(80 nodes) Melanosome network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102224939	RAB5B, member RAS oncogene family. (216 aa)
	LOC102226183	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1685 aa)
	LOC102230820	RAB38c, member of RAS oncogene family. (260 aa)
	LOC102219021	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family. (257 aa)
	LOC102226519	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1677 aa)
	LOC102225357	Synaptotagmin-like 2b. (1622 aa)
	gsn	Gelsolin a. (740 aa)
	tmem33	Transmembrane protein 33. (248 aa)
	sytl1	Synaptotagmin-like 1. (532 aa)
	hps4	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. (611 aa)
	rab32	RAB32a, member RAS oncogene family. (213 aa)
	pdcd6ip	Programmed cell death 6 interacting protein. (765 aa)
	abcb6	ATP-binding cassette, sub-family B (MDR/TAP), member 6a. (852 aa)
	LOC102232710	Uncharacterized protein. (218 aa)
	LOC102223560	Premelanosome protein a. (769 aa)
	dtnbp1	Dystrobrevin binding protein 1b. (227 aa)
	LOC102222087	Cathepsin Bb; Belongs to the peptidase C1 family. (330 aa)
	rab35	RAB35, member RAS oncogene family b. (184 aa)
	gpr143	G protein-coupled receptor 143. (414 aa)
	LOC102223038	SEC22 homolog B, vesicle trafficking protein a; Belongs to the synaptobrevin family. (215 aa)
	dct	Dopachrome tautomerase. (515 aa)
	LOC102223583	Solute carrier family 3 member 2b. (566 aa)
	tyrp1	Tyrosinase related protein 1. (525 aa)
	M3ZSI7_XIPMA	Uncharacterized protein. (74 aa)
	NCSTN	Nicastrin. (701 aa)
	hspa5	Heat shock protein 5; Belongs to the heat shock protein 70 family. (652 aa)
	LOC102225510	Calumenin b. (315 aa)
	LOC102216463	Solute carrier family 1 member 4. (547 aa)
	M4A121_XIPMA	Uncharacterized protein. (373 aa)
	LOC102218115	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2. (733 aa)
	LOC102218377	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1. (724 aa)
	LOC102230289	Si:dkey-61p9.11. (1902 aa)
	slc3a2	Uncharacterized protein. (492 aa)
	LOC102222337	Zgc:91968. (235 aa)
	cnp	Uncharacterized protein. (697 aa)
	ankrd27	Ankyrin repeat domain 27 (VPS9 domain). (1035 aa)
	anxa6	Annexin. (666 aa)
	tyr	Tyrosinase. (540 aa)
	LOC102219238	Tyrosinase-related protein 1b. (533 aa)
	ctns	Cystinosin, lysosomal cystine transporter. (386 aa)
	pdia3	Protein disulfide-isomerase. (495 aa)
	LOC102228404	Uncharacterized protein. (314 aa)
	cltcl1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1616 aa)
	fasn	Coiled-coil domain containing 57. (2508 aa)
	LOC102216620	Uncharacterized protein. (338 aa)
	capg	Capping protein (actin filament), gelsolin-like b. (344 aa)
	LOC102223000	Folate gamma-glutamyl hydrolase. (321 aa)
	hsp90b1	Heat shock protein 90, beta (grp94), member 1. (796 aa)
	slc24a5	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (513 aa)
	LOC102230474	RAB38b, member of RAS oncogene family. (218 aa)
	TYR	Tyrosinase. (541 aa)
	pdia6	Protein disulfide isomerase family A, member 6; Belongs to the protein disulfide isomerase family. (440 aa)
	mfsd12	Major facilitator superfamily domain containing 12a. (479 aa)
	pdia4	Protein disulfide-isomerase A4; Belongs to the protein disulfide isomerase family. (641 aa)
	lamp1	Lysosomal associated membrane protein 1a. (418 aa)
	LOC102226401	Cathepsin Ba; Belongs to the peptidase C1 family. (352 aa)
	LOC102219790	RAB7a, member RAS oncogene family. (207 aa)
	LOC102226146	Folate gamma-glutamyl hydrolase. (311 aa)
	LOC102230027	Carrier domain-containing protein. (2069 aa)
	rab5c	RAB5C, member RAS oncogene family. (220 aa)
	LOC102221989	RAB5A, member RAS oncogene family, a. (216 aa)
	ppib	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
