LOC102234533	cdk5	ENSXMAP00000039777	ENSXMAP00000018867	Sema domain-containing protein; Belongs to the semaphorin family.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.443
LOC102234982	kremen1	ENSXMAP00000022374	ENSXMAP00000024004	Dickkopf WNT signaling pathway inhibitor 1a.	Kringle containing transmembrane protein 1.	0.960
LOC102234982	wnt3	ENSXMAP00000022374	ENSXMAP00000034113	Dickkopf WNT signaling pathway inhibitor 1a.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.439
LOC102234982	wnt3a	ENSXMAP00000022374	ENSXMAP00000005800	Dickkopf WNT signaling pathway inhibitor 1a.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.454
LOC102235488	UBE3A	ENSXMAP00000036228	ENSXMAP00000021050	Ubiquitin protein ligase E3A.	Ubiquitin protein ligase E3A.	0.901
LOC102236308	LOC102226889	ENSXMAP00000037887	ENSXMAP00000014823	Uncharacterized protein.	Ephrin-A1a; Belongs to the ephrin family.	0.562
LOC102236308	efna1	ENSXMAP00000037887	ENSXMAP00000007291	Uncharacterized protein.	Ephrin-A1b; Belongs to the ephrin family.	0.564
LOC102236687	cdk5	ENSXMAP00000004312	ENSXMAP00000018867	Sema domain-containing protein.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.443
LOC102237426	cdk5	ENSXMAP00000019200	ENSXMAP00000018867	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E; Belongs to the semaphorin family.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.443
LOC102237756	LOC102219029	ENSXMAP00000025664	ENSXMAP00000000496	TSC complex subunit 1b.	TSC complex subunit 1.	0.905
LOC102238002	ulk1	ENSXMAP00000001950	ENSXMAP00000029387	Unc-51 like autophagy activating kinase 1a.	Unc-51 like autophagy activating kinase 1.	0.903
LOC102238002	ulk2	ENSXMAP00000001950	ENSXMAP00000005812	Unc-51 like autophagy activating kinase 1a.	Unc-51 like autophagy activating kinase 2.	0.908