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dis3l2 dis3l2 xrn2 xrn2 cnot6l cnot6l exd2 exd2 exosc2 exosc2 dcp2 dcp2 eri1 eri1 trir trir LOC102220704 LOC102220704 pan3 pan3 CNOT2 CNOT2 toe1 toe1 exosc10 exosc10 pan2 pan2 pde12 pde12 dis3l dis3l exosc7 exosc7 angel1 angel1 LOC102231225 LOC102231225 eri2 eri2 parn parn exosc3 exosc3 cnot8 cnot8 PNPT1 PNPT1 xrn1 xrn1 LOC102236754 LOC102236754 LOC102226828 LOC102226828 exosc9 exosc9 exosc8 exosc8 LOC102236546 LOC102236546 LOC102237197 LOC102237197 gnl3 gnl3 CPSF3 CPSF3 rexo2 rexo2 usb1 usb1 LOC102227457 LOC102227457 lrrc27 lrrc27 LOC102235957 LOC102235957 LOC102221587 LOC102221587 dis3 dis3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dis3l2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (942 aa)
xrn25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (967 aa)
cnot6lCCR4-NOT transcription complex, subunit 6-like. (552 aa)
exd2Exonuclease 3'-5' domain containing 2. (639 aa)
exosc2Exosome component 2. (293 aa)
dcp2Decapping mRNA 2. (398 aa)
eri1Exoribonuclease 1. (339 aa)
trirTelomerase RNA component interacting RNase. (148 aa)
LOC102220704Cleavage and polyadenylation specific factor 3. (686 aa)
pan3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (792 aa)
CNOT2CCR4-NOT transcription complex subunit 2. (525 aa)
toe1Target of EGR1, exonuclease. (505 aa)
exosc10Exosome component 10. (891 aa)
pan2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1206 aa)
pde12Phosphodiesterase 12. (587 aa)
dis3lDIS3 like exosome 3'-5' exoribonuclease. (903 aa)
exosc7Exosome component 7. (291 aa)
angel1Angel homolog 1 (Drosophila). (741 aa)
LOC102231225Zinc finger CCCH-type containing 12A. (624 aa)
eri2Exonuclease domain-containing protein. (252 aa)
parnPoly(A)-specific ribonuclease (deadenylation nuclease). (682 aa)
exosc3Exosome component 3. (245 aa)
cnot8CCR4-NOT transcription complex, subunit 8. (285 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (770 aa)
xrn15'-3' exoribonuclease 1. (1559 aa)
LOC102236754CCR4-NOT transcription complex, subunit 2. (517 aa)
LOC102226828Nocturnin. (385 aa)
exosc9Exosome component 9. (432 aa)
exosc8Exosome component 8. (288 aa)
LOC102236546Si:dkey-206d17.12. (541 aa)
LOC102237197Nocturnin. (445 aa)
gnl3Guanine nucleotide binding protein-like 3 (nucleolar). (550 aa)
CPSF3Cleavage and polyadenylation specific factor 3. (737 aa)
rexo2Small fragment nuclease. (312 aa)
usb1U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family. (365 aa)
LOC102227457CCR4-NOT transcription complex, subunit 7. (286 aa)
lrrc27Uncharacterized protein. (395 aa)
LOC102235957CCR4-NOT transcription complex, subunit 6a. (558 aa)
LOC102221587Angel homolog 2 (Drosophila). (535 aa)
dis3DIS3 exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (951 aa)
Your Current Organism:
Xiphophorus maculatus
NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish
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