100 items (Xiphophorus maculatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102217254	Ribosomal protein S6 kinase. (783 aa)
	ENSXMAP00000041640	Si:dkey-23i12.7. (128 aa)
	LOC102223324	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (227 aa)
	creb1	Uncharacterized protein. (351 aa)
	LOC102218757	Uncharacterized protein. (286 aa)
	LOC102227723	Uncharacterized protein. (351 aa)
	LOC102216631	SHC (Src homology 2 domain containing) transforming protein 2. (717 aa)
	LOC102236106	Uncharacterized protein. (312 aa)
	LOC111608372	NTPase, KAP family P-loop domain containing 1. (716 aa)
	trib2	Tribbles pseudokinase 2. (344 aa)
	mapk15	Mitogen-activated protein kinase. (611 aa)
	mapkapk2	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily. (376 aa)
	dusp7	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
	frs2	Fibroblast growth factor receptor substrate 2b. (521 aa)
	LOC102229912	MADS-box domain-containing protein. (469 aa)
	nab2	NGFI-A binding protein 2 (EGR1 binding protein 2). (499 aa)
	LOC102232475	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family. (203 aa)
	LOC102233752	Mitogen-activated protein kinase. (435 aa)
	ENSXMAP00000033891	BZIP domain-containing protein. (90 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	LOC102227153	Insulin receptor substrate 2b. (1117 aa)
	elk1	ETS transcription factor ELK1. (527 aa)
	LOC102232228	V-ral simian leukemia viral oncogene homolog Ba (ras related). (207 aa)
	LOC102230176	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (406 aa)
	ENSXMAP00000032804	BZIP domain-containing protein. (108 aa)
	ENSXMAP00000032717	Protein kinase domain-containing protein. (97 aa)
	SGK1	Non-specific serine/threonine protein kinase. (612 aa)
	crkl	V-crk avian sarcoma virus CT10 oncogene homolog-like. (299 aa)
	sh3gl2	SH3 domain containing GRB2 like 2a, endophilin A1. (360 aa)
	egr3	Early growth response 3. (410 aa)
	dnal4	Dynein light chain. (106 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	ap2m1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (442 aa)
	map2k2	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
	LOC102237032	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (511 aa)
	SHC3	SHC adaptor protein 3. (668 aa)
	ppp4r4	Protein phosphatase 4, regulatory subunit 4. (908 aa)
	clta	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (232 aa)
	LOC102225341-2	KID domain-containing protein. (223 aa)
	hras	HRas proto-oncogene, GTPase a. (211 aa)
	LOC102221737	cAMP responsive element binding protein 1. (317 aa)
	ENSXMAP00000023898	SH3 domain-containing protein. (93 aa)
	LOC102219924	Kinase D-interacting substrate 220b. (1738 aa)
	Rapgef1	Ras-GEF domain-containing protein. (375 aa)
	LOC102223904	Inhibitor of DNA binding 4. (154 aa)
	LOC102237594	BHLH domain-containing protein. (458 aa)
	pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
	relch	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1189 aa)
	LOC102226410	V-ral simian leukemia viral oncogene homolog Aa (ras related). (206 aa)
	SRF	Serum response factor. (597 aa)
	LOC102231047	Mitogen-activated protein kinase. (360 aa)
	LOC102221788	ANK_REP_REGION domain-containing protein. (1651 aa)
	egr1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (512 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (907 aa)
	LOC102226157	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1152 aa)
	LOC102235637	Rap guanine nucleotide exchange factor (GEF) 1b. (1219 aa)
	LOC102232576	Nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain. (194 aa)
	JUND	BZIP domain-containing protein. (314 aa)
	M4AZP2_XIPMA	Achaete-scute family bHLH transcription factor 1b. (179 aa)
	ascl1	Achaete-scute family bHLH transcription factor 1a. (199 aa)
	LOC102237417	JunB proto-oncogene, AP-1 transcription factor subunit a. (330 aa)
	LOC111608373	NTPase, KAP family P-loop domain containing 1. (686 aa)
	fnbp4	Formin binding protein 4. (877 aa)
	LOC102235687	Ribosomal protein S6 kinase. (769 aa)
	LOC102234393	Inhibitor of DNA binding 3. (116 aa)
	DUSP3	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (219 aa)
	LOC102236340	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (366 aa)
	LOC102229921	Ribosomal protein S6 kinase. (775 aa)
	LOC102226863	Insulin receptor substrate 2a. (1061 aa)
