(45 nodes) Cardiac muscle cell differentiation network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	M4ARB7_XIPMA	Mesoderm posterior ba. (237 aa)
	LOC102219029	TSC complex subunit 1. (977 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1011 aa)
	tbx1	T-box transcription factor 1. (498 aa)
	LRRC10B	Leucine rich repeat containing 10B. (407 aa)
	LOC102225231	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily. (418 aa)
	LOC102231173	T-box transcription factor 5a. (516 aa)
	opa1	OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1031 aa)
	LOC102218199	Ankyrin repeat and SOCS box containing 2a, tandem duplicate 1. (621 aa)
	LOC102218460	Ankyrin repeat and SOCS box containing 2a, tandem duplicate 1. (722 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (471 aa)
	bmp2	Bone morphogenetic protein 2b. (416 aa)
	tcap	Titin-cap (telethonin). (179 aa)
	nkx2-5	NK2 homeobox 5. (319 aa)
	nox4	FAD-binding FR-type domain-containing protein. (559 aa)
	LOC102237203	Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (506 aa)
	sgcb	Sarcoglycan, beta (dystrophin-associated glycoprotein). (312 aa)
	acadm	Acyl-CoA dehydrogenase medium chain. (422 aa)
	LOC102232783	Von Willebrand factor A domain containing 5B2. (1390 aa)
	neb	Nebulin. (6142 aa)
	M4AXX7_XIPMA	Uncharacterized protein. (279 aa)
	GREM1	Gremlin. (182 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (326 aa)
	SRF	Serum response factor. (597 aa)
	nrap	Nebulin-related anchoring protein. (1796 aa)
	csrp3	Cysteine and glycine-rich protein 3 (cardiac LIM protein). (210 aa)
	LOC111608470	Uncharacterized protein. (1625 aa)
	LOC102217519	MADS-box domain-containing protein. (470 aa)
	LOC102237756	TSC complex subunit 1b. (1243 aa)
	adprhl1	ADP-ribosylhydrolase like 1. (1012 aa)
	mef2c	Myocyte enhancer factor 2cb. (472 aa)
	mef2a	Myocyte enhancer factor 2aa. (535 aa)
	LOC102230127	Uncharacterized protein. (254 aa)
	alpk3	Uncharacterized protein. (1810 aa)
	LOC102237749	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (240 aa)
	map2k4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (436 aa)
	LOC102225181	Lysine (K)-specific demethylase 6B, a. (2105 aa)
	hand2	Heart and neural crest derivatives expressed 2. (246 aa)
	LOC102229912	MADS-box domain-containing protein. (469 aa)
	LOC102237438	Lysine (K)-specific demethylase 6B, b. (1726 aa)
	bmp4	Bone morphogenetic protein 4. (399 aa)
	maml1	Mastermind-like transcriptional coactivator 1. (870 aa)
	sirt6	Sirtuin 6. (390 aa)
	ENSXMAP00000039114	Bone morphogenetic protein 16. (511 aa)
	irx3	Iroquois homeobox 3a. (450 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSXMAP00000039114	GREM1	ENSXMAP00000039114	ENSXMAP00000020256	Bone morphogenetic protein 16.	Gremlin.	0.712
ENSXMAP00000039114	bmp2	ENSXMAP00000039114	ENSXMAP00000008579	Bone morphogenetic protein 16.	Bone morphogenetic protein 2b.	0.904
GREM1	ENSXMAP00000039114	ENSXMAP00000020256	ENSXMAP00000039114	Gremlin.	Bone morphogenetic protein 16.	0.712
GREM1	bmp2	ENSXMAP00000020256	ENSXMAP00000008579	Gremlin.	Bone morphogenetic protein 2b.	0.712
GREM1	bmp4	ENSXMAP00000020256	ENSXMAP00000038253	Gremlin.	Bone morphogenetic protein 4.	0.712
LOC102217519	nkx2-5	ENSXMAP00000024606	ENSXMAP00000010285	MADS-box domain-containing protein.	NK2 homeobox 5.	0.726
LOC102219029	LOC102225181	ENSXMAP00000000496	ENSXMAP00000034817	TSC complex subunit 1.	Lysine (K)-specific demethylase 6B, a.	0.719
LOC102219029	LOC102237438	ENSXMAP00000000496	ENSXMAP00000038030	TSC complex subunit 1.	Lysine (K)-specific demethylase 6B, b.	0.719
LOC102219029	LOC102237756	ENSXMAP00000000496	ENSXMAP00000025664	TSC complex subunit 1.	TSC complex subunit 1b.	0.905
LOC102219029	Mtor	ENSXMAP00000000496	ENSXMAP00000001362	TSC complex subunit 1.	Serine/threonine-protein kinase TOR.	0.892
LOC102225181	LOC102219029	ENSXMAP00000034817	ENSXMAP00000000496	Lysine (K)-specific demethylase 6B, a.	TSC complex subunit 1.	0.719
LOC102225181	LOC102237756	ENSXMAP00000034817	ENSXMAP00000025664	Lysine (K)-specific demethylase 6B, a.	TSC complex subunit 1b.	0.719
LOC102225231	map2k4	ENSXMAP00000005275	ENSXMAP00000034735	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.900
LOC102229912	SRF	ENSXMAP00000035017	ENSXMAP00000021858	MADS-box domain-containing protein.	Serum response factor.	0.903
LOC102229912	irx3	ENSXMAP00000035017	ENSXMAP00000039935	MADS-box domain-containing protein.	Iroquois homeobox 3a.	0.421
LOC102229912	nkx2-5	ENSXMAP00000035017	ENSXMAP00000010285	MADS-box domain-containing protein.	NK2 homeobox 5.	0.542
LOC102230127	nkx2-5	ENSXMAP00000030105	ENSXMAP00000010285	Uncharacterized protein.	NK2 homeobox 5.	0.457
LOC102231173	bmp4	ENSXMAP00000005373	ENSXMAP00000038253	T-box transcription factor 5a.	Bone morphogenetic protein 4.	0.498
LOC102231173	hand2	ENSXMAP00000005373	ENSXMAP00000034923	T-box transcription factor 5a.	Heart and neural crest derivatives expressed 2.	0.658
LOC102231173	mef2c	ENSXMAP00000005373	ENSXMAP00000027879	T-box transcription factor 5a.	Myocyte enhancer factor 2cb.	0.487