(124 nodes) Meiotic cell cycle process network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSXMAP00000040204	HTH_Tnp_Tc3_2 domain-containing protein. (181 aa)
	ENSXMAP00000039864	annotation not available (331 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1312 aa)
	fbxo5	F-box protein 5. (409 aa)
	ENSXMAP00000039404	HTH_Tnp_Tc3_2 domain-containing protein. (238 aa)
	mnd1	Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (199 aa)
	ENSXMAP00000038993	Uncharacterized protein. (335 aa)
	LOC102221792	UF2 component of NDC80 kinetochore complex. (449 aa)
	ENSXMAP00000038311	Uncharacterized protein. (297 aa)
	LOC102219904	Spire-type actin nucleation factor 1b. (883 aa)
	ENSXMAP00000036829	Uncharacterized protein. (329 aa)
	ENSXMAP00000036808	HTH_Tnp_Tc3_2 domain-containing protein. (260 aa)
	ENSXMAP00000036521	DDE_3 domain-containing protein. (201 aa)
	ENSXMAP00000035974	annotation not available (331 aa)
	Ncaph2	CNDH2_N domain-containing protein. (56 aa)
	ENSXMAP00000035484	Zebrafish testis-expressed 38. (263 aa)
	ccnb1ip1	Cyclin B1 interacting protein 1. (264 aa)
	ENSXMAP00000033187	Uncharacterized protein. (331 aa)
	ENSXMAP00000032734	Uncharacterized protein. (331 aa)
	ENSXMAP00000032715	Uncharacterized protein. (297 aa)
	ENSXMAP00000032679	Uncharacterized protein. (387 aa)
	ENSXMAP00000032514	Uncharacterized protein. (331 aa)
	ENSXMAP00000032264	Uncharacterized protein. (331 aa)
	mlh3	MutL homolog 3 (E. coli). (1151 aa)
	LOC111610367	ANK_REP_REGION domain-containing protein. (488 aa)
	LOC111607145	Uncharacterized protein. (362 aa)
	ENSXMAP00000031814	Uncharacterized protein. (331 aa)
	ENSXMAP00000031754	Uncharacterized protein. (244 aa)
	msh4	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (912 aa)
	ENSXMAP00000031216	DDE_3 domain-containing protein. (165 aa)
	syce3	Uncharacterized protein. (98 aa)
	hsf2bp	Heat shock transcription factor 2 binding protein. (338 aa)
	rad1	RAD1 homolog (S. pombe). (289 aa)
	rec8	Uncharacterized protein. (541 aa)
	psmc3ip	PSMC3 interacting protein. (220 aa)
	LOC111611385	Uncharacterized protein. (612 aa)
	MARF1	Meiosis regulator and mRNA stability factor 1. (1769 aa)
	ENSXMAP00000028786	annotation not available (331 aa)
	ENSXMAP00000028709	Uncharacterized protein. (78 aa)
	ENSXMAP00000028253	Si:dkey-40g16.5. (135 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (475 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (754 aa)
	ankle1	Zgc:85936. (1142 aa)
	ENSXMAP00000025991	annotation not available (331 aa)
	slx4	BTB domain-containing protein. (1245 aa)
	ENSXMAP00000025468	Uncharacterized protein. (223 aa)
	ENSXMAP00000025425	Tudor domain containing 12. (989 aa)
	ENSXMAP00000025155	Uncharacterized protein. (331 aa)
	ENSXMAP00000024369	Uncharacterized protein. (387 aa)
	ENSXMAP00000023735	Uncharacterized protein. (366 aa)
	ENSXMAP00000023613	Uncharacterized protein. (333 aa)
	ccne2	Cyclin E2; Belongs to the cyclin family. (394 aa)
	ENSXMAP00000021866	DDE_3 domain-containing protein. (145 aa)
	LOC111608004	Uncharacterized protein. (329 aa)
	ENSXMAP00000021046	DDE_3 domain-containing protein. (158 aa)
	terb2	Telomere repeat binding bouquet formation protein 2. (211 aa)
	LOC102223278	Spire-type actin nucleation factor 1a. (789 aa)
	psmd13	Proteasome 26S subunit, non-ATPase 13. (378 aa)
	smc4	Structural maintenance of chromosomes protein. (1326 aa)
	tdrd9	Tudor domain containing 9. (1268 aa)
	spo11	SPO11 initiator of meiotic double stranded breaks. (387 aa)
	LOC102224555	Forkhead box J3. (604 aa)
	top2b	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1589 aa)
	atm	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2875 aa)
	LOC102221752	Fork-head domain-containing protein. (601 aa)
	edn1	Endothelin 1. (197 aa)
	spire2	Spire-type actin nucleation factor 2. (771 aa)
	ercc1	Excision repair cross-complementation group 1. (350 aa)
	rmi1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (680 aa)
	tdrkh	Tudor and KH domain containing. (539 aa)
	asz1	Ankyrin repeat, SAM and basic leucine zipper domain containing 1. (421 aa)
	trip13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (420 aa)
	tubg1	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (451 aa)
	LOC102217509	Uncharacterized protein. (177 aa)
	bag6	BCL2 associated athanogene 6. (1212 aa)
	LOC102221997	Testis expressed 11. (807 aa)
	msh5	MutS homolog 5. (787 aa)
	sirt7	Sirtuin 7. (408 aa)
	hus1	Checkpoint protein; Belongs to the HUS1 family. (271 aa)
	ndc1	NDC1 transmembrane nucleoporin. (669 aa)
	dmc1	DNA meiotic recombinase 1; Belongs to the RecA family. (274 aa)
	Cenpx	Uncharacterized protein. (63 aa)
	espl1	Extra spindle pole bodies like 1, separase. (2165 aa)
