STRINGSTRING
LOC102217251 LOC102217251 pold3 pold3 ruvbl2 ruvbl2 lig1 lig1 rtel1 rtel1 LOC102220076 LOC102220076 LOC102237263 LOC102237263 exd2 exd2 LOC102224578 LOC102224578 cdk2 cdk2 PPP6C PPP6C rfc5 rfc5 gar1 gar1 ccna2 ccna2 LOC102237630 LOC102237630 HIST1H2BA HIST1H2BA ENSXMAP00000020862 ENSXMAP00000020862 ENSXMAP00000021083 ENSXMAP00000021083 ctc1 ctc1 LOC111609624 LOC111609624 ENSXMAP00000022343 ENSXMAP00000022343 pola1 pola1 ENSXMAP00000023013 ENSXMAP00000023013 ENSXMAP00000023263 ENSXMAP00000023263 dkc1 dkc1 rbpms2 rbpms2 ENSXMAP00000024331 ENSXMAP00000024331 ten1 ten1 LOC102230647 LOC102230647 ankrd44 ankrd44 ENSXMAP00000025747 ENSXMAP00000025747 ENSXMAP00000025754 ENSXMAP00000025754 ENSXMAP00000025960 ENSXMAP00000025960 ENSXMAP00000026410 ENSXMAP00000026410 ENSXMAP00000026594 ENSXMAP00000026594 ENSXMAP00000032360 ENSXMAP00000032360 ENSXMAP00000032554 ENSXMAP00000032554 ENSXMAP00000033462 ENSXMAP00000033462 ENSXMAP00000033576 ENSXMAP00000033576 LOC102230232 LOC102230232 LOC102237858 LOC102237858 ENSXMAP00000035797 ENSXMAP00000035797 ENSXMAP00000036123 ENSXMAP00000036123 ENSXMAP00000036529 ENSXMAP00000036529 ENSXMAP00000036593 ENSXMAP00000036593 rpa1 rpa1 pot1 pot1 ENSXMAP00000038433 ENSXMAP00000038433 ENSXMAP00000038955 ENSXMAP00000038955 ENSXMAP00000040449 ENSXMAP00000040449 rfc3 rfc3 ENSXMAP00000041243 ENSXMAP00000041243 Shq1 Shq1 ENSXMAP00000026730 ENSXMAP00000026730 nop10 nop10 blm blm terf1 terf1 rfc2 rfc2 rfc4 rfc4 ENSXMAP00000029005 ENSXMAP00000029005 ENSXMAP00000029079 ENSXMAP00000029079 ENSXMAP00000029359 ENSXMAP00000029359 ENSXMAP00000030751 ENSXMAP00000030751 ENSXMAP00000030905 ENSXMAP00000030905 ENSXMAP00000031223 ENSXMAP00000031223 rpa3 rpa3 dna2 dna2 ENSXMAP00000032345 ENSXMAP00000032345 LOC102223183 LOC102223183 LOC102222618 LOC102222618 LOC102235067 LOC102235067 terf2 terf2 prim1 prim1 terf2ip terf2ip tert tert pold2 pold2 recql4 recql4 pcna pcna trub1 trub1 rpa2 rpa2 ankrd28 ankrd28 LOC102230076 LOC102230076 pold4 pold4 LOC102227303 LOC102227303 wrap53 wrap53 LOC102233674 LOC102233674 ankrd52 ankrd52 meiob meiob pold1 pold1 RCBTB1 RCBTB1 dscc1 dscc1 stn1 stn1 RPA1 RPA1 M4A7C9_XIPMA M4A7C9_XIPMA M4A7C6_XIPMA M4A7C6_XIPMA pola2 pola2 rfc1 rfc1 prim2 prim2 Atrx Atrx ccna1 ccna1 H2AZ1 H2AZ1 chtf18 chtf18 rcbtb2 rcbtb2 LOC102237505 LOC102237505 nhp2 nhp2 LOC102232687 LOC102232687 chtf8 chtf8 fen1 fen1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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LOC102217251Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
ruvbl2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (459 aa)
lig1DNA ligase. (595 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1165 aa)
LOC102220076Zgc:110269. (347 aa)
LOC102237263ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (629 aa)
exd2Exonuclease 3'-5' domain containing 2. (639 aa)
LOC102224578ANK_REP_REGION domain-containing protein. (1043 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
PPP6CSerine/threonine-protein phosphatase. (305 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
gar1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (236 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (432 aa)
LOC102237630TERF1 (TRF1)-interacting nuclear factor 2. (486 aa)
HIST1H2BAHistone H2B; Belongs to the histone H2B family. (116 aa)
ENSXMAP00000020862Uncharacterized protein; Belongs to the histone H2A family. (245 aa)
ENSXMAP00000021083Histone H2A; Belongs to the histone H2A family. (133 aa)
ctc1Uncharacterized protein. (794 aa)
LOC111609624ATP-dependent DNA helicase; Belongs to the helicase family. (2786 aa)
ENSXMAP00000022343Histone H2A; Belongs to the histone H2A family. (137 aa)
pola1DNA polymerase. (1488 aa)
ENSXMAP00000023013Histone H2B; Belongs to the histone H2B family. (156 aa)
ENSXMAP00000023263Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
dkc1Dyskeratosis congenita 1, dyskerin. (498 aa)
rbpms2RNA binding protein, mRNA processing factor 2b. (220 aa)
ENSXMAP00000024331Histone H2B; Belongs to the histone H2B family. (111 aa)
ten1TEN1 subunit of CST complex. (132 aa)
LOC102230647ANK_REP_REGION domain-containing protein. (1057 aa)
ankrd44Ankyrin repeat domain 44. (1044 aa)
ENSXMAP00000025747Histone H2B; Belongs to the histone H2B family. (120 aa)
ENSXMAP00000025754ATP-dependent DNA helicase; Belongs to the helicase family. (2816 aa)
ENSXMAP00000025960Histone H2A; Belongs to the histone H2A family. (135 aa)
