(54 nodes) Cellular response to alcohol network (Xiphophorus maculatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102226016	Junction plakoglobin a. (721 aa)
	glra1	Glycine receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (468 aa)
	podn	Podocan. (587 aa)
	LOC102230847	Glycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (455 aa)
	LOC102236064	Si:dkey-6n21.13; Belongs to the G-protein coupled receptor 1 family. (385 aa)
	LOC102221787	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (547 aa)
	ENSXMAP00000040223	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (483 aa)
	ache	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (616 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
	adcy5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1211 aa)
	LOC102231024	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1195 aa)
	LOC102236399	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1188 aa)
	golph3	Golgi phosphoprotein 3. (293 aa)
	ptger2	Prostaglandin E receptor 2a (subtype EP2). (385 aa)
	P2RY6	Pyrimidinergic receptor P2Y6; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	gramd1a	GRAM domain containing 1A. (905 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
	LOC102229138	Si:dkey-27b3.2. (294 aa)
	blm	BLM RecQ like helicase. (1398 aa)
	LOC102236248	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (452 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1503 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (292 aa)
	ptgir	Prostaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	mlc1	Modulator of VRAC current 1. (402 aa)
	LOC102223235	Uncharacterized protein. (354 aa)
	LOC102231381	Prostaglandin E receptor 4 (subtype EP4) b. (454 aa)
	ENSXMAP00000023259	Uncharacterized protein. (127 aa)
	gramd1b	GRAM domain containing 1Bb. (918 aa)
	M4B0L0_XIPMA	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (526 aa)
	SPIDR	Scaffold protein involved in DNA repair. (930 aa)
	glra2	Glycine receptor, alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
	adcy3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
	LOC102230034	Uncharacterized protein. (354 aa)
	LOC102223893	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
	LOC102232616	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1128 aa)
	LOC102223293	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (601 aa)
	LOC102220874	Homeobox domain-containing protein. (306 aa)
	brca1	Uncharacterized protein. (1370 aa)
	gramd1c	GRAM domain containing 1c. (657 aa)
	LOC102235040	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1179 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (811 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (629 aa)
	LOC102216828	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1460 aa)
	xrn1	5'-3' exoribonuclease 1. (1559 aa)
	glra3	Glycine receptor, alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (468 aa)
	adcy6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1207 aa)
	LOC102227141	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1151 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (564 aa)
	LOC102233202	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (411 aa)
	otx2	Orthodenticle homeobox 2b. (290 aa)
	ptgfr	Prostaglandin F receptor (FP). (364 aa)
	LOC102235498	Glycine receptor, alpha 4b; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
	aifm1	Apoptosis inducing factor mitochondrion associated 1. (650 aa)
	recql5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (992 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSXMAP00000040223	ptger2	ENSXMAP00000040223	ENSXMAP00000029509	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family.	Prostaglandin E receptor 2a (subtype EP2).	0.518
ENSXMAP00000040223	ptgir	ENSXMAP00000040223	ENSXMAP00000025247	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family.	Prostaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family.	0.433
LOC102223235	LOC102223893	ENSXMAP00000024053	ENSXMAP00000004848	Uncharacterized protein.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.435
LOC102223235	LOC102227141	ENSXMAP00000024053	ENSXMAP00000016963	Uncharacterized protein.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.794
LOC102223235	LOC102231024	ENSXMAP00000024053	ENSXMAP00000003460	Uncharacterized protein.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.780
LOC102223235	LOC102232616	ENSXMAP00000024053	ENSXMAP00000006333	Uncharacterized protein.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.794
LOC102223235	LOC102235040	ENSXMAP00000024053	ENSXMAP00000010735	Uncharacterized protein.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.768
LOC102223235	LOC102236399	ENSXMAP00000024053	ENSXMAP00000003653	Uncharacterized protein.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.780
LOC102223235	adcy3	ENSXMAP00000024053	ENSXMAP00000004386	Uncharacterized protein.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.794
LOC102223235	adcy5	ENSXMAP00000024053	ENSXMAP00000000767	Uncharacterized protein.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.768
LOC102223235	adcy6	ENSXMAP00000024053	ENSXMAP00000017376	Uncharacterized protein.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.768
LOC102223235	adcy8	ENSXMAP00000024053	ENSXMAP00000028309	Uncharacterized protein.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.780
LOC102223235	smo	ENSXMAP00000024053	ENSXMAP00000011040	Uncharacterized protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.512
LOC102223293	ache	ENSXMAP00000006356	ENSXMAP00000011941	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.912
LOC102223893	LOC102223235	ENSXMAP00000004848	ENSXMAP00000024053	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.435
LOC102223893	LOC102230034	ENSXMAP00000004848	ENSXMAP00000004758	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.435
LOC102223893	LOC102231024	ENSXMAP00000004848	ENSXMAP00000003460	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.451
LOC102223893	LOC102235040	ENSXMAP00000004848	ENSXMAP00000010735	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.433
LOC102223893	LOC102236399	ENSXMAP00000004848	ENSXMAP00000003653	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.451
LOC102223893	adcy5	ENSXMAP00000004848	ENSXMAP00000000767	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.432