(59 nodes) Downstream TCR signaling network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102226088	Component of inhibitor of nuclear factor kappa B kinase complex. (733 aa)
	LOC102217801	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (301 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
	pten	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (441 aa)
	LOC102226965	Uncharacterized protein. (464 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	card11	Caspase recruitment domain family, member 11. (1144 aa)
	LOC111611912	Ig_4 domain-containing protein. (164 aa)
	Cd3e	Ig_4 domain-containing protein. (191 aa)
	LOC102232287	Protein kinase domain-containing protein. (549 aa)
	M3ZL39_XIPMA	Ig_4 domain-containing protein. (171 aa)
	LOC102219298	MALT paracaspase 3. (565 aa)
	LOC102232994	MALT paracaspase 2. (819 aa)
	Uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (355 aa)
	LOC102225258	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	ikbkg	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (583 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (600 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (565 aa)
	map3k20	Uncharacterized protein. (796 aa)
	ENSXMAP00000020498	IGv domain-containing protein. (184 aa)
	ENSXMAP00000020797	Uncharacterized protein. (526 aa)
	ENSXMAP00000020837	DDE_Tnp_1_7 domain-containing protein. (468 aa)
	prkcq	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (719 aa)
	ENSXMAP00000023040	Ig-like domain-containing protein. (119 aa)
	ubb	Ubiquitin B. (838 aa)
	LOC111612149	DDE_Tnp_1_7 domain-containing protein. (621 aa)
	LOC111611233	DDE_Tnp_1_7 domain-containing protein. (649 aa)
	ENSXMAP00000025896	Ig-like domain-containing protein. (157 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (743 aa)
	ube2n	Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family. (184 aa)
	LOC102219047	MALT paracaspase 1. (828 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (447 aa)
	LOC111611568	DDE_Tnp_1_7 domain-containing protein. (696 aa)
	fbxw11	F-box and WD repeat domain containing 11a. (562 aa)
	ENSXMAP00000031293	Ig-like domain-containing protein. (146 aa)
	tab2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (740 aa)
	ENSXMAP00000032443	Uncharacterized protein. (137 aa)
	ENSXMAP00000034455	Ig-like domain-containing protein. (129 aa)
	ENSXMAP00000035919	Ig-like domain-containing protein. (126 aa)
	ENSXMAP00000036141	Ubiquitin-like domain-containing protein. (75 aa)
	ENSXMAP00000036823	Ig-like domain-containing protein. (255 aa)
	ENSXMAP00000037235	DDE_Tnp_1_7 domain-containing protein. (621 aa)
	ENSXMAP00000037365	Uncharacterized protein. (306 aa)
	ENSXMAP00000037658	Uncharacterized protein. (244 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (798 aa)
	ENSXMAP00000037974	Ig-like domain-containing protein. (304 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (584 aa)
	LOC102235544	Protein kinase domain-containing protein. (674 aa)
	ENSXMAP00000038873	Ig-like domain-containing protein. (101 aa)
	ENSXMAP00000039093	Ig-like domain-containing protein. (112 aa)
	ENSXMAP00000039484	Uncharacterized protein. (546 aa)
	ENSXMAP00000039720	Si:ch211-130m23.5. (677 aa)
	LOC111608418	DDE_Tnp_1_7 domain-containing protein. (719 aa)
	ENSXMAP00000041371	Ig-like domain-containing protein. (168 aa)
	ube2v1	Ubiquitin-conjugating enzyme E2 variant 1. (147 aa)
	inpp5d	Inositol polyphosphate-5-phosphatase D. (1083 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	M4A403_XIPMA	Uncharacterized protein. (237 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (386 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	ENSXMAP00000036141	ENSXMAP00000037970	ENSXMAP00000036141	Component of inhibitor of nuclear factor kappa B kinase complex.	Ubiquitin-like domain-containing protein.	0.562
CHUK	LOC102217801	ENSXMAP00000037970	ENSXMAP00000011794	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.963
CHUK	LOC102219047	ENSXMAP00000037970	ENSXMAP00000028354	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 1.	0.944
CHUK	LOC102219298	ENSXMAP00000037970	ENSXMAP00000002987	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 3.	0.469
CHUK	LOC102225258	ENSXMAP00000037970	ENSXMAP00000004065	Component of inhibitor of nuclear factor kappa B kinase complex.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.518
CHUK	LOC102226088	ENSXMAP00000037970	ENSXMAP00000010514	Component of inhibitor of nuclear factor kappa B kinase complex.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.943
CHUK	LOC102232287	ENSXMAP00000037970	ENSXMAP00000013789	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.965
CHUK	LOC102232994	ENSXMAP00000037970	ENSXMAP00000003498	Component of inhibitor of nuclear factor kappa B kinase complex.	MALT paracaspase 2.	0.944
CHUK	LOC102235544	ENSXMAP00000037970	ENSXMAP00000038321	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.642
CHUK	Uba52	ENSXMAP00000037970	ENSXMAP00000003931	Component of inhibitor of nuclear factor kappa B kinase complex.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.562
CHUK	card11	ENSXMAP00000037970	ENSXMAP00000001102	Component of inhibitor of nuclear factor kappa B kinase complex.	Caspase recruitment domain family, member 11.	0.641
CHUK	fbxw11	ENSXMAP00000037970	ENSXMAP00000031000	Component of inhibitor of nuclear factor kappa B kinase complex.	F-box and WD repeat domain containing 11a.	0.627
CHUK	ikbkb	ENSXMAP00000037970	ENSXMAP00000026035	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.951
CHUK	ikbkg	ENSXMAP00000037970	ENSXMAP00000004378	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.986
CHUK	map3k20	ENSXMAP00000037970	ENSXMAP00000005316	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.642
CHUK	map3k7	ENSXMAP00000037970	ENSXMAP00000005013	Component of inhibitor of nuclear factor kappa B kinase complex.	Mitogen-activated protein kinase kinase kinase 7.	0.962
CHUK	nfkbia	ENSXMAP00000037970	ENSXMAP00000009426	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.963
CHUK	pdpk1	ENSXMAP00000037970	ENSXMAP00000018949	Component of inhibitor of nuclear factor kappa B kinase complex.	3-phosphoinositide dependent protein kinase 1b.	0.950
CHUK	prkcq	ENSXMAP00000037970	ENSXMAP00000022331	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.931
CHUK	pten	ENSXMAP00000037970	ENSXMAP00000012984	Component of inhibitor of nuclear factor kappa B kinase complex.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.924