(156 nodes) Termination of translesion DNA synthesis network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rps27a	Ribosomal protein S27a. (156 aa)
	LOC102232412	Uncharacterized protein. (611 aa)
	LOC106699945	Uncharacterized protein. (608 aa)
	LOC102221863	Uncharacterized protein. (561 aa)
	LOC102226781	Uncharacterized protein. (560 aa)
	LOC111611027	Ig-like domain-containing protein. (193 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	LOC102224413	Uncharacterized protein. (510 aa)
	pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
	Uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (355 aa)
	LOC102224737	FinTRIM family, member 82. (573 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
	LOC102232957	Ubiquitin specific peptidase 43a; Belongs to the peptidase C19 family. (1227 aa)
	polk	Polymerase (DNA directed) kappa. (935 aa)
	rcbtb2	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2281 aa)
	M4A0S0_XIPMA	Tripartite motif containing 25, like. (547 aa)
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
	LOC102235173	Ubiquitin specific peptidase 43b; Belongs to the peptidase C19 family. (1187 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	rfc1	Replication factor C subunit 1. (1195 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (700 aa)
	polh	Polymerase (DNA directed), eta. (720 aa)
	M4A9Z7_XIPMA	Uncharacterized protein. (240 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	rev1	REV1 DNA directed polymerase. (1363 aa)
	pold1	DNA polymerase. (1105 aa)
	meiob	Methionine sulfoxide reductase B1b. (425 aa)
	LOC102217977	Uncharacterized protein. (483 aa)
	LOC102236185	Uncharacterized protein. (585 aa)
	pold4	Si:dkey-28b4.7. (108 aa)
	LOC102230076	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
	LOC102218031	ATPase family AAA domain containing 5a. (1810 aa)
	rpa2	Replication protein A2. (278 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (528 aa)
	LOC102231825	B30.2/SPRY domain-containing protein. (619 aa)
	LOC102220448	Uncharacterized protein. (567 aa)
	LOC102221238	Uncharacterized protein. (557 aa)
	LOC102218480	USP domain-containing protein; Belongs to the peptidase C19 family. (1299 aa)
	LOC111609519	Uncharacterized protein. (535 aa)
	M4AZM2_XIPMA	Uncharacterized protein. (365 aa)
	ENSXMAP00000020551	RING-type domain-containing protein. (105 aa)
	ENSXMAP00000020561	Uncharacterized protein. (451 aa)
	LOC102229516	Uncharacterized protein. (571 aa)
	LOC102217907	Uncharacterized protein. (550 aa)
	LOC102218336	Uncharacterized protein. (564 aa)
	ENSXMAP00000021401	Uncharacterized protein. (250 aa)
	ENSXMAP00000021703	Uncharacterized protein. (293 aa)
	LOC106700056	B30.2/SPRY domain-containing protein. (342 aa)
	LOC102231954	SCY domain-containing protein. (144 aa)
	LOC111608441	Uncharacterized protein. (548 aa)
	ENSXMAP00000022284	Uncharacterized protein. (557 aa)
	LOC111608863	Uncharacterized protein. (568 aa)
	ENSXMAP00000022650	Uncharacterized protein. (273 aa)
	ENSXMAP00000022937	RING-type domain-containing protein. (149 aa)
	ENSXMAP00000023039	Uncharacterized protein. (554 aa)
	ubb	Ubiquitin B. (838 aa)
	LOC111606267	Uncharacterized protein. (522 aa)
	ENSXMAP00000023797	Uncharacterized protein. (234 aa)
	LOC102223960	Uncharacterized protein. (543 aa)
	ENSXMAP00000024034	Uncharacterized protein. (394 aa)
	poli	Polymerase (DNA directed) iota. (708 aa)
	ENSXMAP00000025520	Uncharacterized protein. (494 aa)
	LOC102220187	B30.2/SPRY domain-containing protein. (460 aa)
	LOC102230521	Uncharacterized protein. (571 aa)
	LOC102217977-2	Uncharacterized protein. (534 aa)
	LOC102220057	Uncharacterized protein. (555 aa)
	ENSXMAP00000026336	Uncharacterized protein. (231 aa)
	ENSXMAP00000026370	Uncharacterized protein. (557 aa)
	LOC102218306	B30.2/SPRY domain-containing protein. (1278 aa)
