(20 nodes) NAD+ binding network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102237357	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (431 aa)
	LOC102217501	Poly [ADP-ribose] polymerase. (1803 aa)
	sirt1	Sirtuin 1. (694 aa)
	sirt7	Sirtuin 7. (408 aa)
	hadha	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
	LOC102227585	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (304 aa)
	sirt3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (341 aa)
	LOC102219275	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (264 aa)
	cryl1	Crystallin, lambda 1. (317 aa)
	uxs1	UDP-glucuronate decarboxylase 1. (441 aa)
	ENSXMAP00000025020	Uncharacterized protein. (125 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (310 aa)
	LOC102221531	Poly [ADP-ribose] polymerase. (1801 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (413 aa)
	ehhadh	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (718 aa)
	hpgd	15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
	sirt6	Sirtuin 6. (390 aa)
	hadh	Hydroxyacyl-CoA dehydrogenase. (318 aa)
	sirt5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (304 aa)
	LOC102237766	Poly [ADP-ribose] polymerase. (1776 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102227585	LOC102237357	ENSXMAP00000016977	ENSXMAP00000001677	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.561
LOC102227585	sirt2	ENSXMAP00000016977	ENSXMAP00000028175	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.624
LOC102227585	sirt3	ENSXMAP00000016977	ENSXMAP00000018428	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.558
LOC102227585	sirt4	ENSXMAP00000016977	ENSXMAP00000025238	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.500
LOC102227585	sirt6	ENSXMAP00000016977	ENSXMAP00000038854	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Sirtuin 6.	0.636
LOC102227585	sirt7	ENSXMAP00000016977	ENSXMAP00000012987	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Sirtuin 7.	0.631
LOC102237357	LOC102227585	ENSXMAP00000001677	ENSXMAP00000016977	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.561
LOC102237357	sirt1	ENSXMAP00000001677	ENSXMAP00000007769	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Sirtuin 1.	0.659
LOC102237357	sirt4	ENSXMAP00000001677	ENSXMAP00000025238	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.533
LOC102237357	sirt5	ENSXMAP00000001677	ENSXMAP00000040532	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.560
LOC102237357	sirt6	ENSXMAP00000001677	ENSXMAP00000038854	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Sirtuin 6.	0.414
cryl1	ehhadh	ENSXMAP00000023079	ENSXMAP00000036336	Crystallin, lambda 1.	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.550
cryl1	hadha	ENSXMAP00000023079	ENSXMAP00000015742	Crystallin, lambda 1.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family.	0.550
ehhadh	cryl1	ENSXMAP00000036336	ENSXMAP00000023079	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	Crystallin, lambda 1.	0.550
ehhadh	hadh	ENSXMAP00000036336	ENSXMAP00000038883	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	Hydroxyacyl-CoA dehydrogenase.	0.966
ehhadh	hadha	ENSXMAP00000036336	ENSXMAP00000015742	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family.	0.934
hadh	ehhadh	ENSXMAP00000038883	ENSXMAP00000036336	Hydroxyacyl-CoA dehydrogenase.	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.966
hadh	hadha	ENSXMAP00000038883	ENSXMAP00000015742	Hydroxyacyl-CoA dehydrogenase.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family.	0.967
hadha	cryl1	ENSXMAP00000015742	ENSXMAP00000023079	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family.	Crystallin, lambda 1.	0.550
hadha	ehhadh	ENSXMAP00000015742	ENSXMAP00000036336	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family.	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.934