(67 nodes) Platelet Aggregation (Plug Formation) network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	crk	CRK proto-oncogene, adaptor protein. (306 aa)
	LOC111611705	Si:ch211-237i5.4. (359 aa)
	LOC102219024	Tyrosine-protein kinase. (447 aa)
	LOC102223180	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1a. (1453 aa)
	LOC102237373	Embryonal Fyn-associated substrate. (967 aa)
	LOC102229118	LRRNT domain-containing protein. (668 aa)
	rapgefl1	Rap guanine nucleotide exchange factor (GEF)-like 1. (682 aa)
	f2	Coagulation factor II (thrombin); Belongs to the peptidase S1 family. (614 aa)
	LOC102218757	Uncharacterized protein. (286 aa)
	LOC106700229	LRRCT domain-containing protein. (712 aa)
	ENSXMAP00000038902	Fibrinogen C-terminal domain-containing protein. (253 aa)
	LOC102235481	Si:ch211-38m6.6. (437 aa)
	LOC102227197	Tyrosine-protein kinase. (542 aa)
	LOC102237954	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	itgb3	Integrin beta; Belongs to the integrin beta chain family. (792 aa)
	nedd9	Neural precursor cell expressed, developmentally down-regulated 9. (789 aa)
	LOC102221802	Integrin beta; Belongs to the integrin beta chain family. (791 aa)
	ENSXMAP00000032844	FERM domain-containing protein. (306 aa)
	RASGRP2	RAS guanyl releasing protein 2. (598 aa)
	LOC102232504	Non-specific serine/threonine protein kinase. (503 aa)
	LOC111609941	Uncharacterized protein. (448 aa)
	rapgef4	Rap guanine nucleotide exchange factor (GEF) 4. (1020 aa)
	bcar1	BCAR1 scaffold protein, Cas family member. (967 aa)
	col1a1	Collagen, type I, alpha 1a. (1364 aa)
	LOC102226994	Uncharacterized protein. (185 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (456 aa)
	LOC102222768	Rap guanine nucleotide exchange factor (GEF) 3. (868 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1239 aa)
	SRC	Tyrosine-protein kinase. (550 aa)
	ENSXMAP00000024788	Adrenoceptor alpha 2C. (418 aa)
	syk	Tyrosine-protein kinase. (627 aa)
	LOC102230342	Adrenoceptor alpha 2B; Belongs to the G-protein coupled receptor 1 family. (523 aa)
	gp1bb	Glycoprotein Ib platelet subunit beta. (206 aa)
	LOC102219330	Adrenoceptor alpha 2A. (435 aa)
	ADRA2C	Adrenoceptor alpha 2C. (429 aa)
	LOC102229866	G_PROTEIN_RECEP_F1_2 domain-containing protein. (399 aa)
	tlnrd1	Talin rod domain containing 1. (354 aa)
	LOC102217330	Zgc:171558. (912 aa)
	fgg	Fibrinogen gamma chain. (432 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (565 aa)
	LOC102236702	Glycoprotein IX (platelet). (257 aa)
	LOC102236583	Reticulon 4 receptor-like 2 a. (455 aa)
	LOC102229978	Collagen, type I, alpha 1b. (1323 aa)
	LOC102218259	Talin 2a. (2541 aa)
	CSK	Tyrosine-protein kinase. (451 aa)
	RAPGEF5	Uncharacterized protein. (539 aa)
	cass4	Cas scaffold protein family member 4. (852 aa)
	mfsd8	Major facilitator superfamily domain containing 8. (503 aa)
	LOC102234542	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1b. (1344 aa)
	LOC102218352	Tyrosine-protein phosphatase non-receptor type. (422 aa)
	mpl	MPL proto-oncogene, thrombopoietin receptor. (630 aa)
	LOC102233612	Reticulon 4 receptor-like 2b. (460 aa)
	fndc3b	Fibronectin type III domain containing 3Ba. (1209 aa)
