(13 nodes) Thiamin diphosphate-binding fold network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pdha1	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (455 aa)
	dhtkd1	Dehydrogenase E1 and transketolase domain containing 1. (924 aa)
	TKT	Transketolase. (628 aa)
	LOC102224760	Transketolase a. (628 aa)
	LOC102234273	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
	ogdh	Oxoglutarate (alpha-ketoglutarate) dehydrogenase b (lipoamide). (1022 aa)
	OGDH	Oxoglutarate dehydrogenase. (1036 aa)
	ilvbl	IlvB (bacterial acetolactate synthase)-like; Belongs to the TPP enzyme family. (625 aa)
	bckdhb	Branched chain keto acid dehydrogenase E1 subunit beta. (387 aa)
	bckdha	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (447 aa)
	LOC102234635	Transketolase b. (626 aa)
	pdhb	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (360 aa)
	hacl1	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (572 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102224760	LOC102234273	ENSXMAP00000017095	ENSXMAP00000040857	Transketolase a.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.875
LOC102224760	LOC102234635	ENSXMAP00000017095	ENSXMAP00000008365	Transketolase a.	Transketolase b.	0.901
LOC102224760	TKT	ENSXMAP00000017095	ENSXMAP00000020891	Transketolase a.	Transketolase.	0.900
LOC102224760	bckdha	ENSXMAP00000017095	ENSXMAP00000007681	Transketolase a.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.726
LOC102224760	bckdhb	ENSXMAP00000017095	ENSXMAP00000007085	Transketolase a.	Branched chain keto acid dehydrogenase E1 subunit beta.	0.480
LOC102224760	hacl1	ENSXMAP00000017095	ENSXMAP00000013896	Transketolase a.	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family.	0.519
LOC102224760	ilvbl	ENSXMAP00000017095	ENSXMAP00000001380	Transketolase a.	IlvB (bacterial acetolactate synthase)-like; Belongs to the TPP enzyme family.	0.519
LOC102224760	pdha1	ENSXMAP00000017095	ENSXMAP00000025748	Transketolase a.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.875
LOC102224760	pdhb	ENSXMAP00000017095	ENSXMAP00000008844	Transketolase a.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.891
LOC102234273	LOC102224760	ENSXMAP00000040857	ENSXMAP00000017095	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Transketolase a.	0.875
LOC102234273	LOC102234635	ENSXMAP00000040857	ENSXMAP00000008365	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Transketolase b.	0.875
LOC102234273	OGDH	ENSXMAP00000040857	ENSXMAP00000031299	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Oxoglutarate dehydrogenase.	0.781
LOC102234273	TKT	ENSXMAP00000040857	ENSXMAP00000020891	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Transketolase.	0.875
LOC102234273	bckdha	ENSXMAP00000040857	ENSXMAP00000007681	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.708
LOC102234273	bckdhb	ENSXMAP00000040857	ENSXMAP00000007085	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Branched chain keto acid dehydrogenase E1 subunit beta.	0.982
LOC102234273	dhtkd1	ENSXMAP00000040857	ENSXMAP00000021339	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Dehydrogenase E1 and transketolase domain containing 1.	0.681
LOC102234273	ogdh	ENSXMAP00000040857	ENSXMAP00000018936	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Oxoglutarate (alpha-ketoglutarate) dehydrogenase b (lipoamide).	0.781
LOC102234273	pdha1	ENSXMAP00000040857	ENSXMAP00000025748	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.901
LOC102234273	pdhb	ENSXMAP00000040857	ENSXMAP00000008844	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.999
LOC102234635	LOC102224760	ENSXMAP00000008365	ENSXMAP00000017095	Transketolase b.	Transketolase a.	0.901