	LOC102233674	Uncharacterized protein. (1901 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
	mos	V-mos Moloney murine sarcoma viral oncogene homolog; Belongs to the protein kinase superfamily. (337 aa)
	fancd2	FA complementation group D2. (1235 aa)
	meiob	Methionine sulfoxide reductase B1b. (425 aa)
	eme1	Essential meiotic structure-specific endonuclease 1. (536 aa)
	LOC102236202	Bromodomain, testis-specific. (916 aa)
	rad51d	RAD51 paralog D. (339 aa)
	ncapd2	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1370 aa)
	top2a	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1536 aa)
	LOC102218059	Baculoviral IAP repeat containing 5a. (142 aa)
	C1orf146	Chromosome 1 open reading frame 146. (172 aa)
	LOC102226637	EGF-like domain-containing protein. (153 aa)
	ncaph	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (726 aa)
	mus81	MUS81 structure-specific endonuclease subunit. (617 aa)
	EME2	ERCC4 domain-containing protein. (438 aa)
	ednra	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (444 aa)
	Atrx	ATRX chromatin remodeler. (1195 aa)
	M4A3H1_XIPMA	HORMA domain containing 1. (241 aa)
	majin	Membrane anchored junction protein. (241 aa)
	ercc4	Excision repair cross-complementation group 4. (893 aa)
	Meioc	Uncharacterized protein. (219 aa)
	fancm	Uncharacterized protein. (1911 aa)
	ttk	Ttk protein kinase. (916 aa)
	brca2	BRCA2 DNA repair associated. (3052 aa)
	bub1b	BUB1 mitotic checkpoint serine/threonine kinase Bb. (430 aa)
	ncapd3	Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. (1404 aa)
	smc2	Structural maintenance of chromosomes protein. (1200 aa)
	Terb1	Uncharacterized protein. (337 aa)
	M3ZPQ6_XIPMA	Helicase for meiosis 1. (869 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (743 aa)
	incenp	Uncharacterized protein. (752 aa)
	KIF18A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (876 aa)
	LOC102224556	Uncharacterized protein. (192 aa)
	rad51c	RAD51 paralog C. (352 aa)
	SGO1	Shugoshin_C domain-containing protein. (636 aa)
	ENSXMAP00000041423	PR domain containing 9. (740 aa)
	bcl2l11	Uncharacterized protein. (250 aa)
	ENSXMAP00000040970	Uncharacterized protein. (331 aa)
	Bub1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (210 aa)
	ENSXMAP00000040306	Uncharacterized protein. (102 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atrx	atm	ENSXMAP00000009158	ENSXMAP00000016978	ATRX chromatin remodeler.	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.507
Atrx	brca2	ENSXMAP00000009158	ENSXMAP00000006983	ATRX chromatin remodeler.	BRCA2 DNA repair associated.	0.416
Atrx	bub1b	ENSXMAP00000009158	ENSXMAP00000006577	ATRX chromatin remodeler.	BUB1 mitotic checkpoint serine/threonine kinase Bb.	0.479
Atrx	ercc4	ENSXMAP00000009158	ENSXMAP00000007941	ATRX chromatin remodeler.	Excision repair cross-complementation group 4.	0.421
Atrx	fancm	ENSXMAP00000009158	ENSXMAP00000007734	ATRX chromatin remodeler.	Uncharacterized protein.	0.750
Atrx	mre11	ENSXMAP00000009158	ENSXMAP00000004014	ATRX chromatin remodeler.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.433
Atrx	mus81	ENSXMAP00000009158	ENSXMAP00000009908	ATRX chromatin remodeler.	MUS81 structure-specific endonuclease subunit.	0.572
Atrx	rad51	ENSXMAP00000009158	ENSXMAP00000000592	ATRX chromatin remodeler.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.815
Atrx	rad51c	ENSXMAP00000009158	ENSXMAP00000003353	ATRX chromatin remodeler.	RAD51 paralog C.	0.447
Atrx	rad51d	ENSXMAP00000009158	ENSXMAP00000011507	ATRX chromatin remodeler.	RAD51 paralog D.	0.532
Bub1	ENSXMAP00000023735	ENSXMAP00000040519	ENSXMAP00000023735	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.761
Bub1	ENSXMAP00000024369	ENSXMAP00000040519	ENSXMAP00000024369	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.761
Bub1	ENSXMAP00000032679	ENSXMAP00000040519	ENSXMAP00000032679	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.761
Bub1	ENSXMAP00000032715	ENSXMAP00000040519	ENSXMAP00000032715	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.761
Bub1	ENSXMAP00000038311	ENSXMAP00000040519	ENSXMAP00000038311	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.761
Bub1	KIF18A	ENSXMAP00000040519	ENSXMAP00000003795	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.848
Bub1	LOC102217509	ENSXMAP00000040519	ENSXMAP00000013721	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.758
Bub1	LOC102218059	ENSXMAP00000040519	ENSXMAP00000011162	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Baculoviral IAP repeat containing 5a.	0.873
Bub1	LOC102221792	ENSXMAP00000040519	ENSXMAP00000038811	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	UF2 component of NDC80 kinetochore complex.	0.808
Bub1	LOC111608004	ENSXMAP00000040519	ENSXMAP00000021386	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.761