51 items (Xiphophorus maculatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ppp2r1b	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
	M3ZCY4_XIPMA	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (90 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	fgf1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (167 aa)
	SHC4	SHC adaptor protein 4. (538 aa)
	Uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (355 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
	LOC102225882	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	LOC102218230	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	LOC102233950	Uncharacterized protein. (858 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (953 aa)
	fndc3b	Fibronectin type III domain containing 3Ba. (1209 aa)
	LOC102223777	Serine/threonine-protein phosphatase. (309 aa)
	LOC102218636	PH domain-containing protein. (763 aa)
	LOC102232995	Zgc:55558. (187 aa)
	mknk1	MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (462 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1306 aa)
	LOC102228479	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	LOC102226157	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1152 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (907 aa)
	LOC102235604	Sprouty RTK signaling antagonist 2. (349 aa)
	LOC102234385	Fibroblast growth factor receptor substrate 3. (610 aa)
	ubb	Ubiquitin B. (838 aa)
	hras	HRas proto-oncogene, GTPase a. (211 aa)
	SRC	Tyrosine-protein kinase. (550 aa)
	LOC102231344	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (265 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1239 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (456 aa)
	gab1	GRB2-associated binding protein 1. (765 aa)
	LOC102237032	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (511 aa)
	LOC102235496	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	FGF6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	LOC102229665	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
	LOC102236879	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (177 aa)
	LOC102217141	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (158 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
	mknk2	MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (475 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	LOC102237749	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (240 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	frs2	Fibroblast growth factor receptor substrate 2b. (521 aa)
	fgf18	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	LOC102227197	Tyrosine-protein kinase. (542 aa)
	LOC102237712	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (566 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	LOC102217141	ENSXMAP00000020890	ENSXMAP00000032817	Cold shock domain containing E1, RNA-binding.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.415
CSDE1	LOC102218230	ENSXMAP00000020890	ENSXMAP00000008625	Cold shock domain containing E1, RNA-binding.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.533
CSDE1	LOC102223777	ENSXMAP00000020890	ENSXMAP00000009409	Cold shock domain containing E1, RNA-binding.	Serine/threonine-protein phosphatase.	0.403
CSDE1	LOC102225882	ENSXMAP00000020890	ENSXMAP00000004675	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.533
CSDE1	LOC102226157	ENSXMAP00000020890	ENSXMAP00000020887	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.533
CSDE1	LOC102227197	ENSXMAP00000020890	ENSXMAP00000036131	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.423
CSDE1	LOC102229665	ENSXMAP00000020890	ENSXMAP00000029410	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.482
CSDE1	LOC102231344	ENSXMAP00000020890	ENSXMAP00000025395	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.434
CSDE1	LOC102234385	ENSXMAP00000020890	ENSXMAP00000021909	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 3.	0.448
CSDE1	LOC102237032	ENSXMAP00000020890	ENSXMAP00000028528	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.454
CSDE1	LOC102237749	ENSXMAP00000020890	ENSXMAP00000033871	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.445
CSDE1	SHC4	ENSXMAP00000020890	ENSXMAP00000002265	Cold shock domain containing E1, RNA-binding.	SHC adaptor protein 4.	0.419
CSDE1	SRC	ENSXMAP00000020890	ENSXMAP00000024894	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.423
CSDE1	Uba52	ENSXMAP00000020890	ENSXMAP00000003931	Cold shock domain containing E1, RNA-binding.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.492
CSDE1	fgf1	ENSXMAP00000020890	ENSXMAP00000001547	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.415
CSDE1	fgf17	ENSXMAP00000020890	ENSXMAP00000031692	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.448
CSDE1	fgf18	ENSXMAP00000020890	ENSXMAP00000036072	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.482
CSDE1	fgf19	ENSXMAP00000020890	ENSXMAP00000001516	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.420
CSDE1	frs2	ENSXMAP00000020890	ENSXMAP00000035416	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 2b.	0.448
CSDE1	grb2	ENSXMAP00000020890	ENSXMAP00000004986	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2b.	0.673