	LOC102220269	Ribosomal protein S6 kinase. (794 aa)
	vrk3	VRK serine/threonine kinase 3. (527 aa)
	egr2	Early growth response 2b. (446 aa)
	mapk7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (1064 aa)
	LOC102225499	AP complex subunit beta. (953 aa)
	fosl1	FOS-like antigen 1a. (337 aa)
	LOC102232995	Zgc:55558. (187 aa)
	LOC102236567	Uncharacterized protein. (1780 aa)
	nab1	NGFI-A binding protein 1a (EGR1 binding protein 1). (508 aa)
	LOC102218102	Mitogen-activated protein kinase. (357 aa)
	ppp4r1	WRNPLPNID domain-containing protein. (970 aa)
	LOC102223674	Mitogen-activated protein kinase. (361 aa)
	LOC102223777	Serine/threonine-protein phosphatase. (309 aa)
	LOC102218230	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
	LOC102225341	cAMP responsive element modulator a. (111 aa)
	dusp6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (389 aa)
	LOC102225882	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ap2s1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
	ppp2r1b	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	LOC102222342	Tribbles pseudokinase 1. (361 aa)
	ralgds	Ral guanine nucleotide dissociation stimulator. (850 aa)
	LOC102229798	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (929 aa)
	crk	CRK proto-oncogene, adaptor protein. (306 aa)
	map2k5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (444 aa)
	LOC102216396	Activating transcription factor 1. (310 aa)
	MAPKAPK3	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (407 aa)
	LOC102227958	Chromodomain helicase DNA binding protein 4a. (1585 aa)
	LOC102231067	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (926 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	LOC102218230	ENSXMAP00000020890	ENSXMAP00000008625	Cold shock domain containing E1, RNA-binding.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.533
CSDE1	LOC102223777	ENSXMAP00000020890	ENSXMAP00000009409	Cold shock domain containing E1, RNA-binding.	Serine/threonine-protein phosphatase.	0.403
CSDE1	LOC102225882	ENSXMAP00000020890	ENSXMAP00000004675	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.533
CSDE1	LOC102226157	ENSXMAP00000020890	ENSXMAP00000020887	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.533
CSDE1	LOC102235637	ENSXMAP00000020890	ENSXMAP00000020736	Cold shock domain containing E1, RNA-binding.	Rap guanine nucleotide exchange factor (GEF) 1b.	0.409
CSDE1	LOC102237032	ENSXMAP00000020890	ENSXMAP00000028528	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.454
CSDE1	Rapgef1	ENSXMAP00000020890	ENSXMAP00000023499	Cold shock domain containing E1, RNA-binding.	Ras-GEF domain-containing protein.	0.409
CSDE1	SHC3	ENSXMAP00000020890	ENSXMAP00000028163	Cold shock domain containing E1, RNA-binding.	SHC adaptor protein 3.	0.419
CSDE1	frs2	ENSXMAP00000020890	ENSXMAP00000035416	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 2b.	0.448
CSDE1	map2k1	ENSXMAP00000020890	ENSXMAP00000003521	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.606
CSDE1	map2k2	ENSXMAP00000020890	ENSXMAP00000028918	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily.	0.606
CSDE1	map2k5	ENSXMAP00000020890	ENSXMAP00000002418	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.	0.606
CSDE1	mapk1	ENSXMAP00000020890	ENSXMAP00000006468	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.454
CSDE1	mapk7	ENSXMAP00000020890	ENSXMAP00000013808	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.454
CSDE1	pik3cb	ENSXMAP00000020890	ENSXMAP00000022787	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.533
CSDE1	ppp2ca	ENSXMAP00000020890	ENSXMAP00000008301	Cold shock domain containing E1, RNA-binding.	Serine/threonine-protein phosphatase.	0.403
CSDE1	ppp2cb	ENSXMAP00000020890	ENSXMAP00000031039	Cold shock domain containing E1, RNA-binding.	Serine/threonine-protein phosphatase.	0.403
CSDE1	ppp2r1b	ENSXMAP00000020890	ENSXMAP00000003881	Cold shock domain containing E1, RNA-binding.	Protein phosphatase 2, regulatory subunit A, beta b.	0.457
CSDE1	ralgds	ENSXMAP00000020890	ENSXMAP00000002803	Cold shock domain containing E1, RNA-binding.	Ral guanine nucleotide dissociation stimulator.	0.727
DUSP3	LOC102218102	ENSXMAP00000017930	ENSXMAP00000010371	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.780