(71 nodes) Metencephalon development network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102218757	Uncharacterized protein. (286 aa)
	whrn	Whirlin a. (476 aa)
	LOC102222617	LIM homeobox 1b. (407 aa)
	M3ZFC9_XIPMA	Uncharacterized protein. (629 aa)
	LOC102231096	RNA binding motif protein 7. (262 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (248 aa)
	crk	CRK proto-oncogene, adaptor protein. (306 aa)
	srrm4	Serine/arginine repetitive matrix 4. (627 aa)
	LOC102227017	Coenzyme Q8B. (631 aa)
	abl2	Tyrosine-protein kinase. (1187 aa)
	LOC102223376	Si:ch73-21k16.5; Belongs to the GPAT/DAPAT family. (678 aa)
	LOC102232149	Homeobox protein engrailed-like. (296 aa)
	lhx1	LIM homeobox 1a. (407 aa)
	NCSTN	Nicastrin. (701 aa)
	hspa5	Heat shock protein 5; Belongs to the heat shock protein 70 family. (652 aa)
	kif14	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1085 aa)
	LOC102223068	Uncharacterized protein. (254 aa)
	gnpat	Glyceronephosphate O-acyltransferase; Belongs to the GPAT/DAPAT family. (675 aa)
	rpgrip1l	RPGRIP1 like. (1268 aa)
	M3ZXZ2_XIPMA	Bmi1 polycomb ring finger oncogene 1a. (345 aa)
	KNDC1	Kinase non-catalytic C-lobe domain containing 1. (1808 aa)
	LOC102231594	Sorting nexin 14. (1031 aa)
	SNX14	Sorting nexin 14. (927 aa)
	serpine2	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (442 aa)
	LOC102220874	Homeobox domain-containing protein. (306 aa)
	bmp2	Bone morphogenetic protein 2b. (416 aa)
	LOC102221627	Ubiquinol-cytochrome c reductase, complex III subunit VII. (82 aa)
	klhl5	Kelch-like family member 5. (786 aa)
	LOC102221136	Kelch-like family member 4. (728 aa)
	clp1	Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (441 aa)
	LOC102222655	Cyclin-dependent kinase 5 activator. (334 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (811 aa)
	sez6l2	Seizure related 6 homolog (mouse)-like 2. (891 aa)
	ttc21b	Tetratricopeptide repeat domain 21B. (1291 aa)
	cep290	Centrosomal protein 290. (2250 aa)
	wdr73	WD repeat domain 73. (375 aa)
	LOC102220740	Paired box 2b. (391 aa)
	rest	RE1-silencing transcription factor. (850 aa)
	otx2	Orthodenticle homeobox 2b. (290 aa)
	LOC102225335	Uncharacterized protein. (267 aa)
	cdk5r1	Cyclin-dependent kinase 5 activator. (308 aa)
	sez6l	Seizure related 6 homolog (mouse)-like. (933 aa)
	cdk5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	LOC102232546	Cyclin-dependent kinase 5 activator. (323 aa)
	MAFB	MAF bZIP transcription factor B. (398 aa)
	Cdk5r2	Cyclin-dependent kinase 5, regulatory subunit 2b (p39). (296 aa)
	sez6	Seizure related 6 homolog a. (1023 aa)
	abl1	Tyrosine-protein kinase. (1152 aa)
	LOC102227641	Homeobox protein engrailed-like. (284 aa)
	cep55	Centrosomal protein 55 like. (508 aa)
	phox2a	Paired like homeobox 2A. (301 aa)
	agtpbp1	ATP/GTP binding protein 1. (1234 aa)
	LOC102234689	Paired box 2a. (413 aa)
	gbx2	Gastrulation brain homeobox 2. (350 aa)
	pax8	Paired box 8. (505 aa)
	ENSXMAP00000032037	PDZ domain-containing protein. (120 aa)
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (640 aa)
	crkl	V-crk avian sarcoma virus CT10 oncogene homolog-like. (299 aa)
	LOC102237749	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (240 aa)
	LOC102233680	Whirlin b. (978 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
