(43 nodes) Regulation of TP53 Degradation network (Xiphophorus maculatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (325 aa)
	akt2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	txndc11	Thioredoxin domain containing 11. (847 aa)
	LOC102217371	Ubiquitin carboxyl-terminal hydrolase. (399 aa)
	LOC102223777	Serine/threonine-protein phosphatase. (309 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	ccna1	Cyclin A1; Belongs to the cyclin family. (401 aa)
	LOC102221251	Ring finger protein 34b. (402 aa)
	ENSXMAP00000026894	Uncharacterized protein. (342 aa)
	phf20	PHD finger protein 20, a. (998 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	LOC102237505	Death-domain associated protein. (723 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	mdm2	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family. (468 aa)
	Uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (355 aa)
	ppp2r1b	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
	LOC102224028	Uncharacterized protein. (471 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	ccna2	Cyclin A2; Belongs to the cyclin family. (432 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (342 aa)
	mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae). (326 aa)
	LOC102232504	Non-specific serine/threonine protein kinase. (503 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	ENSXMAP00000031253	Uncharacterized protein. (75 aa)
	SGK1	Non-specific serine/threonine protein kinase. (612 aa)
	ENSXMAP00000032717	Protein kinase domain-containing protein. (97 aa)
	LOC102237954	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	ENSXMAP00000036141	Ubiquitin-like domain-containing protein. (75 aa)
	ENSXMAP00000038474	Uncharacterized protein. (100 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1185 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1011 aa)
	LOC102224037	Checkpoint kinase 2. (442 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	mapkap1	MAPK associated protein 1. (525 aa)
	atm	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2875 aa)
	rffl	Ring finger and FYVE-like domain containing E3 ubiquitin protein ligase. (340 aa)
	rictor	RPTOR independent companion of MTOR, complex 2 a. (1724 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (565 aa)
	ubb	Ubiquitin B. (838 aa)
	mdm4	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (490 aa)
	ccng1	Cyclin G1; Belongs to the cyclin family. (297 aa)
	LOC102230709	Ubiquitin carboxyl-terminal hydrolase. (593 aa)
	LOC102227808	Ring finger protein 34a. (381 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSXMAP00000026894	ENSXMAP00000031253	ENSXMAP00000026894	ENSXMAP00000031253	Uncharacterized protein.	Uncharacterized protein.	0.588
ENSXMAP00000026894	ENSXMAP00000036141	ENSXMAP00000026894	ENSXMAP00000036141	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.430
ENSXMAP00000026894	ENSXMAP00000038474	ENSXMAP00000026894	ENSXMAP00000038474	Uncharacterized protein.	Uncharacterized protein.	0.588
ENSXMAP00000026894	LOC102224037	ENSXMAP00000026894	ENSXMAP00000001234	Uncharacterized protein.	Checkpoint kinase 2.	0.908
ENSXMAP00000026894	LOC102237505	ENSXMAP00000026894	ENSXMAP00000007103	Uncharacterized protein.	Death-domain associated protein.	0.824
ENSXMAP00000026894	Mtor	ENSXMAP00000026894	ENSXMAP00000001362	Uncharacterized protein.	Serine/threonine-protein kinase TOR.	0.487
ENSXMAP00000026894	Uba52	ENSXMAP00000026894	ENSXMAP00000003931	Uncharacterized protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.430
ENSXMAP00000026894	atm	ENSXMAP00000026894	ENSXMAP00000016978	Uncharacterized protein.	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.951
ENSXMAP00000026894	ccna1	ENSXMAP00000026894	ENSXMAP00000008580	Uncharacterized protein.	Cyclin A1; Belongs to the cyclin family.	0.618
ENSXMAP00000026894	ccna2	ENSXMAP00000026894	ENSXMAP00000002060	Uncharacterized protein.	Cyclin A2; Belongs to the cyclin family.	0.622
ENSXMAP00000026894	ccng1	ENSXMAP00000026894	ENSXMAP00000025092	Uncharacterized protein.	Cyclin G1; Belongs to the cyclin family.	0.756
ENSXMAP00000026894	cdk1	ENSXMAP00000026894	ENSXMAP00000014767	Uncharacterized protein.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.621
ENSXMAP00000026894	cdk2	ENSXMAP00000026894	ENSXMAP00000003340	Uncharacterized protein.	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	0.664
ENSXMAP00000026894	mdm2	ENSXMAP00000026894	ENSXMAP00000028716	Uncharacterized protein.	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family.	0.972
ENSXMAP00000026894	mdm4	ENSXMAP00000026894	ENSXMAP00000023343	Uncharacterized protein.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.971
ENSXMAP00000026894	phf20	ENSXMAP00000026894	ENSXMAP00000028247	Uncharacterized protein.	PHD finger protein 20, a.	0.588
ENSXMAP00000026894	ppp2r1b	ENSXMAP00000026894	ENSXMAP00000003881	Uncharacterized protein.	Protein phosphatase 2, regulatory subunit A, beta b.	0.449
ENSXMAP00000026894	rps27a	ENSXMAP00000026894	ENSXMAP00000000166	Uncharacterized protein.	Ribosomal protein S27a.	0.848
ENSXMAP00000026894	ubb	ENSXMAP00000026894	ENSXMAP00000023177	Uncharacterized protein.	Ubiquitin B.	0.678
ENSXMAP00000026894	usp7	ENSXMAP00000026894	ENSXMAP00000001659	Uncharacterized protein.	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family.	0.950