(63 nodes) Meiosis I cell cycle process network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ccnb1ip1	Cyclin B1 interacting protein 1. (264 aa)
	mlh3	MutL homolog 3 (E. coli). (1151 aa)
	LOC111610367	ANK_REP_REGION domain-containing protein. (488 aa)
	LOC111607145	Uncharacterized protein. (362 aa)
	ENSXMAP00000031754	Uncharacterized protein. (244 aa)
	msh4	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (912 aa)
	syce3	Uncharacterized protein. (98 aa)
	hsf2bp	Heat shock transcription factor 2 binding protein. (338 aa)
	rec8	Uncharacterized protein. (541 aa)
	psmc3ip	PSMC3 interacting protein. (220 aa)
	ENSXMAP00000028253	Si:dkey-40g16.5. (135 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (754 aa)
	ankle1	Zgc:85936. (1142 aa)
	slx4	BTB domain-containing protein. (1245 aa)
	ENSXMAP00000025468	Uncharacterized protein. (223 aa)
	ccne2	Cyclin E2; Belongs to the cyclin family. (394 aa)
	terb2	Telomere repeat binding bouquet formation protein 2. (211 aa)
	psmd13	Proteasome 26S subunit, non-ATPase 13. (378 aa)
	tdrd9	Tudor domain containing 9. (1268 aa)
	spo11	SPO11 initiator of meiotic double stranded breaks. (387 aa)
	LOC102224555	Forkhead box J3. (604 aa)
	top2b	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1589 aa)
	atm	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2875 aa)
	LOC102221752	Fork-head domain-containing protein. (601 aa)
	ercc1	Excision repair cross-complementation group 1. (350 aa)
	rmi1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (680 aa)
	trip13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (420 aa)
	LOC102217509	Uncharacterized protein. (177 aa)
	bag6	BCL2 associated athanogene 6. (1212 aa)
	LOC102221997	Testis expressed 11. (807 aa)
	msh5	MutS homolog 5. (787 aa)
	sirt7	Sirtuin 7. (408 aa)
	ndc1	NDC1 transmembrane nucleoporin. (669 aa)
	dmc1	DNA meiotic recombinase 1; Belongs to the RecA family. (274 aa)
	Cenpx	Uncharacterized protein. (63 aa)
	meiob	Methionine sulfoxide reductase B1b. (425 aa)
	eme1	Essential meiotic structure-specific endonuclease 1. (536 aa)
	LOC102236202	Bromodomain, testis-specific. (916 aa)
	rad51d	RAD51 paralog D. (339 aa)
	top2a	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1536 aa)
	LOC102218059	Baculoviral IAP repeat containing 5a. (142 aa)
	C1orf146	Chromosome 1 open reading frame 146. (172 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (617 aa)
	EME2	ERCC4 domain-containing protein. (438 aa)
	M4A3H1_XIPMA	HORMA domain containing 1. (241 aa)
	majin	Membrane anchored junction protein. (241 aa)
	ercc4	Excision repair cross-complementation group 4. (893 aa)
	Meioc	Uncharacterized protein. (219 aa)
	SGO1	Shugoshin_C domain-containing protein. (636 aa)
	rad51c	RAD51 paralog C. (352 aa)
	fancm	Uncharacterized protein. (1911 aa)
	LOC102224556	Uncharacterized protein. (192 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (743 aa)
	M3ZPQ6_XIPMA	Helicase for meiosis 1. (869 aa)
	Terb1	Uncharacterized protein. (337 aa)
	brca2	BRCA2 DNA repair associated. (3052 aa)
	fancd2	FA complementation group D2. (1235 aa)
	espl1	Extra spindle pole bodies like 1, separase. (2165 aa)
	ENSXMAP00000041423	PR domain containing 9. (740 aa)
	bcl2l11	Uncharacterized protein. (250 aa)
	fbxo5	F-box protein 5. (409 aa)
	mnd1	Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (199 aa)
	ENSXMAP00000036829	Uncharacterized protein. (329 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf146	LOC102221997	ENSXMAP00000010783	ENSXMAP00000013251	Chromosome 1 open reading frame 146.	Testis expressed 11.	0.416
C1orf146	M3ZPQ6_XIPMA	ENSXMAP00000010783	ENSXMAP00000004199	Chromosome 1 open reading frame 146.	Helicase for meiosis 1.	0.560
C1orf146	msh4	ENSXMAP00000010783	ENSXMAP00000031743	Chromosome 1 open reading frame 146.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.539
C1orf146	msh5	ENSXMAP00000010783	ENSXMAP00000013099	Chromosome 1 open reading frame 146.	MutS homolog 5.	0.465
Cenpx	ercc1	ENSXMAP00000012359	ENSXMAP00000015840	Uncharacterized protein.	Excision repair cross-complementation group 1.	0.458
Cenpx	ercc4	ENSXMAP00000012359	ENSXMAP00000007941	Uncharacterized protein.	Excision repair cross-complementation group 4.	0.444
Cenpx	fancm	ENSXMAP00000012359	ENSXMAP00000007734	Uncharacterized protein.	Uncharacterized protein.	0.977
EME2	ENSXMAP00000025468	ENSXMAP00000009907	ENSXMAP00000025468	ERCC4 domain-containing protein.	Uncharacterized protein.	0.478
EME2	atm	ENSXMAP00000009907	ENSXMAP00000016978	ERCC4 domain-containing protein.	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.430
EME2	brca2	ENSXMAP00000009907	ENSXMAP00000006983	ERCC4 domain-containing protein.	BRCA2 DNA repair associated.	0.405
EME2	eme1	ENSXMAP00000009907	ENSXMAP00000011572	ERCC4 domain-containing protein.	Essential meiotic structure-specific endonuclease 1.	0.967
EME2	ercc1	ENSXMAP00000009907	ENSXMAP00000015840	ERCC4 domain-containing protein.	Excision repair cross-complementation group 1.	0.444
EME2	ercc4	ENSXMAP00000009907	ENSXMAP00000007941	ERCC4 domain-containing protein.	Excision repair cross-complementation group 4.	0.703
EME2	fancd2	ENSXMAP00000009907	ENSXMAP00000001645	ERCC4 domain-containing protein.	FA complementation group D2.	0.425
EME2	fancm	ENSXMAP00000009907	ENSXMAP00000007734	ERCC4 domain-containing protein.	Uncharacterized protein.	0.644
EME2	mre11	ENSXMAP00000009907	ENSXMAP00000004014	ERCC4 domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.476
EME2	mus81	ENSXMAP00000009907	ENSXMAP00000009908	ERCC4 domain-containing protein.	MUS81 structure-specific endonuclease subunit.	0.981
EME2	rad51c	ENSXMAP00000009907	ENSXMAP00000003353	ERCC4 domain-containing protein.	RAD51 paralog C.	0.448
EME2	rad51d	ENSXMAP00000009907	ENSXMAP00000011507	ERCC4 domain-containing protein.	RAD51 paralog D.	0.431
EME2	rmi1	ENSXMAP00000009907	ENSXMAP00000014997	ERCC4 domain-containing protein.	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae).	0.489