(45 nodes) U2-type precatalytic spliceosome network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	prpf38a	Pre-mRNA processing factor 38A. (309 aa)
	sf3a2	Splicing factor 3a, subunit 2. (293 aa)
	lsm8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa)
	ENSXMAP00000030333	SEC63 domain-containing protein. (134 aa)
	sf3a3	Splicing factor 3a, subunit 3. (502 aa)
	SNIP1-2	Smad nuclear interacting protein 1. (271 aa)
	lsm2	U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (93 aa)
	lsm4	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (188 aa)
	lsm5	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (91 aa)
	txnl4a	Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa)
	prpf31	PRP31 pre-mRNA processing factor 31 homolog (yeast). (505 aa)
	sf3b3	Splicing factor 3b, subunit 3. (1217 aa)
	wbp4	Uncharacterized protein. (424 aa)
	SMU1	SMU1 DNA replication regulator and spliceosomal factor. (540 aa)
	phf5a	PHD finger protein 5A. (88 aa)
	snrpd2	Small nuclear ribonucleoprotein Sm D2. (118 aa)
	snrpd3	Small nuclear ribonucleoprotein Sm D3. (127 aa)
	snrpa1	Small nuclear ribonucleoprotein polypeptide A. (268 aa)
	snrnp200	Small nuclear ribonucleoprotein 200 (U5). (1903 aa)
	prpf4	PRP4 pre-mRNA processing factor 4 homolog (yeast). (463 aa)
	snrpd1	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. (119 aa)
	sf3b4	Splicing factor 3b, subunit 4. (391 aa)
	LOC102232375	SMU1 DNA replication regulator and spliceosomal factor b. (511 aa)
	sf3b1	Splicing factor 3b, subunit 1. (1315 aa)
	rnf113a	Ring finger protein 113A. (322 aa)
	sf3b2	Splicing factor 3b, subunit 2. (860 aa)
	eftud2	Elongation factor Tu GTP binding domain containing 2. (971 aa)
	prpf8	Pre-mRNA processing factor 8. (2341 aa)
	snrpe	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (92 aa)
	lsm3	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
	lsm6	LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (80 aa)
	bud13	BUD13 homolog. (497 aa)
	cwc22	CWC22 spliceosome associated protein homolog. (994 aa)
	dhx16	DEAH (Asp-Glu-Ala-His) box polypeptide 16. (1037 aa)
	SNIP1	Smad nuclear interacting protein 1. (365 aa)
	Snrpf	Small nuclear ribonucleoprotein polypeptide F. (85 aa)
	prpf6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae). (969 aa)
	prpf3	PRP3 pre-mRNA processing factor 3 homolog (yeast). (691 aa)
	mfap1	Microfibril associated protein 1. (441 aa)
	cwc27	CWC27 spliceosome associated cyclophilin. (473 aa)
	sf3b5	Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa)
	lsm7	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (109 aa)
	zmat2	Zinc finger, matrin-type 2. (198 aa)
	sf3a1	Splicing factor 3a, subunit 1. (784 aa)
	ENSXMAP00000022713	Small nuclear ribonucleoprotein-associated protein. (234 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSXMAP00000022713	Snrpf	ENSXMAP00000022713	ENSXMAP00000015470	Small nuclear ribonucleoprotein-associated protein.	Small nuclear ribonucleoprotein polypeptide F.	0.927
ENSXMAP00000022713	eftud2	ENSXMAP00000022713	ENSXMAP00000008530	Small nuclear ribonucleoprotein-associated protein.	Elongation factor Tu GTP binding domain containing 2.	0.533
ENSXMAP00000022713	lsm7	ENSXMAP00000022713	ENSXMAP00000020542	Small nuclear ribonucleoprotein-associated protein.	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated.	0.417
ENSXMAP00000022713	phf5a	ENSXMAP00000022713	ENSXMAP00000000678	Small nuclear ribonucleoprotein-associated protein.	PHD finger protein 5A.	0.501
ENSXMAP00000022713	prpf3	ENSXMAP00000022713	ENSXMAP00000016388	Small nuclear ribonucleoprotein-associated protein.	PRP3 pre-mRNA processing factor 3 homolog (yeast).	0.424
ENSXMAP00000022713	prpf31	ENSXMAP00000022713	ENSXMAP00000036565	Small nuclear ribonucleoprotein-associated protein.	PRP31 pre-mRNA processing factor 31 homolog (yeast).	0.418
ENSXMAP00000022713	prpf4	ENSXMAP00000022713	ENSXMAP00000002749	Small nuclear ribonucleoprotein-associated protein.	PRP4 pre-mRNA processing factor 4 homolog (yeast).	0.409
ENSXMAP00000022713	prpf6	ENSXMAP00000022713	ENSXMAP00000015630	Small nuclear ribonucleoprotein-associated protein.	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae).	0.519
ENSXMAP00000022713	prpf8	ENSXMAP00000022713	ENSXMAP00000008559	Small nuclear ribonucleoprotein-associated protein.	Pre-mRNA processing factor 8.	0.479
ENSXMAP00000022713	sf3a1	ENSXMAP00000022713	ENSXMAP00000021464	Small nuclear ribonucleoprotein-associated protein.	Splicing factor 3a, subunit 1.	0.491
ENSXMAP00000022713	sf3a3	ENSXMAP00000022713	ENSXMAP00000031516	Small nuclear ribonucleoprotein-associated protein.	Splicing factor 3a, subunit 3.	0.412
ENSXMAP00000022713	sf3b1	ENSXMAP00000022713	ENSXMAP00000007412	Small nuclear ribonucleoprotein-associated protein.	Splicing factor 3b, subunit 1.	0.557
ENSXMAP00000022713	sf3b2	ENSXMAP00000022713	ENSXMAP00000008493	Small nuclear ribonucleoprotein-associated protein.	Splicing factor 3b, subunit 2.	0.494
ENSXMAP00000022713	sf3b3	ENSXMAP00000022713	ENSXMAP00000037050	Small nuclear ribonucleoprotein-associated protein.	Splicing factor 3b, subunit 3.	0.542
ENSXMAP00000022713	sf3b4	ENSXMAP00000022713	ENSXMAP00000003789	Small nuclear ribonucleoprotein-associated protein.	Splicing factor 3b, subunit 4.	0.567
ENSXMAP00000022713	sf3b5	ENSXMAP00000022713	ENSXMAP00000020018	Small nuclear ribonucleoprotein-associated protein.	Splicing factor 3B subunit 5; Belongs to the SF3B5 family.	0.473
ENSXMAP00000022713	snrpa1	ENSXMAP00000022713	ENSXMAP00000001459	Small nuclear ribonucleoprotein-associated protein.	Small nuclear ribonucleoprotein polypeptide A.	0.444
ENSXMAP00000022713	snrpd1	ENSXMAP00000022713	ENSXMAP00000003379	Small nuclear ribonucleoprotein-associated protein.	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family.	0.973
ENSXMAP00000022713	snrpd2	ENSXMAP00000022713	ENSXMAP00000001004	Small nuclear ribonucleoprotein-associated protein.	Small nuclear ribonucleoprotein Sm D2.	0.934
ENSXMAP00000022713	snrpd3	ENSXMAP00000022713	ENSXMAP00000001128	Small nuclear ribonucleoprotein-associated protein.	Small nuclear ribonucleoprotein Sm D3.	0.976