STRINGSTRING
LOC102226183 LOC102226183 LOC102219367 LOC102219367 actb actb LOC102226519 LOC102226519 YES1 YES1 rock1 rock1 LOC102229798 LOC102229798 LOC102228495 LOC102228495 LOC102237893 LOC102237893 ap2s1 ap2s1 LOC102234903 LOC102234903 LOC102226142 LOC102226142 M3ZRB4_XIPMA M3ZRB4_XIPMA LOC102224211 LOC102224211 NCSTN NCSTN EFNA2 EFNA2 grin2b grin2b FMN1 FMN1 LOC102219379 LOC102219379 efna1 efna1 LOC102230691 LOC102230691 mmp2 mmp2 LOC111610977 LOC111610977 epha4 epha4 LOC102223554 LOC102223554 fndc3b fndc3b rock2 rock2 LOC102233390 LOC102233390 aph1a aph1a psen2 psen2 cltb cltb mmp9 mmp9 wasl wasl LOC102226407 LOC102226407 LOC102236058 LOC102236058 pak2 pak2 ephb6 ephb6 actr2 actr2 LOC102219831 LOC102219831 DNM1 DNM1 cfl1 cfl1 LOC102225499 LOC102225499 itsn1 itsn1 LOC102216726 LOC102216726 cltcl1 cltcl1 LOC102226889 LOC102226889 LOC102236272 LOC102236272 LOC102218394 LOC102218394 VAV1 VAV1 EFNA5 EFNA5 LOC102236830 LOC102236830 LOC102222452 LOC102222452 epha10 epha10 LOC111608325 LOC111608325 ephb2 ephb2 was was LOC102233157 LOC102233157 rasa1 rasa1 LOC102223132 LOC102223132 LOC102226201 LOC102226201 ENSXMAP00000022213 ENSXMAP00000022213 epha3 epha3 ephb4 ephb4 epha7 epha7 LOC102216434 LOC102216434 ENSXMAP00000023261 ENSXMAP00000023261 LOC102235277 LOC102235277 arpc4 arpc4 LOC102218296 LOC102218296 hras hras LOC102227392 LOC102227392 SRC SRC LOC102228105 LOC102228105 LOC102238061 LOC102238061 LOC102232517 LOC102232517 ephb3 ephb3 LOC102221449 LOC102221449 fndc3a fndc3a clta clta LOC102217912 LOC102217912 LOC102228761 LOC102228761 LOC102234854 LOC102234854 LOC102229675 LOC102229675 LOC102234981 LOC102234981 dnm1 dnm1 VAV3 VAV3 psenen psenen arpc3 arpc3 PAK3 PAK3 LOC102227147 LOC102227147 ap2m1 ap2m1 LOC102221167 LOC102221167 LOC102221882 LOC102221882 efna4 efna4 ENSXMAP00000030467 ENSXMAP00000030467 CDC42 CDC42 LOC102224517 LOC102224517 LOC102221843 LOC102221843 cfl2 cfl2 LOC102220646 LOC102220646 epha8 epha8 LOC102226130 LOC102226130 LOC102237794 LOC102237794 LOC102222129 LOC102222129 LOC102230269 LOC102230269 LOC102227197 LOC102227197 arpc2 arpc2 arpc5 arpc5 LOC102236308 LOC102236308 ENSXMAP00000038140 ENSXMAP00000038140 vav2 vav2 LOC102235952 LOC102235952 ACTR3 ACTR3 LOC102231931 LOC102231931 pak1 pak1 LOC102232342 LOC102232342 LOC102236014 LOC102236014 epha5 epha5 EPHA6 EPHA6
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102226183Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1685 aa)
LOC102219367Zgc:86896. (356 aa)
actbUncharacterized protein. (378 aa)
LOC102226519Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1677 aa)
YES1Tyrosine-protein kinase. (552 aa)
rock1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1380 aa)
LOC102229798AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (929 aa)
LOC102228495Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
LOC102237893FH2 domain-containing protein. (351 aa)
ap2s1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
LOC102234903Rho guanine nucleotide exchange factor (GEF) 7b. (849 aa)
LOC102226142Eph receptor B3a. (927 aa)
M3ZRB4_XIPMAGED domain-containing protein. (176 aa)
LOC102224211Uncharacterized protein; Belongs to the actin family. (424 aa)
NCSTNNicastrin. (701 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (216 aa)
grin2bUncharacterized protein. (1709 aa)
FMN1Formin 1. (1299 aa)
LOC102219379Rho guanine nucleotide exchange factor (GEF) 7a. (808 aa)
efna1Ephrin-A1b; Belongs to the ephrin family. (232 aa)
LOC102230691Eph receptor B4b. (1002 aa)
mmp2Matrix metallopeptidase 2. (657 aa)
LOC111610977Si:ch73-40a2.1. (876 aa)
epha4Eph receptor A4, like. (1026 aa)
LOC102223554Eph receptor B2a. (990 aa)
fndc3bFibronectin type III domain containing 3Ba. (1209 aa)
rock2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1377 aa)
LOC102233390Tyrosine-protein kinase. (537 aa)
aph1aAPH1B gamma secretase subunit. (258 aa)
psen2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (385 aa)
cltbClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (215 aa)
mmp9Matrix metallopeptidase 9. (689 aa)
waslWASP like actin nucleation promoting factor a. (482 aa)
LOC102226407Uncharacterized protein. (1028 aa)
LOC102236058Uncharacterized protein. (191 aa)
pak2Non-specific serine/threonine protein kinase. (526 aa)
ephb6Receptor protein-tyrosine kinase. (712 aa)
actr2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
LOC102219831Eph receptor A2 b. (991 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (641 aa)
cfl1Cofilin 1; Belongs to the actin-binding proteins ADF family. (211 aa)
