STRINGSTRING
SMAD3 SMAD3 LOC102236735 LOC102236735 skil skil itgb8 itgb8 LOC102216881 LOC102216881 LOC102225266 LOC102225266 itgb6 itgb6 stk16 stk16 LOC102223630 LOC102223630 crk crk pdcd5 pdcd5 LOC102223216 LOC102223216 smad6 smad6 smad3 smad3 LOC102226271 LOC102226271 TGFB3 TGFB3 LOC102221567 LOC102221567 LOC102224322 LOC102224322 LOC102218319 LOC102218319 LOC102228719 LOC102228719 rfwd3 rfwd3 dab2 dab2 LOC102218548 LOC102218548 nrros nrros appl1 appl1 sirt1 sirt1 LOC102229429 LOC102229429 smad9 smad9 LOC111611603 LOC111611603 M4A7K6_XIPMA M4A7K6_XIPMA clec3b clec3b LOC102233188 LOC102233188 LOC102237610 LOC102237610 acvr1 acvr1 flcn flcn nlk nlk TGFBR2 TGFBR2 tgfb3 tgfb3 M4ANT8_XIPMA M4ANT8_XIPMA fut8 fut8 appl2 appl2 LOC102219610 LOC102219610 LOC102219275 LOC102219275 smad2 smad2 LOC102225323 LOC102225323 LOC102227900 LOC102227900 ENSXMAP00000023172 ENSXMAP00000023172 cav1 cav1 LOC102222578 LOC102222578 LOC102235052 LOC102235052 cited1 cited1 LOC102231514 LOC102231514 tgfbr3 tgfbr3 lrrc32 lrrc32 SMAD4 SMAD4 ENSXMAP00000031631 ENSXMAP00000031631 smad1 smad1 Cldn5 Cldn5 crkl crkl ENSXMAP00000033320 ENSXMAP00000033320 LOC102237658 LOC102237658 sox6 sox6 ENSXMAP00000036468 ENSXMAP00000036468 smad7 smad7 bambi bambi zyx zyx hpgd hpgd LOC102218757 LOC102218757 tab1 tab1 LOC102227618 LOC102227618 sox5 sox5 LOC102216382 LOC102216382
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LOC102236735Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
skilSKI-like proto-oncogene a. (771 aa)
itgb8Integrin beta; Belongs to the integrin beta chain family. (760 aa)
LOC102216881Transforming growth factor beta; Belongs to the TGF-beta family. (394 aa)
LOC102225266Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (159 aa)
itgb6Integrin beta; Belongs to the integrin beta chain family. (665 aa)
stk16Serine/threonine kinase 16. (305 aa)
LOC102223630Mothers against decapentaplegic homolog. (507 aa)
crkCRK proto-oncogene, adaptor protein. (306 aa)
pdcd5Programmed cell death 5. (126 aa)
LOC102223216Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
smad6Mothers against decapentaplegic homolog. (492 aa)
smad3Mothers against decapentaplegic homolog. (425 aa)
LOC102226271JunE proto-oncogene, AP-1 transcription factor subunit. (324 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
LOC102221567Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
LOC102224322Mothers against decapentaplegic homolog. (467 aa)
LOC102218319Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (781 aa)
LOC102228719Mothers against decapentaplegic homolog. (503 aa)
rfwd3Golgi glycoprotein 1a. (1107 aa)
dab2DAB adaptor protein 2. (758 aa)
LOC102218548Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa)
nrrosNegative regulator of reactive oxygen species. (685 aa)
appl1Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. (708 aa)
sirt1Sirtuin 1. (694 aa)
LOC102229429Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
smad9Mothers against decapentaplegic homolog. (467 aa)
LOC111611603ZP domain-containing protein. (803 aa)
M4A7K6_XIPMAGolgi glycoprotein 1b. (679 aa)
clec3bC-type lectin domain family 3, member Ba. (198 aa)
LOC102233188Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (460 aa)
LOC102237610Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
acvr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (683 aa)
flcnFolliculin. (551 aa)
nlkMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (526 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (539 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
M4ANT8_XIPMAClaudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
fut8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (583 aa)
appl2Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2. (665 aa)
LOC102219610Ubiquitin specific peptidase 9; Belongs to the peptidase C19 family. (2490 aa)
LOC102219275Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (264 aa)
smad2Mothers against decapentaplegic homolog. (474 aa)
LOC102225323Mothers against decapentaplegic homolog. (563 aa)
LOC102227900Mothers against decapentaplegic homolog. (472 aa)
ENSXMAP00000023172Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (288 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
LOC102222578Uncharacterized protein. (652 aa)
LOC102235052Growth differentiation factor 11. (389 aa)
cited1Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1. (152 aa)
LOC102231514Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (598 aa)
tgfbr3Transforming growth factor, beta receptor III. (813 aa)
lrrc32Leucine rich repeat containing 32. (730 aa)
SMAD4Mothers against decapentaplegic homolog. (512 aa)
ENSXMAP00000031631Integrin_b_cyt domain-containing protein. (97 aa)
smad1Mothers against decapentaplegic homolog. (496 aa)
Cldn5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (165 aa)
crklV-crk avian sarcoma virus CT10 oncogene homolog-like. (299 aa)
ENSXMAP00000033320TGFb_propeptide domain-containing protein. (144 aa)
LOC102237658Myostatin a. (366 aa)
sox6SRY-box transcription factor 6. (775 aa)
ENSXMAP00000036468Uncharacterized protein. (103 aa)
smad7Mothers against decapentaplegic homolog. (378 aa)
bambiBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (259 aa)
zyxZyxin. (610 aa)
hpgd15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
LOC102218757Uncharacterized protein. (286 aa)
tab1TGF-beta activated kinase 1/MAP3K7 binding protein 1. (494 aa)
LOC102227618HMG box domain-containing protein. (780 aa)
sox5SRY-box transcription factor 5. (806 aa)
LOC102216382C-type lectin domain family 3, member Bb. (199 aa)
Your Current Organism:
Xiphophorus maculatus
NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish
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