	LOC106700207	Si:dkey-202g17.3. (483 aa)
	LOC102228070	Zgc:162171. (227 aa)
	LOC102227572	Folate gamma-glutamyl hydrolase. (319 aa)
	LOC102226755	Si:dkey-16l2.16. (209 aa)
	LOC102231109	Uncharacterized protein. (223 aa)
	LOC102230535	Uncharacterized protein. (207 aa)
	ganab	Glucosidase, alpha; neutral AB; Belongs to the glycosyl hydrolase 31 family. (952 aa)
	LOC102229565	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (215 aa)
	gpnmb	Glycoprotein (transmembrane) nmb. (622 aa)
	LOC106700248	Uncharacterized protein. (222 aa)
	LOC102229808	RAB27B, member RAS oncogene family. (218 aa)
	LOC102233132	RAB5A, member RAS oncogene family, b. (216 aa)
	slc1a5	Amino acid transporter. (530 aa)
	rab27a	RAB27A, member RAS oncogene family. (220 aa)
	ahcy	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (442 aa)
	oca2	Oculocutaneous albinism II. (840 aa)
	RAB38	RAB38, member RAS oncogene family. (238 aa)
	LOC102236163	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102218115	LOC102218377	ENSXMAP00000008332	ENSXMAP00000008338	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.900
LOC102218115	LOC102219021	ENSXMAP00000008332	ENSXMAP00000000534	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.	0.563
LOC102218115	LOC102229808	ENSXMAP00000008332	ENSXMAP00000040588	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	RAB27B, member RAS oncogene family.	0.564
LOC102218115	LOC102236163	ENSXMAP00000008332	ENSXMAP00000040288	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.563
LOC102218115	hspa5	ENSXMAP00000008332	ENSXMAP00000005698	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Heat shock protein 5; Belongs to the heat shock protein 70 family.	0.753
LOC102218115	ppib	ENSXMAP00000008332	ENSXMAP00000029665	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.524
LOC102218377	LOC102218115	ENSXMAP00000008338	ENSXMAP00000008332	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	0.900
LOC102218377	LOC102219021	ENSXMAP00000008338	ENSXMAP00000000534	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.	0.563
LOC102218377	LOC102236163	ENSXMAP00000008338	ENSXMAP00000040288	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.563
LOC102218377	hspa5	ENSXMAP00000008338	ENSXMAP00000005698	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Heat shock protein 5; Belongs to the heat shock protein 70 family.	0.753
LOC102218377	ppib	ENSXMAP00000008338	ENSXMAP00000029665	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.524
LOC102219021	LOC102218115	ENSXMAP00000000534	ENSXMAP00000008332	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	0.563
LOC102219021	LOC102218377	ENSXMAP00000000534	ENSXMAP00000008338	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.563
LOC102219021	LOC102226755	ENSXMAP00000000534	ENSXMAP00000032280	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.	Si:dkey-16l2.16.	0.453
LOC102219021	LOC102236163	ENSXMAP00000000534	ENSXMAP00000040288	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.900
LOC102219021	rab35	ENSXMAP00000000534	ENSXMAP00000004030	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.	RAB35, member RAS oncogene family b.	0.453
LOC102219238	LOC102223560	ENSXMAP00000012089	ENSXMAP00000003333	Tyrosinase-related protein 1b.	Premelanosome protein a.	0.582
LOC102219238	dct	ENSXMAP00000012089	ENSXMAP00000004598	Tyrosinase-related protein 1b.	Dopachrome tautomerase.	0.904
LOC102219238	gpnmb	ENSXMAP00000012089	ENSXMAP00000035944	Tyrosinase-related protein 1b.	Glycoprotein (transmembrane) nmb.	0.412
LOC102219238	gpr143	ENSXMAP00000012089	ENSXMAP00000004346	Tyrosinase-related protein 1b.	G protein-coupled receptor 143.	0.409