(48 nodes) Regulation of mitochondrial membrane potential network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pink1	PTEN induced kinase 1. (575 aa)
	HSH2D	Hematopoietic SH2 domain containing. (362 aa)
	fam102b	Family with sequence similarity 102 member Bb. (439 aa)
	LOC102222476	PRELI domain containing 1b. (207 aa)
	LOC102216602	Beta-carotene 15, 15-dioxygenase 2, like. (554 aa)
	LOC102238210	Zgc:153993. (189 aa)
	LOC102228842	PRA1 family protein. (190 aa)
	LOC102233266	PRA1 family protein. (160 aa)
	LOC102216537	Heme-binding protein soul5. (218 aa)
	LOC102237875	Family with sequence similarity 102 member Aa. (385 aa)
	gclm	Glutamate-cysteine ligase, modifier subunit. (276 aa)
	LOC102226090	Family with sequence similarity 102 member Ba. (366 aa)
	LOC102235759	Heme binding protein 2. (192 aa)
	LOC102233736	Spartin b. (549 aa)
	M3ZUL3_XIPMA	Beta-carotene oxygenase 2b. (560 aa)
	M3ZTX9_XIPMA	Uncharacterized protein. (191 aa)
	LOC102225549	PRELI/MSF1 domain-containing protein. (210 aa)
	stoml2	Stomatin (EPB72)-like 2. (375 aa)
	rnf122	Ring finger protein 122. (159 aa)
	slc4a11	Solute carrier family 4 member 11. (855 aa)
	ENSXMAP00000032446	Ubiquitin-like domain-containing protein. (138 aa)
	ENSXMAP00000032447	Olfactomedin-like domain-containing protein. (471 aa)
	bcl2	BCL2 apoptosis regulator b. (229 aa)
	SLC4A11	Solute carrier family 4 member 11. (860 aa)
	dcn	Decorin; May affect the rate of fibrils formation. (360 aa)
	ENSXMAP00000038106	Parkin RBR E3 ubiquitin protein ligase. (257 aa)
	prdx3	Peroxiredoxin 3. (273 aa)
	pid1	Phosphotyrosine interaction domain containing 1. (225 aa)
	BAX	BCL2 associated X, apoptosis regulator. (190 aa)
	LOC106700271	Uncharacterized protein. (207 aa)
	prelid1	PRELI domain containing 1a. (210 aa)
	gclc	Glutamate-cysteine ligase, catalytic subunit. (630 aa)
	NDUFS1	NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family. (744 aa)
	vamp4	Myocilin. (625 aa)
	LOC102227947	Beta-carotene oxygenase 2a. (550 aa)
	mul1	Mitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
	arl6ip5	PRA1 family protein. (192 aa)
	LOC102233539	Purinergic receptor P2X, ligand-gated ion channel, 7. (622 aa)
	tusc2	Tumor suppressor 2, mitochondrial calcium regulator a. (109 aa)
	LOC102226579	Tumor suppressor 2, mitochondrial calcium regulator b. (111 aa)
	MTLN	Mitoregulin. (56 aa)
	NDUFS1-2	NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family. (750 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2328 aa)
	stox1	Storkhead box 1. (1089 aa)
	mllt11	MLLT11 transcription factor 7 cofactor. (86 aa)
	LOC102225224	Family with sequence similarity 102 member Ab. (374 aa)
	pip5kl1	Phosphatidylinositol-4-phosphate 5-kinase-like 1. (461 aa)
	bad	BCL2 associated agonist of cell death b. (166 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAX	LOC102238210	ENSXMAP00000009256	ENSXMAP00000001536	BCL2 associated X, apoptosis regulator.	Zgc:153993.	0.987
BAX	LOC106700271	ENSXMAP00000009256	ENSXMAP00000009257	BCL2 associated X, apoptosis regulator.	Uncharacterized protein.	0.903
BAX	bad	ENSXMAP00000009256	ENSXMAP00000025380	BCL2 associated X, apoptosis regulator.	BCL2 associated agonist of cell death b.	0.751
BAX	bcl2	ENSXMAP00000009256	ENSXMAP00000034296	BCL2 associated X, apoptosis regulator.	BCL2 apoptosis regulator b.	0.995
ENSXMAP00000032446	lrrk2	ENSXMAP00000032446	ENSXMAP00000022786	Ubiquitin-like domain-containing protein.	Leucine-rich repeat kinase 2.	0.502
ENSXMAP00000032446	mul1	ENSXMAP00000032446	ENSXMAP00000012442	Ubiquitin-like domain-containing protein.	Mitochondrial E3 ubiquitin protein ligase 1b.	0.697
ENSXMAP00000032446	pink1	ENSXMAP00000032446	ENSXMAP00000012403	Ubiquitin-like domain-containing protein.	PTEN induced kinase 1.	0.978
ENSXMAP00000038106	lrrk2	ENSXMAP00000038106	ENSXMAP00000022786	Parkin RBR E3 ubiquitin protein ligase.	Leucine-rich repeat kinase 2.	0.502
ENSXMAP00000038106	pink1	ENSXMAP00000038106	ENSXMAP00000012403	Parkin RBR E3 ubiquitin protein ligase.	PTEN induced kinase 1.	0.973
LOC102238210	BAX	ENSXMAP00000001536	ENSXMAP00000009256	Zgc:153993.	BCL2 associated X, apoptosis regulator.	0.987
LOC102238210	LOC106700271	ENSXMAP00000001536	ENSXMAP00000009257	Zgc:153993.	Uncharacterized protein.	0.978
LOC102238210	bad	ENSXMAP00000001536	ENSXMAP00000025380	Zgc:153993.	BCL2 associated agonist of cell death b.	0.785
LOC102238210	bcl2	ENSXMAP00000001536	ENSXMAP00000034296	Zgc:153993.	BCL2 apoptosis regulator b.	0.983
LOC106700271	BAX	ENSXMAP00000009257	ENSXMAP00000009256	Uncharacterized protein.	BCL2 associated X, apoptosis regulator.	0.903
LOC106700271	LOC102238210	ENSXMAP00000009257	ENSXMAP00000001536	Uncharacterized protein.	Zgc:153993.	0.978
LOC106700271	bad	ENSXMAP00000009257	ENSXMAP00000025380	Uncharacterized protein.	BCL2 associated agonist of cell death b.	0.806
LOC106700271	bcl2	ENSXMAP00000009257	ENSXMAP00000034296	Uncharacterized protein.	BCL2 apoptosis regulator b.	0.979
NDUFS1	NDUFS1-2	ENSXMAP00000010626	ENSXMAP00000021319	NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family.	NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family.	0.900
NDUFS1	prdx3	ENSXMAP00000010626	ENSXMAP00000039429	NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family.	Peroxiredoxin 3.	0.755
NDUFS1-2	NDUFS1	ENSXMAP00000021319	ENSXMAP00000010626	NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family.	NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family.	0.900