STRINGSTRING
myf5 myf5 pcgf1 pcgf1 LOC102222872 LOC102222872 LOC102225329 LOC102225329 M3ZX48_XIPMA M3ZX48_XIPMA M3ZXZ2_XIPMA M3ZXZ2_XIPMA sirt1 sirt1 ercc4 ercc4 kdm1a kdm1a EZH1 EZH1 dhx9 dhx9 znf750 znf750 prdm1 prdm1 PRDM15 PRDM15 gtf2f1 gtf2f1 rbl1 rbl1 polr2a polr2a ercc1 ercc1 setdb1 setdb1 pcgf2 pcgf2 wdr13 wdr13 taf10 taf10 egr1 egr1 LOC102218576 LOC102218576 ENSXMAP00000023550 ENSXMAP00000023550 med1 med1 ENSXMAP00000026894 ENSXMAP00000026894 gtf2b gtf2b tp53 tp53 LOC102228854 LOC102228854 Nup98 Nup98 ENSXMAP00000032417 ENSXMAP00000032417 Ezh2 Ezh2 LOC102231331 LOC102231331 LOC102222564 LOC102222564 dnmt1 dnmt1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
myf5Myogenic factor. (233 aa)
pcgf1Polycomb group ring finger 1. (260 aa)
LOC102222872Uncharacterized protein. (783 aa)
LOC102225329Retinoblastoma-like 2 (p130). (1063 aa)
M3ZX48_XIPMAUncharacterized protein. (352 aa)
M3ZXZ2_XIPMABmi1 polycomb ring finger oncogene 1a. (345 aa)
sirt1Sirtuin 1. (694 aa)
ercc4Excision repair cross-complementation group 4. (893 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (830 aa)
EZH1Enhancer of zeste 1 polycomb repressive complex 2 subunit. (770 aa)
dhx9DEAH (Asp-Glu-Ala-His) box helicase 9. (1246 aa)
znf750Zinc finger protein 750. (600 aa)
prdm1PR domain containing 1a, with ZNF domain. (842 aa)
PRDM15PR/SET domain 15. (1096 aa)
gtf2f1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (497 aa)
rbl1Retinoblastoma-like 1 (p107). (1055 aa)
polr2aDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1966 aa)
ercc1Excision repair cross-complementation group 1. (350 aa)
setdb1SET domain bifurcated histone lysine methyltransferase 1b. (1253 aa)
pcgf2Polycomb group ring finger 2. (333 aa)
wdr13WD repeat domain 13. (482 aa)
taf10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (186 aa)
egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (512 aa)
LOC102218576PR domain containing 1b, with ZNF domain. (761 aa)
ENSXMAP00000023550Peptidase S59 domain-containing protein. (211 aa)
med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1745 aa)
ENSXMAP00000026894Uncharacterized protein. (342 aa)
gtf2bGeneral transcription factor IIB. (318 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (342 aa)
LOC102228854Interferon regulatory factor 3. (465 aa)
Nup98Nup96 domain-containing protein. (374 aa)
ENSXMAP00000032417Uncharacterized protein. (158 aa)
Ezh2Uncharacterized protein. (92 aa)
LOC102231331MBD domain-containing protein. (1180 aa)
LOC102222564Myogenic factor. (355 aa)
dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1499 aa)
Your Current Organism:
Xiphophorus maculatus
NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish
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