(16 nodes) Replisome network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102230232	RPA_C domain-containing protein. (247 aa)
	rpa3	Replication protein A3. (122 aa)
	pola1	DNA polymerase. (1488 aa)
	dars2	Aspartyl-tRNA synthetase 2, mitochondrial. (657 aa)
	prim1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (528 aa)
	DONSON	Downstream neighbor of SON. (584 aa)
	rpa2	Replication protein A2. (278 aa)
	pold1	DNA polymerase. (1105 aa)
	pold4	Si:dkey-28b4.7. (108 aa)
	cdc6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (579 aa)
	pola2	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa)
	prim2	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (501 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
	cdt1	Chromatin licensing and DNA replication factor 1. (761 aa)
	c5h19orf53	Zgc:136864. (97 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DONSON	cdt1	ENSXMAP00000004418	ENSXMAP00000038454	Downstream neighbor of SON.	Chromatin licensing and DNA replication factor 1.	0.453
DONSON	pola2	ENSXMAP00000004418	ENSXMAP00000009802	Downstream neighbor of SON.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.500
DONSON	pold2	ENSXMAP00000004418	ENSXMAP00000015386	Downstream neighbor of SON.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.632
DONSON	prim2	ENSXMAP00000004418	ENSXMAP00000009429	Downstream neighbor of SON.	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.	0.682
LOC102230232	cdc6	ENSXMAP00000035005	ENSXMAP00000014196	RPA_C domain-containing protein.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.614
LOC102230232	pola1	ENSXMAP00000035005	ENSXMAP00000022844	RPA_C domain-containing protein.	DNA polymerase.	0.808
LOC102230232	pola2	ENSXMAP00000035005	ENSXMAP00000009802	RPA_C domain-containing protein.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.804
LOC102230232	pold1	ENSXMAP00000035005	ENSXMAP00000011793	RPA_C domain-containing protein.	DNA polymerase.	0.692
LOC102230232	pold2	ENSXMAP00000035005	ENSXMAP00000015386	RPA_C domain-containing protein.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.652
LOC102230232	prim1	ENSXMAP00000035005	ENSXMAP00000017475	RPA_C domain-containing protein.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.854
LOC102230232	prim2	ENSXMAP00000035005	ENSXMAP00000009429	RPA_C domain-containing protein.	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.	0.860
LOC102230232	rpa2	ENSXMAP00000035005	ENSXMAP00000014581	RPA_C domain-containing protein.	Replication protein A2.	0.905
LOC102230232	rpa3	ENSXMAP00000035005	ENSXMAP00000031677	RPA_C domain-containing protein.	Replication protein A3.	0.991
cdc6	LOC102230232	ENSXMAP00000014196	ENSXMAP00000035005	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	RPA_C domain-containing protein.	0.614
cdc6	cdt1	ENSXMAP00000014196	ENSXMAP00000038454	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Chromatin licensing and DNA replication factor 1.	0.999
cdc6	pola1	ENSXMAP00000014196	ENSXMAP00000022844	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	DNA polymerase.	0.901
cdc6	pola2	ENSXMAP00000014196	ENSXMAP00000009802	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.917
cdc6	pold1	ENSXMAP00000014196	ENSXMAP00000011793	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	DNA polymerase.	0.881
cdc6	prim1	ENSXMAP00000014196	ENSXMAP00000017475	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.922
cdc6	prim2	ENSXMAP00000014196	ENSXMAP00000009429	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.	0.890