STRINGSTRING
tp53bp1 tp53bp1 ENSXMAP00000039893 ENSXMAP00000039893 rad50 rad50 ACTR3 ACTR3 sirt6 sirt6 ENSXMAP00000038656 ENSXMAP00000038656 ENSXMAP00000038140 ENSXMAP00000038140 arpc2 arpc2 LOC102230269 LOC102230269 LOC102218487-2 LOC102218487-2 rpa3 rpa3 arpc3 arpc3 parp3 parp3 LOC102227344 LOC102227344 ENSXMAP00000025712 ENSXMAP00000025712 ufl1 ufl1 arpc4 arpc4 rad18 rad18 ENSXMAP00000023261 ENSXMAP00000023261 poll poll M4AYA4_XIPMA M4AYA4_XIPMA rnf8 rnf8 LOC102226689 LOC102226689 smarcad1 smarcad1 LOC102237812 LOC102237812 LOC102216726 LOC102216726 wrap53 wrap53 sirt7 sirt7 hus1 hus1 LOC102234371 LOC102234371 actr2 actr2 nhej1 nhej1 polh polh prpf19 prpf19 tonsl tonsl vcp vcp samhd1 samhd1 LOC102218487 LOC102218487 rbbp8 rbbp8 LOC102224211 LOC102224211 mre11 mre11 paxx paxx parp1 parp1 timeless timeless pnkp pnkp LOC102223120 LOC102223120 LOC102220065 LOC102220065 M3ZIZ6_XIPMA M3ZIZ6_XIPMA WDR70 WDR70 rad51 rad51 rif1 rif1 shld2 shld2 ddb1 ddb1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tp53bp1Tumor protein p53 binding protein, 1. (1252 aa)
ENSXMAP00000039893Si:ch1073-75f15.2. (113 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (427 aa)
sirt6Sirtuin 6. (390 aa)
ENSXMAP00000038656Zgc:165656. (164 aa)
ENSXMAP00000038140Uncharacterized protein. (109 aa)
arpc2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (299 aa)
LOC102230269Uncharacterized protein. (249 aa)
LOC102218487-2Uncharacterized protein. (422 aa)
rpa3Replication protein A3. (122 aa)
arpc3Actin related protein 2/3 complex, subunit 3. (203 aa)
parp3Poly [ADP-ribose] polymerase. (539 aa)
LOC102227344SET domain and mariner transposase fusion gene. (283 aa)
ENSXMAP00000025712BRCT domain-containing protein. (149 aa)
ufl1UFM1-specific ligase 1. (792 aa)
arpc4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (180 aa)
rad18RAD18 E3 ubiquitin protein ligase. (497 aa)
ENSXMAP00000023261Uncharacterized protein; Belongs to the actin family. (206 aa)
pollPolymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (599 aa)
M4AYA4_XIPMAANK_REP_REGION domain-containing protein. (378 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (473 aa)
LOC102226689X-ray repair complementing defective repair in Chinese hamster cells 4. (338 aa)
smarcad1Uncharacterized protein. (1090 aa)
LOC102237812Uncharacterized protein. (224 aa)
LOC102216726Zgc:101810; Belongs to the actin family. (394 aa)
wrap53WD repeat containing, antisense to TP53. (552 aa)
sirt7Sirtuin 7. (408 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (271 aa)
LOC102234371Zgc:136908; Belongs to the AAA ATPase family. (810 aa)
actr2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
nhej1Nonhomologous end-joining factor 1. (305 aa)
polhPolymerase (DNA directed), eta. (720 aa)
prpf19Pre-mRNA processing factor 19. (505 aa)
tonslTonsoku-like, DNA repair protein. (1429 aa)
vcpValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
samhd1SAM domain and HD domain 1. (627 aa)
LOC102218487HD domain-containing protein. (473 aa)
rbbp8Uncharacterized protein. (638 aa)
LOC102224211Uncharacterized protein; Belongs to the actin family. (424 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (743 aa)
paxxPAXX non-homologous end joining factor. (198 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
timelessTimeless circadian clock. (1260 aa)
pnkpPolynucleotide kinase 3'-phosphatase. (590 aa)
LOC102223120Uncharacterized protein. (1279 aa)
LOC102220065Structural maintenance of chromosomes flexible hinge domain containing 1. (1718 aa)
M3ZIZ6_XIPMAStructural maintenance of chromosomes flexible hinge domain containing 1. (1312 aa)
WDR70WD repeat domain 70. (649 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
rif1Replication timing regulatory factor 1. (2191 aa)
shld2Si:ch211-134m17.9. (638 aa)
ddb1Damage-specific DNA binding protein 1. (1081 aa)
Your Current Organism:
Xiphophorus maculatus
NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish
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