(34 nodes) DNA-templated DNA replication maintenance of fidelity network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fbh1	F-box DNA helicase 1. (1056 aa)
	SMARCAL1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (930 aa)
	Cenpx	Uncharacterized protein. (63 aa)
	LOC102233674	Uncharacterized protein. (1901 aa)
	pold1	DNA polymerase. (1105 aa)
	eme1	Essential meiotic structure-specific endonuclease 1. (536 aa)
	EME2	ERCC4 domain-containing protein. (438 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2443 aa)
	Atrx	ATRX chromatin remodeler. (1195 aa)
	zranb3	Zinc finger, RAN-binding domain containing 3. (1095 aa)
	tonsl	Tonsoku-like, DNA repair protein. (1429 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2281 aa)
	fancm	Uncharacterized protein. (1911 aa)
	samhd1	SAM domain and HD domain 1. (627 aa)
	LOC102218487	HD domain-containing protein. (473 aa)
	brca2	BRCA2 DNA repair associated. (3052 aa)
	primpol	Primase and polymerase (DNA-directed). (525 aa)
	DONSON	Downstream neighbor of SON. (584 aa)
	mms22l	MMS22-like, DNA repair protein. (1227 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (743 aa)
	exd2	Exonuclease 3'-5' domain containing 2. (639 aa)
	timeless	Timeless circadian clock. (1260 aa)
	thoc1	THO complex 1. (654 aa)
	traip	TRAF-interacting protein. (448 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
	ENSXMAP00000039466	Uncharacterized protein. (100 aa)
	etaa1	Uncharacterized protein. (524 aa)
	tipin	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (290 aa)
	dna2	Uncharacterized protein. (1324 aa)
	LOC102218487-2	Uncharacterized protein. (422 aa)
	gen1	Uncharacterized protein. (897 aa)
	blm	BLM RecQ like helicase. (1398 aa)
	LOC102227344	SET domain and mariner transposase fusion gene. (283 aa)
	ZNF830	Zinc finger protein 830. (335 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atrx	blm	ENSXMAP00000009158	ENSXMAP00000027372	ATRX chromatin remodeler.	BLM RecQ like helicase.	0.427
Atrx	brca2	ENSXMAP00000009158	ENSXMAP00000006983	ATRX chromatin remodeler.	BRCA2 DNA repair associated.	0.416
Atrx	fancm	ENSXMAP00000009158	ENSXMAP00000007734	ATRX chromatin remodeler.	Uncharacterized protein.	0.750
Atrx	mre11	ENSXMAP00000009158	ENSXMAP00000004014	ATRX chromatin remodeler.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.433
Atrx	rad51	ENSXMAP00000009158	ENSXMAP00000000592	ATRX chromatin remodeler.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.815
Cenpx	fancm	ENSXMAP00000012359	ENSXMAP00000007734	Uncharacterized protein.	Uncharacterized protein.	0.977
DONSON	fancm	ENSXMAP00000004418	ENSXMAP00000007734	Downstream neighbor of SON.	Uncharacterized protein.	0.582
DONSON	primpol	ENSXMAP00000004418	ENSXMAP00000005622	Downstream neighbor of SON.	Primase and polymerase (DNA-directed).	0.457
EME2	blm	ENSXMAP00000009907	ENSXMAP00000027372	ERCC4 domain-containing protein.	BLM RecQ like helicase.	0.448
EME2	brca2	ENSXMAP00000009907	ENSXMAP00000006983	ERCC4 domain-containing protein.	BRCA2 DNA repair associated.	0.405
EME2	dna2	ENSXMAP00000009907	ENSXMAP00000034706	ERCC4 domain-containing protein.	Uncharacterized protein.	0.600
EME2	eme1	ENSXMAP00000009907	ENSXMAP00000011572	ERCC4 domain-containing protein.	Essential meiotic structure-specific endonuclease 1.	0.967
EME2	fancm	ENSXMAP00000009907	ENSXMAP00000007734	ERCC4 domain-containing protein.	Uncharacterized protein.	0.644
EME2	gen1	ENSXMAP00000009907	ENSXMAP00000031938	ERCC4 domain-containing protein.	Uncharacterized protein.	0.536
EME2	mre11	ENSXMAP00000009907	ENSXMAP00000004014	ERCC4 domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.476
EME2	pold1	ENSXMAP00000009907	ENSXMAP00000011793	ERCC4 domain-containing protein.	DNA polymerase.	0.567
EME2	rad51	ENSXMAP00000009907	ENSXMAP00000000592	ERCC4 domain-containing protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.464
LOC102233674	blm	ENSXMAP00000012074	ENSXMAP00000027372	Uncharacterized protein.	BLM RecQ like helicase.	0.427
LOC102233674	brca2	ENSXMAP00000012074	ENSXMAP00000006983	Uncharacterized protein.	BRCA2 DNA repair associated.	0.416
LOC102233674	fancm	ENSXMAP00000012074	ENSXMAP00000007734	Uncharacterized protein.	Uncharacterized protein.	0.750