38 items (Xiphophorus maculatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102233950	Uncharacterized protein. (858 aa)
	FGF6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	LOC102235496	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	LOC102237032	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (511 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1239 aa)
	LOC102231344	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (265 aa)
	SRC	Tyrosine-protein kinase. (550 aa)
	ubb	Ubiquitin B. (838 aa)
	LOC102235604	Sprouty RTK signaling antagonist 2. (349 aa)
	LOC102228479	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	mknk1	MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (462 aa)
	LOC102223777	Serine/threonine-protein phosphatase. (309 aa)
	fndc3b	Fibronectin type III domain containing 3Ba. (1209 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (953 aa)
	LOC102229665	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
	Uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (355 aa)
	ppp2r1b	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
	fgf1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (167 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	M3ZCY4_XIPMA	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (90 aa)
	LOC102237712	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (566 aa)
	LOC102227197	Tyrosine-protein kinase. (542 aa)
	fgf18	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	frs2	Fibroblast growth factor receptor substrate 2b. (521 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	LOC102237749	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (240 aa)
	mknk2	MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (475 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
	LOC102217141	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (158 aa)
	LOC102236879	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (177 aa)
	fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGF6	LOC102231344	ENSXMAP00000004295	ENSXMAP00000025395	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.532
FGF6	Uba52	ENSXMAP00000004295	ENSXMAP00000003931	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.409
FGF6	fgf19	ENSXMAP00000004295	ENSXMAP00000001516	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.508
FGF6	grb2	ENSXMAP00000004295	ENSXMAP00000004986	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Growth factor receptor-bound protein 2b.	0.455
FGF6	rps27a	ENSXMAP00000004295	ENSXMAP00000000166	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ribosomal protein S27a.	0.440
FGF6	ubb	ENSXMAP00000004295	ENSXMAP00000023177	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ubiquitin B.	0.430
FGF6-2	LOC102231344	ENSXMAP00000029267	ENSXMAP00000025395	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.532
FGF6-2	Uba52	ENSXMAP00000029267	ENSXMAP00000003931	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.409
FGF6-2	fgf19	ENSXMAP00000029267	ENSXMAP00000001516	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.512
FGF6-2	grb2	ENSXMAP00000029267	ENSXMAP00000004986	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Growth factor receptor-bound protein 2b.	0.455
FGF6-2	rps27a	ENSXMAP00000029267	ENSXMAP00000000166	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ribosomal protein S27a.	0.440
FGF6-2	ubb	ENSXMAP00000029267	ENSXMAP00000023177	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Ubiquitin B.	0.430
LOC102217141	LOC102229665	ENSXMAP00000032817	ENSXMAP00000029410	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.514
LOC102217141	LOC102231344	ENSXMAP00000032817	ENSXMAP00000025395	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.578
LOC102217141	LOC102233950	ENSXMAP00000032817	ENSXMAP00000008796	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Uncharacterized protein.	0.463
LOC102217141	LOC102236879	ENSXMAP00000032817	ENSXMAP00000032194	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.463
LOC102217141	LOC102237712	ENSXMAP00000032817	ENSXMAP00000037988	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Cbl proto-oncogene C, E3 ubiquitin protein ligase.	0.463
LOC102217141	LOC102237749	ENSXMAP00000032817	ENSXMAP00000033871	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.483
LOC102217141	M3ZCY4_XIPMA	ENSXMAP00000032817	ENSXMAP00000000076	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.418
LOC102217141	Uba52	ENSXMAP00000032817	ENSXMAP00000003931	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.473