(25 nodes) Translesion synthesis by POLK network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	Uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (355 aa)
	polk	Polymerase (DNA directed) kappa. (935 aa)
	rcbtb2	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	rfc1	Replication factor C subunit 1. (1195 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (700 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	rev1	REV1 DNA directed polymerase. (1363 aa)
	meiob	Methionine sulfoxide reductase B1b. (425 aa)
	LOC102230076	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
	LOC102218031	ATPase family AAA domain containing 5a. (1810 aa)
	rpa2	Replication protein A2. (278 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	mad2l2	Mitotic arrest deficient 2 like 2. (210 aa)
	ubb	Ubiquitin B. (838 aa)
	rev3l	REV3 like, DNA directed polymerase zeta catalytic subunit. (3006 aa)
	rfc2	Replication factor C (activator 1) 2. (357 aa)
	rpa3	Replication protein A3. (122 aa)
	LOC102230232	RPA_C domain-containing protein. (247 aa)
	ENSXMAP00000036141	Ubiquitin-like domain-containing protein. (75 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSXMAP00000036141	LOC102230232	ENSXMAP00000036141	ENSXMAP00000035005	Ubiquitin-like domain-containing protein.	RPA_C domain-containing protein.	0.471
ENSXMAP00000036141	pcna	ENSXMAP00000036141	ENSXMAP00000014924	Ubiquitin-like domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.918
ENSXMAP00000036141	polk	ENSXMAP00000036141	ENSXMAP00000007045	Ubiquitin-like domain-containing protein.	Polymerase (DNA directed) kappa.	0.715
ENSXMAP00000036141	rev1	ENSXMAP00000036141	ENSXMAP00000011480	Ubiquitin-like domain-containing protein.	REV1 DNA directed polymerase.	0.847
ENSXMAP00000036141	rev3l	ENSXMAP00000036141	ENSXMAP00000025535	Ubiquitin-like domain-containing protein.	REV3 like, DNA directed polymerase zeta catalytic subunit.	0.587
ENSXMAP00000036141	rpa2	ENSXMAP00000036141	ENSXMAP00000014581	Ubiquitin-like domain-containing protein.	Replication protein A2.	0.471
ENSXMAP00000036141	rps27a	ENSXMAP00000036141	ENSXMAP00000000166	Ubiquitin-like domain-containing protein.	Ribosomal protein S27a.	0.994
ENSXMAP00000036141	ubb	ENSXMAP00000036141	ENSXMAP00000023177	Ubiquitin-like domain-containing protein.	Ubiquitin B.	0.964
LOC102218031	LOC102230232	ENSXMAP00000014316	ENSXMAP00000035005	ATPase family AAA domain containing 5a.	RPA_C domain-containing protein.	0.589
LOC102218031	RPA1	ENSXMAP00000014316	ENSXMAP00000010389	ATPase family AAA domain containing 5a.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.743
LOC102218031	mad2l2	ENSXMAP00000014316	ENSXMAP00000019434	ATPase family AAA domain containing 5a.	Mitotic arrest deficient 2 like 2.	0.687
LOC102218031	meiob	ENSXMAP00000014316	ENSXMAP00000011795	ATPase family AAA domain containing 5a.	Methionine sulfoxide reductase B1b.	0.743
LOC102218031	pcna	ENSXMAP00000014316	ENSXMAP00000014924	ATPase family AAA domain containing 5a.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.981
LOC102218031	polk	ENSXMAP00000014316	ENSXMAP00000007045	ATPase family AAA domain containing 5a.	Polymerase (DNA directed) kappa.	0.687
LOC102218031	rev1	ENSXMAP00000014316	ENSXMAP00000011480	ATPase family AAA domain containing 5a.	REV1 DNA directed polymerase.	0.701
LOC102218031	rev3l	ENSXMAP00000014316	ENSXMAP00000025535	ATPase family AAA domain containing 5a.	REV3 like, DNA directed polymerase zeta catalytic subunit.	0.800
LOC102218031	rfc1	ENSXMAP00000014316	ENSXMAP00000009604	ATPase family AAA domain containing 5a.	Replication factor C subunit 1.	0.672
LOC102218031	rfc2	ENSXMAP00000014316	ENSXMAP00000028736	ATPase family AAA domain containing 5a.	Replication factor C (activator 1) 2.	0.983
LOC102218031	rfc3	ENSXMAP00000014316	ENSXMAP00000040696	ATPase family AAA domain containing 5a.	Replication factor C (activator 1) 3.	0.988
LOC102218031	rfc4	ENSXMAP00000014316	ENSXMAP00000028805	ATPase family AAA domain containing 5a.	Replication factor C (activator 1) 4.	0.984