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scn4b scn4b cacng3 cacng3 LOC102225057 LOC102225057 Mtor Mtor LOC102225266 LOC102225266 LOC102216915 LOC102216915 LOC102216590 LOC102216590 cldn19 cldn19 LOC102216648 LOC102216648 nup155 nup155 LOC102220985 LOC102220985 zmpste24 zmpste24 LOC102235612 LOC102235612 kcne4 kcne4 LOC102228764 LOC102228764 LOC102233709 LOC102233709 kcnq1 kcnq1 p2rx3 p2rx3 LOC102237040 LOC102237040 RNF207 RNF207 cldn1 cldn1 LOC102233539 LOC102233539 M4AUN3_XIPMA M4AUN3_XIPMA ENSXMAP00000021447 ENSXMAP00000021447 kcnmb2 kcnmb2 CACNG5 CACNG5 LOC102224234 LOC102224234 cav1 cav1 scn3b scn3b LOC102219201 LOC102219201 p2rx1 p2rx1 LOC102220955 LOC102220955 LOC102216442 LOC102216442 cacng4 cacng4 LOC102216851 LOC102216851 scn2b scn2b ENSXMAP00000034786 ENSXMAP00000034786 GJD2 GJD2 pln pln LOC102226016 LOC102226016 LOC102231241 LOC102231241 LOC102226255 LOC102226255 LOC102227037 LOC102227037
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
scn4bSodium channel, voltage-gated, type IV, beta a. (233 aa)
cacng3Calcium voltage-gated channel auxiliary subunit gamma 3. (317 aa)
LOC102225057Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (403 aa)
MtorSerine/threonine-protein kinase TOR. (1011 aa)
LOC102225266Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (159 aa)
LOC102216915Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1728 aa)
LOC102216590Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (306 aa)
cldn19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
LOC102216648Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (379 aa)
nup155Nucleoporin 155. (1346 aa)
LOC102220985Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (317 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (471 aa)
LOC102235612Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1832 aa)
kcne4Potassium voltage-gated channel, Isk-related family, member 4. (228 aa)
LOC102228764Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (341 aa)
LOC102233709Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1741 aa)
kcnq1Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (691 aa)
p2rx3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (393 aa)
LOC102237040Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
RNF207Ring finger protein 207. (646 aa)
cldn1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (223 aa)
LOC102233539Purinergic receptor P2X, ligand-gated ion channel, 7. (622 aa)
M4AUN3_XIPMATransporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (572 aa)
ENSXMAP00000021447Ion_trans domain-containing protein. (293 aa)
kcnmb2Si:ch211-247n2.1. (233 aa)
CACNG5Calcium channel, voltage-dependent, gamma subunit 5a. (277 aa)
LOC102224234Sodium channel, voltage-gated, type I, beta a. (216 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
scn3bSodium channel, voltage-gated, type III, beta. (219 aa)
LOC102219201Uncharacterized protein; Belongs to the potassium channel family. (742 aa)
p2rx1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (432 aa)
LOC102220955Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (363 aa)
LOC102216442Sodium channel, voltage-gated, type I, beta b. (223 aa)
cacng4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (333 aa)
LOC102216851Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1968 aa)
scn2bSodium channel, voltage-gated, type II, beta. (219 aa)
ENSXMAP00000034786Uncharacterized protein. (134 aa)
GJD2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (304 aa)
plnCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (53 aa)
LOC102226016Junction plakoglobin a. (721 aa)
LOC102231241Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)
LOC102226255Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (328 aa)
LOC102227037Calcium channel, voltage-dependent, gamma subunit 5b. (276 aa)
Your Current Organism:
Xiphophorus maculatus
NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish
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