	apbb1ip	Amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein. (683 aa)
	fgb	Fibrinogen beta chain. (495 aa)
	Fga	Fibrinogen alpha chain. (731 aa)
	tln1	Talin 1. (2215 aa)
	LOC102228243	Uncharacterized protein. (421 aa)
	LOC102223832	Uncharacterized protein. (184 aa)
	LOC102235995	RAP1A, member of RAS oncogene family b. (185 aa)
	LOC106699661	MFS domain-containing protein. (540 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	tln2	Talin 2b. (2504 aa)
	SHC4	SHC adaptor protein 4. (538 aa)
	LOC102230011	Fibronectin 1a. (2488 aa)
	col1a2	Collagen, type I, alpha 2. (1354 aa)
	LOC102216758	Rap guanine nucleotide exchange factor (GEF) 5a. (919 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSK	ENSXMAP00000032844	ENSXMAP00000016789	ENSXMAP00000032844	Tyrosine-protein kinase.	FERM domain-containing protein.	0.442
CSK	LOC102218259	ENSXMAP00000016789	ENSXMAP00000017374	Tyrosine-protein kinase.	Talin 2a.	0.442
CSK	LOC102218352	ENSXMAP00000016789	ENSXMAP00000011581	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type.	0.424
CSK	LOC102218757	ENSXMAP00000016789	ENSXMAP00000039060	Tyrosine-protein kinase.	Uncharacterized protein.	0.471
CSK	LOC102223180	ENSXMAP00000016789	ENSXMAP00000040269	Tyrosine-protein kinase.	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1a.	0.455
CSK	LOC102223832	ENSXMAP00000016789	ENSXMAP00000006551	Tyrosine-protein kinase.	Uncharacterized protein.	0.477
CSK	LOC102226994	ENSXMAP00000016789	ENSXMAP00000026714	Tyrosine-protein kinase.	Uncharacterized protein.	0.477
CSK	LOC102227197	ENSXMAP00000016789	ENSXMAP00000036131	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.704
CSK	LOC102228243	ENSXMAP00000016789	ENSXMAP00000006870	Tyrosine-protein kinase.	Uncharacterized protein.	0.455
CSK	LOC102234542	ENSXMAP00000016789	ENSXMAP00000012494	Tyrosine-protein kinase.	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1b.	0.455
CSK	LOC102235995	ENSXMAP00000016789	ENSXMAP00000006006	Tyrosine-protein kinase.	RAP1A, member of RAS oncogene family b.	0.477
CSK	LOC102237373	ENSXMAP00000016789	ENSXMAP00000039751	Tyrosine-protein kinase.	Embryonal Fyn-associated substrate.	0.527
CSK	SHC4	ENSXMAP00000016789	ENSXMAP00000002265	Tyrosine-protein kinase.	SHC adaptor protein 4.	0.604
CSK	SRC	ENSXMAP00000016789	ENSXMAP00000024894	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.704
CSK	apbb1ip	ENSXMAP00000016789	ENSXMAP00000008337	Tyrosine-protein kinase.	Amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein.	0.455
CSK	bcar1	ENSXMAP00000016789	ENSXMAP00000027717	Tyrosine-protein kinase.	BCAR1 scaffold protein, Cas family member.	0.532
CSK	cass4	ENSXMAP00000016789	ENSXMAP00000014031	Tyrosine-protein kinase.	Cas scaffold protein family member 4.	0.532
CSK	crk	ENSXMAP00000016789	ENSXMAP00000002446	Tyrosine-protein kinase.	CRK proto-oncogene, adaptor protein.	0.471
CSK	grb2	ENSXMAP00000016789	ENSXMAP00000004986	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2b.	0.624
CSK	nedd9	ENSXMAP00000016789	ENSXMAP00000033818	Tyrosine-protein kinase.	Neural precursor cell expressed, developmentally down-regulated 9.	0.532