	ENSXMAP00000027110	RING-type domain-containing protein. (129 aa)
	LOC111611848	Uncharacterized protein. (314 aa)
	LOC111607860	Uncharacterized protein. (274 aa)
	ENSXMAP00000027877	Uncharacterized protein. (536 aa)
	ENSXMAP00000028029	Uncharacterized protein. (239 aa)
	ENSXMAP00000028192	Uncharacterized protein. (242 aa)
	ENSXMAP00000028199	Uncharacterized protein. (370 aa)
	LOC106700390	Uncharacterized protein. (556 aa)
	ENSXMAP00000028337	Uncharacterized protein. (314 aa)
	LOC102220972	Uncharacterized protein. (545 aa)
	ENSXMAP00000028603	B30.2/SPRY domain-containing protein. (277 aa)
	ENSXMAP00000028613	Uncharacterized protein. (556 aa)
	rfc2	Replication factor C (activator 1) 2. (357 aa)
	usp31	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family. (1289 aa)
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	LOC111606267-2	Uncharacterized protein. (555 aa)
	LOC102221756	Bloodthirsty-related gene family, member 12. (564 aa)
	ENSXMAP00000029595	Uncharacterized protein. (274 aa)
	LOC111611196	Ig-like domain-containing protein. (267 aa)
	ENSXMAP00000029918	B30.2/SPRY domain-containing protein. (192 aa)
	ENSXMAP00000029939	B30.2/SPRY domain-containing protein. (221 aa)
	vbp1	Uncharacterized protein. (541 aa)
	ENSXMAP00000030279	Uncharacterized protein. (213 aa)
	ENSXMAP00000030320	Uncharacterized protein. (470 aa)
	LOC111608475	Uncharacterized protein. (548 aa)
	ENSXMAP00000030750	Uncharacterized protein. (551 aa)
	ENSXMAP00000030852	RING-type domain-containing protein. (76 aa)
	LOC106700460	Uncharacterized protein. (559 aa)
	ENSXMAP00000031213	Uncharacterized protein. (556 aa)
	LOC102223890	Uncharacterized protein. (547 aa)
	ENSXMAP00000031238	Uncharacterized protein. (246 aa)
	LOC102232411	Uncharacterized protein. (555 aa)
	LOC102234656	Uncharacterized protein. (553 aa)
	rpa3	Replication protein A3. (122 aa)
	LOC102231564	Uncharacterized protein. (446 aa)
	pclaf	PCNA clamp associated factor. (117 aa)
	ENSXMAP00000032174	Uncharacterized protein. (462 aa)
	ENSXMAP00000032193	RING-type domain-containing protein. (81 aa)
	LOC111606268	Uncharacterized protein. (474 aa)
	ENSXMAP00000032800	B30.2/SPRY domain-containing protein. (194 aa)
	LOC102216995	Uncharacterized protein. (560 aa)
	ENSXMAP00000033617	Si:dkey-46i9.6. (189 aa)
	ENSXMAP00000033991	Uncharacterized protein. (400 aa)
	ENSXMAP00000034181	Uncharacterized protein. (385 aa)
	ENSXMAP00000034294	Uncharacterized protein. (508 aa)
	ENSXMAP00000034828	Uncharacterized protein. (228 aa)
	ENSXMAP00000034838	Uncharacterized protein. (335 aa)
	LOC102228326	Uncharacterized protein. (253 aa)
	LOC102230232	RPA_C domain-containing protein. (247 aa)
	ENSXMAP00000035045	Uncharacterized protein. (541 aa)
	ENSXMAP00000035270	Uncharacterized protein. (551 aa)
	ENSXMAP00000035359	Uncharacterized protein. (512 aa)
	ENSXMAP00000035706	Uncharacterized protein. (560 aa)
	usp10	Ubiquitin carboxyl-terminal hydrolase. (877 aa)
	ENSXMAP00000036141	Ubiquitin-like domain-containing protein. (75 aa)
	ENSXMAP00000036264	Uncharacterized protein. (280 aa)
	ENSXMAP00000036314	Uncharacterized protein. (256 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
	ENSXMAP00000036834	B30.2/SPRY domain-containing protein. (235 aa)
	ENSXMAP00000036859	RING-type domain-containing protein. (442 aa)
	ENSXMAP00000036950	Uncharacterized protein. (310 aa)
	ENSXMAP00000037262	Uncharacterized protein. (549 aa)
	ENSXMAP00000037270	Uncharacterized protein. (242 aa)
	pole3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
	LOC106700455	Uncharacterized protein. (552 aa)
	ENSXMAP00000037746	Uncharacterized protein. (228 aa)
	ENSXMAP00000037971	Uncharacterized protein. (556 aa)
	ENSXMAP00000038016	RING-type domain-containing protein. (90 aa)
	LOC111609383	Uncharacterized protein. (509 aa)
	ENSXMAP00000038325	Uncharacterized protein. (565 aa)