	ENSXMAP00000034786	Uncharacterized protein. (134 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	pax5	Paired box 5. (425 aa)
	naglu	N-acetylglucosaminidase, alpha. (781 aa)
	pdss2	Prenyl (decaprenyl) diphosphate synthase, subunit 2. (510 aa)
	chmp1a	Charged multivesicular body protein 1A. (181 aa)
	Trnp1	Si:ch211-160f23.7. (260 aa)
	LOC102231331	MBD domain-containing protein. (1180 aa)
	ENSXMAP00000038300	Paired domain-containing protein. (163 aa)
	ttll1	Tubulin tyrosine ligase-like family, member 1. (424 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cdk5r2	cdk5	ENSXMAP00000020106	ENSXMAP00000018867	Cyclin-dependent kinase 5, regulatory subunit 2b (p39).	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.885
ENSXMAP00000032037	ttc21b	ENSXMAP00000032037	ENSXMAP00000011723	PDZ domain-containing protein.	Tetratricopeptide repeat domain 21B.	0.470
LOC102218757	abl1	ENSXMAP00000039060	ENSXMAP00000021596	Uncharacterized protein.	Tyrosine-protein kinase.	0.963
LOC102218757	abl2	ENSXMAP00000039060	ENSXMAP00000003215	Uncharacterized protein.	Tyrosine-protein kinase.	0.963
LOC102218757	crk	ENSXMAP00000039060	ENSXMAP00000002446	Uncharacterized protein.	CRK proto-oncogene, adaptor protein.	0.901
LOC102218757	crkl	ENSXMAP00000039060	ENSXMAP00000032163	Uncharacterized protein.	V-crk avian sarcoma virus CT10 oncogene homolog-like.	0.910
LOC102222655	cdk5	ENSXMAP00000010832	ENSXMAP00000018867	Cyclin-dependent kinase 5 activator.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.885
LOC102223068	cdk5	ENSXMAP00000006169	ENSXMAP00000018867	Uncharacterized protein.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.885
LOC102223376	gnpat	ENSXMAP00000004665	ENSXMAP00000006388	Si:ch73-21k16.5; Belongs to the GPAT/DAPAT family.	Glyceronephosphate O-acyltransferase; Belongs to the GPAT/DAPAT family.	0.903
LOC102225335	smo	ENSXMAP00000016756	ENSXMAP00000011040	Uncharacterized protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.565
LOC102227017	pdss2	ENSXMAP00000002685	ENSXMAP00000035868	Coenzyme Q8B.	Prenyl (decaprenyl) diphosphate synthase, subunit 2.	0.565
LOC102231331	rest	ENSXMAP00000037486	ENSXMAP00000015167	MBD domain-containing protein.	RE1-silencing transcription factor.	0.459
LOC102231331	wdr73	ENSXMAP00000037486	ENSXMAP00000013611	MBD domain-containing protein.	WD repeat domain 73.	0.674
LOC102232546	cdk5	ENSXMAP00000019646	ENSXMAP00000018867	Cyclin-dependent kinase 5 activator.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.885
LOC102233680	rpgrip1l	ENSXMAP00000034169	ENSXMAP00000006764	Whirlin b.	RPGRIP1 like.	0.644
LOC102233680	ttc21b	ENSXMAP00000034169	ENSXMAP00000011723	Whirlin b.	Tetratricopeptide repeat domain 21B.	0.470
LOC102237749	fgf3	ENSXMAP00000033871	ENSXMAP00000001501	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.808
LOC102237749	gbx2	ENSXMAP00000033871	ENSXMAP00000031880	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Gastrulation brain homeobox 2.	0.607
LOC102237749	smo	ENSXMAP00000033871	ENSXMAP00000011040	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.414
LOC102237749	wnt1	ENSXMAP00000033871	ENSXMAP00000035020	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.584