STRINGSTRING
bmp4 bmp4 sema3c sema3c LOC102237370 LOC102237370 LOC102218137 LOC102218137 LOC102216881 LOC102216881 fgf1 fgf1 wnt6 wnt6 LOC102230901 LOC102230901 fgf7 fgf7 lrp6 lrp6 LOC102223598 LOC102223598 ctsh ctsh timeless timeless ctsz ctsz il10 il10 ILK ILK LOC102228719 LOC102228719 LOC102235611 LOC102235611 spint1 spint1 bmp2 bmp2 fem1b fem1b ednra ednra LOC102223662 LOC102223662 hhip hhip M4A7A6_XIPMA M4A7A6_XIPMA LOC102219562 LOC102219562 M4ADI1_XIPMA M4ADI1_XIPMA pkd1 pkd1 LOC102228512 LOC102228512 LOC102219383 LOC102219383 mks1 mks1 wt1 wt1 TGFBR2 TGFBR2 LOC102235305 LOC102235305 edn1 edn1 ENSXMAP00000039114 ENSXMAP00000039114 sars1 sars1 greb1 greb1 LOC102231522 LOC102231522 spry1 spry1 LOC102219157 LOC102219157 nrarp nrarp LOC102235604 LOC102235604 LOC102225323 LOC102225323 SRF SRF sfrp2 sfrp2 LOC102221365 LOC102221365 LOC102216658 LOC102216658 tcf21 tcf21 LOC102219505 LOC102219505 LOC102232031 LOC102232031 sox10 sox10 med1 med1 LOC102229158 LOC102229158 nfatc4 nfatc4 btbd7 btbd7 EDNRA EDNRA LOC102231514 LOC102231514 gdnf gdnf lef1 lef1 ctnnbip1 ctnnbip1 SMAD4 SMAD4 ENSXMAP00000031612 ENSXMAP00000031612 gbx2 gbx2 LOC102217141 LOC102217141 ppp3r1 ppp3r1 LOC102232586 LOC102232586 LOC102229912 LOC102229912 ar ar dag1 dag1 lrp5 lrp5 tmed2 tmed2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bmp4Bone morphogenetic protein 4. (399 aa)
sema3cSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Belongs to the semaphorin family. (748 aa)
LOC102237370Colony stimulating factor 1b (macrophage). (271 aa)
LOC102218137Uncharacterized protein. (432 aa)
LOC102216881Transforming growth factor beta; Belongs to the TGF-beta family. (394 aa)
fgf1Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (167 aa)
wnt6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LOC102230901Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (303 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
lrp6Low density lipoprotein receptor-related protein 6. (1610 aa)
LOC102223598Uncharacterized protein. (685 aa)
ctshCathepsin H; Belongs to the peptidase C1 family. (325 aa)
timelessTimeless circadian clock. (1260 aa)
ctszCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
il10Interleukin 10. (181 aa)
ILKIntegrin linked kinase. (452 aa)
LOC102228719Mothers against decapentaplegic homolog. (503 aa)
LOC102235611WT1 transcription factor a. (429 aa)
spint1Serine peptidase inhibitor, Kunitz type 1 a. (484 aa)
bmp2Bone morphogenetic protein 2b. (416 aa)
fem1bFem-1 homolog b (C. elegans). (627 aa)
ednraEndothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (444 aa)
LOC102223662Serine peptidase inhibitor, Kunitz type 1 b. (500 aa)
hhipHedgehog interacting protein. (697 aa)
M4A7A6_XIPMAMusculin (activated B-cell factor-1). (163 aa)
LOC102219562SRY-box transcription factor 9b. (478 aa)
M4ADI1_XIPMASuppressor of cytokine signaling 3a. (251 aa)
pkd1Polycystic kidney disease 1a. (4563 aa)
LOC102228512Transmembrane protein 59-like. (340 aa)
LOC102219383Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (456 aa)
mks1MKS transition zone complex subunit 1. (562 aa)
wt1WT1 transcription factor b. (422 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (539 aa)
LOC102235305Peptidase S72 domain-containing protein. (908 aa)
edn1Endothelin 1. (197 aa)
ENSXMAP00000039114Bone morphogenetic protein 16. (511 aa)
sars1Seryl-tRNA synthetase. (516 aa)
greb1Growth regulating estrogen receptor binding 1. (1993 aa)
LOC102231522Uncharacterized protein. (452 aa)
spry1Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (358 aa)
LOC102219157NK3 homeobox 1. (196 aa)
nrarpNOTCH regulated ankyrin repeat protein a. (112 aa)
LOC102235604Sprouty RTK signaling antagonist 2. (349 aa)
LOC102225323Mothers against decapentaplegic homolog. (563 aa)
SRFSerum response factor. (597 aa)
sfrp2Secreted frizzled-related protein 2. (295 aa)
LOC102221365HMG box domain-containing protein. (502 aa)
LOC102216658Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (2014 aa)
tcf21Transcription factor 21. (175 aa)
LOC102219505SRY-box transcription factor 9a. (495 aa)
LOC102232031Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (300 aa)
sox10SRY-box transcription factor 10. (473 aa)
med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1745 aa)
LOC102229158Uncharacterized protein. (341 aa)
nfatc4Nuclear factor of activated T cells 4. (842 aa)
btbd7BTB (POZ) domain containing 7. (1147 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (475 aa)
LOC102231514Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (598 aa)
gdnfGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (254 aa)
lef1Lymphoid enhancer-binding factor 1. (379 aa)
ctnnbip1Catenin, beta interacting protein 1. (81 aa)
SMAD4Mothers against decapentaplegic homolog. (512 aa)
ENSXMAP00000031612Uncharacterized protein. (494 aa)
gbx2Gastrulation brain homeobox 2. (350 aa)
LOC102217141Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (158 aa)
ppp3r1Protein phosphatase 3 regulatory subunit B, alpha. (170 aa)
LOC102232586Suppressor of cytokine signaling 3. (208 aa)
LOC102229912MADS-box domain-containing protein. (469 aa)
arAndrogen receptor. (754 aa)
dag1Dystroglycan 1. (893 aa)
lrp5Low density lipoprotein receptor-related protein 5. (1649 aa)
tmed2Transmembrane p24 trafficking protein 2. (207 aa)
Your Current Organism:
Xiphophorus maculatus
NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.