21 items (Xiphophorus maculatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cdkn2c	Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (162 aa)
	LOC102221782	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (217 aa)
	LOC102233635	Inhibitor of DNA binding 1, HLH protein. (127 aa)
	LOC102233304	Ets2 repressor factor. (519 aa)
	cdkn2d	Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
	cdk6	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (342 aa)
	ets1	V-ets avian erythroblastosis virus E26 oncogene homolog 1. (485 aa)
	LOC102237032	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (511 aa)
	ENSXMAP00000026894	Uncharacterized protein. (342 aa)
	LOC102232091	Ets2 repressor factor like 3. (762 aa)
	erfl	Ets2 repressor factor like 1. (471 aa)
	mdm4	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (490 aa)
	ubb	Ubiquitin B. (838 aa)
	LOC102229292	Ets variant 2. (444 aa)
	LOC102224522	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (203 aa)
	LOC102219250	Uncharacterized protein. (444 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
	cdkn2b	Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (124 aa)
	cdk4	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (316 aa)
	rps27a	Ribosomal protein S27a. (156 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSXMAP00000026894	LOC102237032	ENSXMAP00000026894	ENSXMAP00000028528	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.539
ENSXMAP00000026894	cdk4	ENSXMAP00000026894	ENSXMAP00000002447	Uncharacterized protein.	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.	0.636
ENSXMAP00000026894	cdk6	ENSXMAP00000026894	ENSXMAP00000031786	Uncharacterized protein.	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.	0.621
ENSXMAP00000026894	cdkn2b	ENSXMAP00000026894	ENSXMAP00000005450	Uncharacterized protein.	Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4).	0.761
ENSXMAP00000026894	mapk1	ENSXMAP00000026894	ENSXMAP00000006468	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.539
ENSXMAP00000026894	mdm4	ENSXMAP00000026894	ENSXMAP00000023343	Uncharacterized protein.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.971
ENSXMAP00000026894	rps27a	ENSXMAP00000026894	ENSXMAP00000000166	Uncharacterized protein.	Ribosomal protein S27a.	0.848
ENSXMAP00000026894	ubb	ENSXMAP00000026894	ENSXMAP00000023177	Uncharacterized protein.	Ubiquitin B.	0.678
LOC102219250	LOC102233635	ENSXMAP00000007756	ENSXMAP00000036800	Uncharacterized protein.	Inhibitor of DNA binding 1, HLH protein.	0.622
LOC102219250	LOC102237032	ENSXMAP00000007756	ENSXMAP00000028528	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.532
LOC102219250	mapk1	ENSXMAP00000007756	ENSXMAP00000006468	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.532
LOC102221782	LOC102237032	ENSXMAP00000040464	ENSXMAP00000028528	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.405
LOC102221782	mapk1	ENSXMAP00000040464	ENSXMAP00000006468	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.405
LOC102224522	LOC102237032	ENSXMAP00000010414	ENSXMAP00000028528	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.405
LOC102224522	mapk1	ENSXMAP00000010414	ENSXMAP00000006468	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.405
LOC102229292	LOC102233635	ENSXMAP00000017133	ENSXMAP00000036800	Ets variant 2.	Inhibitor of DNA binding 1, HLH protein.	0.622
LOC102229292	LOC102237032	ENSXMAP00000017133	ENSXMAP00000028528	Ets variant 2.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.532
LOC102229292	mapk1	ENSXMAP00000017133	ENSXMAP00000006468	Ets variant 2.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.532
LOC102233635	LOC102219250	ENSXMAP00000036800	ENSXMAP00000007756	Inhibitor of DNA binding 1, HLH protein.	Uncharacterized protein.	0.622
LOC102233635	LOC102229292	ENSXMAP00000036800	ENSXMAP00000017133	Inhibitor of DNA binding 1, HLH protein.	Ets variant 2.	0.622