(31 nodes) Translesion Synthesis by POLH network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rfc1	Replication factor C subunit 1. (1195 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (700 aa)
	polh	Polymerase (DNA directed), eta. (720 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	meiob	Methionine sulfoxide reductase B1b. (425 aa)
	LOC102234371	Zgc:136908; Belongs to the AAA ATPase family. (810 aa)
	LOC102230076	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
	LOC102218031	ATPase family AAA domain containing 5a. (1810 aa)
	rpa2	Replication protein A2. (278 aa)
	nploc4	NPL4 homolog, ubiquitin recognition factor. (630 aa)
	rfc2	Replication factor C (activator 1) 2. (357 aa)
	ufd1	Ubiquitin recognition factor in ER associated degradation 1. (311 aa)
	rchy1	Ring finger and CHY zinc finger domain containing 1. (272 aa)
	ubb	Ubiquitin B. (838 aa)
	SPATA5	Spermatogenesis associated 5. (900 aa)
	rcbtb2	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	vcp	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
	Uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (355 aa)
	sprtn	SprT-like N-terminal domain. (534 aa)
	rpa3	Replication protein A3. (122 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	ENSXMAP00000036141	Ubiquitin-like domain-containing protein. (75 aa)
	LOC102230232	RPA_C domain-containing protein. (247 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	spata5l1	Spermatogenesis associated 5-like 1. (748 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	LOC102228530	Si:dkey-24l11.2. (653 aa)
	kxd1	KxDL motif containing 1. (184 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSXMAP00000036141	LOC102230232	ENSXMAP00000036141	ENSXMAP00000035005	Ubiquitin-like domain-containing protein.	RPA_C domain-containing protein.	0.471
ENSXMAP00000036141	LOC102234371	ENSXMAP00000036141	ENSXMAP00000012347	Ubiquitin-like domain-containing protein.	Zgc:136908; Belongs to the AAA ATPase family.	0.732
ENSXMAP00000036141	SPATA5	ENSXMAP00000036141	ENSXMAP00000018399	Ubiquitin-like domain-containing protein.	Spermatogenesis associated 5.	0.732
ENSXMAP00000036141	nploc4	ENSXMAP00000036141	ENSXMAP00000014597	Ubiquitin-like domain-containing protein.	NPL4 homolog, ubiquitin recognition factor.	0.825
ENSXMAP00000036141	pcna	ENSXMAP00000036141	ENSXMAP00000014924	Ubiquitin-like domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.918
ENSXMAP00000036141	polh	ENSXMAP00000036141	ENSXMAP00000010617	Ubiquitin-like domain-containing protein.	Polymerase (DNA directed), eta.	0.778
ENSXMAP00000036141	rpa2	ENSXMAP00000036141	ENSXMAP00000014581	Ubiquitin-like domain-containing protein.	Replication protein A2.	0.471
ENSXMAP00000036141	rps27a	ENSXMAP00000036141	ENSXMAP00000000166	Ubiquitin-like domain-containing protein.	Ribosomal protein S27a.	0.994
ENSXMAP00000036141	spata5l1	ENSXMAP00000036141	ENSXMAP00000002301	Ubiquitin-like domain-containing protein.	Spermatogenesis associated 5-like 1.	0.732
ENSXMAP00000036141	sprtn	ENSXMAP00000036141	ENSXMAP00000033136	Ubiquitin-like domain-containing protein.	SprT-like N-terminal domain.	0.649
ENSXMAP00000036141	ubb	ENSXMAP00000036141	ENSXMAP00000023177	Ubiquitin-like domain-containing protein.	Ubiquitin B.	0.964
ENSXMAP00000036141	ufd1	ENSXMAP00000036141	ENSXMAP00000026549	Ubiquitin-like domain-containing protein.	Ubiquitin recognition factor in ER associated degradation 1.	0.811
ENSXMAP00000036141	vcp	ENSXMAP00000036141	ENSXMAP00000007519	Ubiquitin-like domain-containing protein.	Valosin containing protein; Belongs to the AAA ATPase family.	0.732
LOC102218031	LOC102230232	ENSXMAP00000014316	ENSXMAP00000035005	ATPase family AAA domain containing 5a.	RPA_C domain-containing protein.	0.589
LOC102218031	LOC102234371	ENSXMAP00000014316	ENSXMAP00000012347	ATPase family AAA domain containing 5a.	Zgc:136908; Belongs to the AAA ATPase family.	0.497
LOC102218031	RPA1	ENSXMAP00000014316	ENSXMAP00000010389	ATPase family AAA domain containing 5a.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.743
LOC102218031	SPATA5	ENSXMAP00000014316	ENSXMAP00000018399	ATPase family AAA domain containing 5a.	Spermatogenesis associated 5.	0.497
LOC102218031	meiob	ENSXMAP00000014316	ENSXMAP00000011795	ATPase family AAA domain containing 5a.	Methionine sulfoxide reductase B1b.	0.743
LOC102218031	pcna	ENSXMAP00000014316	ENSXMAP00000014924	ATPase family AAA domain containing 5a.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.981
LOC102218031	polh	ENSXMAP00000014316	ENSXMAP00000010617	ATPase family AAA domain containing 5a.	Polymerase (DNA directed), eta.	0.691