(13 nodes) Disordered domain specific binding network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fkbp8	Peptidylprolyl isomerase. (396 aa)
	LOC102226183	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1685 aa)
	LOC102226519	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1677 aa)
	LOC102231067	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (926 aa)
	LOC102230011	Fibronectin 1a. (2488 aa)
	dffb	DNA fragmentation factor, beta polypeptide (caspase-activated DNase). (346 aa)
	LOC102218115	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2. (733 aa)
	LOC102218377	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1. (724 aa)
	cltcl1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1616 aa)
	LOC102219317	Heat shock protein 90, alpha (cytosolic), class B member 1. (723 aa)
	LOC102217752	Peptidylprolyl isomerase. (467 aa)
	rb1	Retinoblastoma susceptibility protein. (912 aa)
	numa1	Calponin-homology (CH) domain-containing protein. (2533 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102217752	LOC102218115	ENSXMAP00000029573	ENSXMAP00000008332	Peptidylprolyl isomerase.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	0.652
LOC102217752	LOC102218377	ENSXMAP00000029573	ENSXMAP00000008338	Peptidylprolyl isomerase.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.652
LOC102217752	LOC102219317	ENSXMAP00000029573	ENSXMAP00000017367	Peptidylprolyl isomerase.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.652
LOC102218115	LOC102217752	ENSXMAP00000008332	ENSXMAP00000029573	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Peptidylprolyl isomerase.	0.652
LOC102218115	LOC102218377	ENSXMAP00000008332	ENSXMAP00000008338	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.900
LOC102218115	LOC102219317	ENSXMAP00000008332	ENSXMAP00000017367	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.938
LOC102218115	fkbp8	ENSXMAP00000008332	ENSXMAP00000012908	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Peptidylprolyl isomerase.	0.652
LOC102218377	LOC102217752	ENSXMAP00000008338	ENSXMAP00000029573	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Peptidylprolyl isomerase.	0.652
LOC102218377	LOC102218115	ENSXMAP00000008338	ENSXMAP00000008332	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	0.900
LOC102218377	LOC102219317	ENSXMAP00000008338	ENSXMAP00000017367	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.938
LOC102218377	fkbp8	ENSXMAP00000008338	ENSXMAP00000012908	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	Peptidylprolyl isomerase.	0.652
LOC102219317	LOC102217752	ENSXMAP00000017367	ENSXMAP00000029573	Heat shock protein 90, alpha (cytosolic), class B member 1.	Peptidylprolyl isomerase.	0.652
LOC102219317	LOC102218115	ENSXMAP00000017367	ENSXMAP00000008332	Heat shock protein 90, alpha (cytosolic), class B member 1.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	0.938
LOC102219317	LOC102218377	ENSXMAP00000017367	ENSXMAP00000008338	Heat shock protein 90, alpha (cytosolic), class B member 1.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.938
LOC102219317	fkbp8	ENSXMAP00000017367	ENSXMAP00000012908	Heat shock protein 90, alpha (cytosolic), class B member 1.	Peptidylprolyl isomerase.	0.652
LOC102226183	LOC102226519	ENSXMAP00000000183	ENSXMAP00000001070	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.900
LOC102226183	LOC102231067	ENSXMAP00000000183	ENSXMAP00000001071	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.919
LOC102226183	cltcl1	ENSXMAP00000000183	ENSXMAP00000014461	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.900
LOC102226519	LOC102226183	ENSXMAP00000001070	ENSXMAP00000000183	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.900
LOC102226519	LOC102231067	ENSXMAP00000001070	ENSXMAP00000001071	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.919