(92 nodes) Cytoskeleton-dependent cytokinesis network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102222956	Septin 8a; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (474 aa)
	LOC102218933	Si:ch1073-416j23.1. (625 aa)
	usp8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1079 aa)
	LOC102223559	Sorting nexin. (551 aa)
	LOC102231495	Charged multivesicular body protein 4C. (233 aa)
	rock1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1380 aa)
	pdcd6ip	Programmed cell death 6 interacting protein. (765 aa)
	efhc1	EF-hand domain (C-terminal) containing 1. (551 aa)
	incenp	Uncharacterized protein. (752 aa)
	rab35	RAB35, member RAS oncogene family b. (184 aa)
	LOC102221046	Citron rho-interacting serine/threonine kinase b. (1590 aa)
	LOC102231585	Septin 2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (358 aa)
	LOC102225792	Kinesin family member 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1244 aa)
	nusap1	Nucleolar and spindle associated protein 1. (441 aa)
	efhc2	EF-hand domain (C-terminal) containing 2. (752 aa)
	snx33	Sorting nexin. (562 aa)
	anln	Anillin, actin binding protein. (1138 aa)
	unc119	Unc-119 lipid binding chaperone. (239 aa)
	alkbh4	AlkB homolog 4, lysine demthylase. (277 aa)
	rock2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1377 aa)
	SNX18	Sorting nexin. (567 aa)
	bbs4	Bardet-Biedl syndrome 4. (537 aa)
	LOC102227389	Uncharacterized protein; Belongs to the AAA ATPase family. (435 aa)
	mitd1	MIT, microtubule interacting and transport, domain containing 1. (246 aa)
	racgap1	Rac GTPase activating protein 1. (630 aa)
	septin6	Septin 6; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (429 aa)
	zfyve26	Zinc finger, FYVE domain containing 26. (2560 aa)
	LOC102226877	Zgc:63587; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (348 aa)
	LOC102231216	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family. (212 aa)
	spire2	Spire-type actin nucleation factor 2. (771 aa)
	septin10	Septin 10; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (427 aa)
	LOC102233914	Aurora kinase B; Belongs to the protein kinase superfamily. (366 aa)
	VPS4B	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (437 aa)
	ist1	IST1 factor associated with ESCRT-III. (348 aa)
	LOC102221896	Citron rho-interacting serine/threonine kinase a. (1581 aa)
	LOC102224220	Uncharacterized protein. (629 aa)
	LOC102233905	Septin 7b; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (426 aa)
	LOC102219989	Si:dkey-256h2.1. (662 aa)
	rasa1	RAS p21 protein activator (GTPase activating protein) 1a. (1049 aa)
	TMEM250	Transmembrane protein 250. (139 aa)
	LOC102222833	Septin 8b; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (465 aa)
	ENSXMAP00000020770	Si:dkey-185p13.1. (95 aa)
	LOC102223278	Spire-type actin nucleation factor 1a. (789 aa)
	LOC102219068	Septin 9a; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (631 aa)
	ENSXMAP00000021046	DDE_3 domain-containing protein. (158 aa)
	dctn3	Dynactin 3 (p22). (187 aa)
	LOC102220404	Septin 15; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (433 aa)
	ENSXMAP00000021866	DDE_3 domain-containing protein. (145 aa)
	ect2	Epithelial cell transforming 2. (1109 aa)
	lzts2	Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (696 aa)
	ENSXMAP00000023613	Uncharacterized protein. (333 aa)
	ENSXMAP00000025155	Uncharacterized protein. (331 aa)
	KIF23	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (979 aa)
	LOC102236096	Septin 3; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (417 aa)
	ENSXMAP00000025991	annotation not available (331 aa)
	cep55	Centrosomal protein 55 like. (508 aa)
	ENSXMAP00000028786	annotation not available (331 aa)
	spast	Spastin; Belongs to the AAA ATPase family. (507 aa)
	ENSXMAP00000031216	DDE_3 domain-containing protein. (165 aa)
	ENSXMAP00000031814	Uncharacterized protein. (331 aa)
	ENSXMAP00000032264	Uncharacterized protein. (331 aa)
	LOC102226755	Si:dkey-16l2.16. (209 aa)
	ENSXMAP00000032514	Uncharacterized protein. (331 aa)
	ENSXMAP00000032734	Uncharacterized protein. (331 aa)
	LOC102233855	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (442 aa)
	ENSXMAP00000033187	Uncharacterized protein. (331 aa)
	klhdc8a	Kelch domain containing 8A. (354 aa)
	LOC106699885	Uncharacterized protein. (949 aa)
	ENSXMAP00000035974	annotation not available (331 aa)
	ENSXMAP00000036521	DDE_3 domain-containing protein. (201 aa)
	ENSXMAP00000036808	HTH_Tnp_Tc3_2 domain-containing protein. (260 aa)