ENSXMAP00000026410ATP-dependent DNA helicase; Belongs to the helicase family. (2248 aa)
ENSXMAP00000026594Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSXMAP00000032360Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (158 aa)
ENSXMAP00000032554Histone H2B; Belongs to the histone H2B family. (112 aa)
ENSXMAP00000033462Histone H2B; Belongs to the histone H2B family. (158 aa)
ENSXMAP00000033576Histone H2A; Belongs to the histone H2A family. (141 aa)
LOC102230232RPA_C domain-containing protein. (247 aa)
LOC102237858Ankyrin repeat domain 66. (181 aa)
ENSXMAP00000035797annotation not available (2248 aa)
ENSXMAP00000036123Histone H2B; Belongs to the histone H2B family. (111 aa)
ENSXMAP00000036529Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSXMAP00000036593Histone H2A; Belongs to the histone H2A family. (139 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
pot1Telo_bind domain-containing protein. (889 aa)
ENSXMAP00000038433Zgc:171759; Belongs to the histone H2B family. (130 aa)
ENSXMAP00000038955Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (145 aa)
ENSXMAP00000040449Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
ENSXMAP00000041243Histone H2B; Belongs to the histone H2B family. (111 aa)
Shq1Uncharacterized protein. (48 aa)
ENSXMAP00000026730Histone H2B; Belongs to the histone H2B family. (150 aa)
nop10NOP10 ribonucleoprotein homolog (yeast). (64 aa)
blmBLM RecQ like helicase. (1398 aa)
terf1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (367 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
ENSXMAP00000029005Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa)
ENSXMAP00000029079annotation not available (95 aa)
ENSXMAP00000029359Histone H2B; Belongs to the histone H2B family. (115 aa)
ENSXMAP00000030751Histone H2A; Belongs to the histone H2A family. (139 aa)
ENSXMAP00000030905Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa)
ENSXMAP00000031223Histone H2A; Belongs to the histone H2A family. (122 aa)
rpa3Replication protein A3. (122 aa)
dna2Uncharacterized protein. (1324 aa)
ENSXMAP00000032345ATP-dependent DNA helicase; Belongs to the helicase family. (2302 aa)
LOC102223183Histone H2B; Belongs to the histone H2B family. (124 aa)
LOC102222618Histone H2A; Belongs to the histone H2A family. (138 aa)
LOC102235067Histone H2B; Belongs to the histone H2B family. (122 aa)
terf2HTH myb-type domain-containing protein. (626 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa)
terf2ipBRCT domain-containing protein. (705 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1097 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (528 aa)
recql4RecQ helicase-like 4. (1385 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
trub1TruB pseudouridine (psi) synthase family member 1. (277 aa)
rpa2Replication protein A2. (278 aa)
ankrd28Ankyrin repeat domain 28b. (1052 aa)
LOC102230076Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
pold4Si:dkey-28b4.7. (108 aa)
LOC102227303Serine/threonine-protein phosphatase. (305 aa)
wrap53WD repeat containing, antisense to TP53. (552 aa)
LOC102233674Uncharacterized protein. (1901 aa)
ankrd52Ankyrin repeat domain 52a. (1077 aa)
meiobMethionine sulfoxide reductase B1b. (425 aa)
pold1DNA polymerase. (1105 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
dscc1DNA replication and sister chromatid cohesion 1. (390 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (359 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (700 aa)
M4A7C9_XIPMAHistone H2B; Belongs to the histone H2B family. (134 aa)
M4A7C6_XIPMAHistone H2B; Belongs to the histone H2B family. (128 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa)
rfc1Replication factor C subunit 1. (1195 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (501 aa)
AtrxATRX chromatin remodeler. (1195 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (401 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (128 aa)
chtf18AAA domain-containing protein. (922 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
LOC102237505Death-domain associated protein. (723 aa)
nhp2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (156 aa)
LOC102232687Uncharacterized protein. (493 aa)
chtf8CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (133 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
Your Current Organism:
Xiphophorus maculatus
NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish
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