LOC102225499AP complex subunit beta. (953 aa)
itsn1Intersectin 1 (SH3 domain protein). (1557 aa)
LOC102216726Zgc:101810; Belongs to the actin family. (394 aa)
cltcl1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1616 aa)
LOC102226889Ephrin-A1a; Belongs to the ephrin family. (222 aa)
LOC102236272Uncharacterized protein. (378 aa)
LOC102218394Uncharacterized protein. (375 aa)
VAV1Vav guanine nucleotide exchange factor 1. (844 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (224 aa)
LOC102236830Tyrosine-protein kinase. (544 aa)
LOC102222452Syndecan binding protein (syntenin) 2. (302 aa)
epha10Uncharacterized protein. (1021 aa)
LOC111608325Fibronectin type-III domain-containing protein. (588 aa)
ephb2Eph receptor B2b. (988 aa)
wasWASP actin nucleation promoting factor a. (530 aa)
LOC102233157Eph receptor A6. (952 aa)
rasa1RAS p21 protein activator (GTPase activating protein) 1a. (1049 aa)
LOC102223132Uncharacterized protein. (191 aa)
LOC102226201Eph receptor A2 a. (975 aa)
ENSXMAP00000022213Ephrin-A5a; Belongs to the ephrin family. (179 aa)
epha3Eph receptor A3. (994 aa)
ephb4Eph receptor B4a. (992 aa)
epha7Eph receptor A7. (1006 aa)
LOC102216434Ephrin-B1; Belongs to the ephrin family. (376 aa)
ENSXMAP00000023261Uncharacterized protein; Belongs to the actin family. (206 aa)
LOC102235277EPH receptor B1. (1007 aa)
arpc4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (180 aa)
LOC102218296Ephrin RBD domain-containing protein; Belongs to the ephrin family. (330 aa)
hrasHRas proto-oncogene, GTPase a. (211 aa)
LOC102227392ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (160 aa)
SRCTyrosine-protein kinase. (550 aa)
LOC102228105WH1 domain-containing protein. (366 aa)
LOC102238061T cell lymphoma invasion and metastasis 1a. (1672 aa)
LOC102232517Glutamate receptor, ionotropic, N-methyl D-aspartate 1b. (904 aa)
ephb3Uncharacterized protein. (985 aa)
LOC102221449Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (137 aa)
fndc3aFibronectin type III domain containing 3A. (1239 aa)
cltaClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (232 aa)
LOC102217912Eph receptor A4b. (1010 aa)
LOC102228761Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (399 aa)
LOC102234854T cell lymphoma invasion and metastasis 1b. (1595 aa)
LOC102229675Vav 3 guanine nucleotide exchange factor b. (862 aa)
LOC102234981Ephrin-A3b; Belongs to the ephrin family. (221 aa)
dnm1Dynamin 1a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (861 aa)
VAV3Vav guanine nucleotide exchange factor 3. (864 aa)
psenenPresenilin enhancer, gamma-secretase subunit. (101 aa)
arpc3Actin related protein 2/3 complex, subunit 3. (203 aa)
PAK3Non-specific serine/threonine protein kinase. (574 aa)
LOC102227147Ephrin-A3a; Belongs to the ephrin family. (224 aa)
ap2m1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (442 aa)
LOC102221167WASP like actin nucleation promoting factor b. (495 aa)
LOC102221882Ephrin-B3a; Belongs to the ephrin family. (338 aa)
efna4Ephrin RBD domain-containing protein; Belongs to the ephrin family. (200 aa)
ENSXMAP00000030467ANF_receptor domain-containing protein. (326 aa)
CDC42Cell division cycle 42. (191 aa)
LOC102224517Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (475 aa)
LOC102221843Formin 1. (1126 aa)
cfl2Cofilin 2 (muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
LOC102220646Glutamate receptor, ionotropic, N-methyl D-aspartate 1a. (964 aa)
epha8Uncharacterized protein. (1021 aa)
LOC102226130Cell division cycle 42. (191 aa)
LOC102237794Tyrosine-protein kinase. (537 aa)
LOC102222129Non-specific serine/threonine protein kinase. (507 aa)
LOC102230269Uncharacterized protein. (249 aa)
LOC102227197Tyrosine-protein kinase. (542 aa)
arpc2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (299 aa)
arpc5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (150 aa)
LOC102236308Uncharacterized protein. (1084 aa)
ENSXMAP00000038140Uncharacterized protein. (109 aa)
vav2Vav 2 guanine nucleotide exchange factor. (880 aa)
LOC102235952FH2 domain-containing protein. (1495 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (427 aa)
LOC102231931Ephrin-A2a; Belongs to the ephrin family. (207 aa)
pak1Non-specific serine/threonine protein kinase. (559 aa)
LOC102232342Ephrin-B2a; Belongs to the ephrin family. (335 aa)
LOC102236014Uncharacterized protein. (398 aa)
epha5Uncharacterized protein. (1013 aa)
EPHA6EPH receptor A6. (985 aa)
Your Current Organism:
Xiphophorus maculatus
NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish
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