	ENSXMAP00000038463	B30.2/SPRY domain-containing protein. (240 aa)
	ENSXMAP00000038602	Uncharacterized protein. (202 aa)
	LOC102234324	Uncharacterized protein. (595 aa)
	ENSXMAP00000039124	Uncharacterized protein. (557 aa)
	ENSXMAP00000039125	Uncharacterized protein. (558 aa)
	ENSXMAP00000039167	RING-type domain-containing protein. (87 aa)
	ENSXMAP00000040131	B30.2/SPRY domain-containing protein. (192 aa)
	ENSXMAP00000040345	Uncharacterized protein. (421 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	ENSXMAP00000040782	Uncharacterized protein. (356 aa)
	ENSXMAP00000040917	Uncharacterized protein. (559 aa)
	LOC102229992	Uncharacterized protein. (554 aa)
	LOC102236228	Uncharacterized protein. (556 aa)
	ENSXMAP00000041412	Uncharacterized protein. (259 aa)
	ENSXMAP00000041467	RING-type domain-containing protein. (453 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSXMAP00000036141	LOC102218480	ENSXMAP00000036141	ENSXMAP00000019042	Ubiquitin-like domain-containing protein.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.431
ENSXMAP00000036141	LOC102230232	ENSXMAP00000036141	ENSXMAP00000035005	Ubiquitin-like domain-containing protein.	RPA_C domain-containing protein.	0.471
ENSXMAP00000036141	LOC102232957	ENSXMAP00000036141	ENSXMAP00000006654	Ubiquitin-like domain-containing protein.	Ubiquitin specific peptidase 43a; Belongs to the peptidase C19 family.	0.431
ENSXMAP00000036141	LOC102235173	ENSXMAP00000036141	ENSXMAP00000008378	Ubiquitin-like domain-containing protein.	Ubiquitin specific peptidase 43b; Belongs to the peptidase C19 family.	0.431
ENSXMAP00000036141	pclaf	ENSXMAP00000036141	ENSXMAP00000032017	Ubiquitin-like domain-containing protein.	PCNA clamp associated factor.	0.589
ENSXMAP00000036141	pcna	ENSXMAP00000036141	ENSXMAP00000014924	Ubiquitin-like domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.918
ENSXMAP00000036141	pold1	ENSXMAP00000036141	ENSXMAP00000011793	Ubiquitin-like domain-containing protein.	DNA polymerase.	0.595
ENSXMAP00000036141	pole	ENSXMAP00000036141	ENSXMAP00000007836	Ubiquitin-like domain-containing protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.596
ENSXMAP00000036141	polh	ENSXMAP00000036141	ENSXMAP00000010617	Ubiquitin-like domain-containing protein.	Polymerase (DNA directed), eta.	0.778
ENSXMAP00000036141	poli	ENSXMAP00000036141	ENSXMAP00000024273	Ubiquitin-like domain-containing protein.	Polymerase (DNA directed) iota.	0.846
ENSXMAP00000036141	polk	ENSXMAP00000036141	ENSXMAP00000007045	Ubiquitin-like domain-containing protein.	Polymerase (DNA directed) kappa.	0.715
ENSXMAP00000036141	rev1	ENSXMAP00000036141	ENSXMAP00000011480	Ubiquitin-like domain-containing protein.	REV1 DNA directed polymerase.	0.847
ENSXMAP00000036141	rpa2	ENSXMAP00000036141	ENSXMAP00000014581	Ubiquitin-like domain-containing protein.	Replication protein A2.	0.471
ENSXMAP00000036141	rps27a	ENSXMAP00000036141	ENSXMAP00000000166	Ubiquitin-like domain-containing protein.	Ribosomal protein S27a.	0.994
ENSXMAP00000036141	ubb	ENSXMAP00000036141	ENSXMAP00000023177	Ubiquitin-like domain-containing protein.	Ubiquitin B.	0.964
ENSXMAP00000036141	usp10	ENSXMAP00000036141	ENSXMAP00000036091	Ubiquitin-like domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase.	0.527
ENSXMAP00000036141	usp31	ENSXMAP00000036141	ENSXMAP00000028765	Ubiquitin-like domain-containing protein.	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family.	0.431
LOC102218031	LOC102230232	ENSXMAP00000014316	ENSXMAP00000035005	ATPase family AAA domain containing 5a.	RPA_C domain-containing protein.	0.589
LOC102218031	LOC102231954	ENSXMAP00000014316	ENSXMAP00000022037	ATPase family AAA domain containing 5a.	SCY domain-containing protein.	0.673
LOC102218031	RPA1	ENSXMAP00000014316	ENSXMAP00000010389	ATPase family AAA domain containing 5a.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.743