	LOC102228866	Septin 12; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (952 aa)
	LOC102233741	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (617 aa)
	snx9	Sorting nexin 9b. (663 aa)
	LOC102226486	EABR domain-containing protein. (465 aa)
	LOC102219904	Spire-type actin nucleation factor 1b. (883 aa)
	LOC102217774	Uncharacterized protein. (237 aa)
	LOC102227231	Si:dkey-30c15.10. (807 aa)
	lzts3	Leucine zipper, putative tumor suppressor family member 3b. (1097 aa)
	ENSXMAP00000038993	Uncharacterized protein. (335 aa)
	ENSXMAP00000039404	HTH_Tnp_Tc3_2 domain-containing protein. (238 aa)
	ENSXMAP00000039864	annotation not available (331 aa)
	vps4a	Vacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family. (475 aa)
	ENSXMAP00000040204	HTH_Tnp_Tc3_2 domain-containing protein. (181 aa)
	ENSXMAP00000040306	Uncharacterized protein. (102 aa)
	LOC102216449	Unc-119 lipid binding chaperone. (250 aa)
	LOC102232974	Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (778 aa)
	klhdc8b	Kelch domain containing 8B. (359 aa)
	ENSXMAP00000040970	Uncharacterized protein. (331 aa)
	LOC102226513	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (947 aa)
	jtb	Jumping translocation breakpoint. (150 aa)
	ENSXMAP00000041622	Uncharacterized protein; Belongs to the protein kinase superfamily. (385 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSXMAP00000020770	LOC102231495	ENSXMAP00000020770	ENSXMAP00000002318	Si:dkey-185p13.1.	Charged multivesicular body protein 4C.	0.801
ENSXMAP00000020770	ist1	ENSXMAP00000020770	ENSXMAP00000018353	Si:dkey-185p13.1.	IST1 factor associated with ESCRT-III.	0.915
ENSXMAP00000020770	pdcd6ip	ENSXMAP00000020770	ENSXMAP00000003027	Si:dkey-185p13.1.	Programmed cell death 6 interacting protein.	0.727
ENSXMAP00000020770	spast	ENSXMAP00000020770	ENSXMAP00000029018	Si:dkey-185p13.1.	Spastin; Belongs to the AAA ATPase family.	0.414
ENSXMAP00000041622	KIF23	ENSXMAP00000041622	ENSXMAP00000025175	Uncharacterized protein; Belongs to the protein kinase superfamily.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.479
ENSXMAP00000041622	LOC102221046	ENSXMAP00000041622	ENSXMAP00000004094	Uncharacterized protein; Belongs to the protein kinase superfamily.	Citron rho-interacting serine/threonine kinase b.	0.697
ENSXMAP00000041622	LOC102221896	ENSXMAP00000041622	ENSXMAP00000018369	Uncharacterized protein; Belongs to the protein kinase superfamily.	Citron rho-interacting serine/threonine kinase a.	0.729
ENSXMAP00000041622	LOC102226513	ENSXMAP00000041622	ENSXMAP00000041020	Uncharacterized protein; Belongs to the protein kinase superfamily.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.479
ENSXMAP00000041622	LOC102227231	ENSXMAP00000041622	ENSXMAP00000038645	Uncharacterized protein; Belongs to the protein kinase superfamily.	Si:dkey-30c15.10.	0.700
ENSXMAP00000041622	anln	ENSXMAP00000041622	ENSXMAP00000007452	Uncharacterized protein; Belongs to the protein kinase superfamily.	Anillin, actin binding protein.	0.700
ENSXMAP00000041622	incenp	ENSXMAP00000041622	ENSXMAP00000003895	Uncharacterized protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.488
KIF23	ENSXMAP00000041622	ENSXMAP00000025175	ENSXMAP00000041622	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.479
KIF23	LOC102218933	ENSXMAP00000025175	ENSXMAP00000000274	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Si:ch1073-416j23.1.	0.943
KIF23	LOC102221046	ENSXMAP00000025175	ENSXMAP00000004094	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Citron rho-interacting serine/threonine kinase b.	0.479
KIF23	LOC102221896	ENSXMAP00000025175	ENSXMAP00000018369	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Citron rho-interacting serine/threonine kinase a.	0.479
KIF23	LOC102224220	ENSXMAP00000025175	ENSXMAP00000018515	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.943
KIF23	LOC102225792	ENSXMAP00000025175	ENSXMAP00000005064	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.874
KIF23	LOC102226486	ENSXMAP00000025175	ENSXMAP00000037678	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	EABR domain-containing protein.	0.426
KIF23	LOC102227231	ENSXMAP00000025175	ENSXMAP00000038645	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Si:dkey-30c15.10.	0.766
KIF23	LOC102233914	ENSXMAP00000025175	ENSXMAP00000016324	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Aurora kinase B; Belongs to the protein kinase superfamily.	0.755