(72 nodes) Signaling by PTK6 network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sfpq	Splicing factor proline/glutamine-rich. (675 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	ccne1	Cyclin E1; Belongs to the cyclin family. (434 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	erbb3	Protein kinase domain-containing protein. (1413 aa)
	LOC102232069	Engulfment and cell motility 3. (715 aa)
	M3ZJA3_XIPMA	Epidermal growth factor. (946 aa)
	crk	CRK proto-oncogene, adaptor protein. (306 aa)
	cdk4	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (316 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	Uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (355 aa)
	KHDRBS3	KH RNA binding domain containing, signal transduction associated 3. (336 aa)
	LOC102223400	KH domain containing, RNA binding, signal transduction associated 1a. (371 aa)
	LOC102220797	Uncharacterized protein. (1139 aa)
	LOC102233271	Paraspeckle component 1. (423 aa)
	LOC102233950	Uncharacterized protein. (858 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (953 aa)
	LOC102228937	Melanoma receptor tyrosine-protein kinase; Probable receptor with tyrosine-protein kinase activity. (1167 aa)
	M4A2Z4_XIPMA	Receptor protein-tyrosine kinase. (1155 aa)
	LOC102221813	Docking protein 1b. (656 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	ptk6	Tyrosine-protein kinase. (500 aa)
	khdrbs2	KH domain containing, RNA binding, signal transduction associated 2. (342 aa)
	LOC102235773	Cyclin-dependent kinase inhibitor 1Bb. (194 aa)
	elmod2	ELMO/CED-12 domain containing 2. (297 aa)
	hbegf	Heparin-binding EGF-like growth factor. (236 aa)
	LOC102218352	Tyrosine-protein phosphatase non-receptor type. (422 aa)
	LOC102232995	Zgc:55558. (187 aa)
	LOC102220912	Crystallin, beta B1, like 3; Belongs to the beta/gamma-crystallin family. (254 aa)
	LOC102225731	Rho GTPase activating protein 35b. (1529 aa)
	LOC102226880	Signal transducing adaptor family member 2b. (391 aa)
	M4ADI1_XIPMA	Suppressor of cytokine signaling 3a. (251 aa)
	lpxn	Leupaxin. (428 aa)
	LOC102231767	Receptor protein-tyrosine kinase. (1376 aa)
	LOC102236062	Receptor protein-tyrosine kinase. (1209 aa)
	TGFB1I1	Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (480 aa)
	LOC102220670	Signal transducing adaptor family member 2a. (376 aa)
	rasa1	RAS p21 protein activator (GTPase activating protein) 1a. (1049 aa)
	rnf222	RING-type domain-containing protein. (208 aa)
	nono	Non-POU domain containing, octamer-binding. (439 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (907 aa)
	LOC102218549	Neuregulin 2a. (731 aa)
	elmo2	Engulfment and cell motility 2. (721 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2328 aa)
	LOC102237725	Uncharacterized protein. (773 aa)
	ubb	Ubiquitin B. (838 aa)
	elmod1	ELMO/CED-12 domain containing 1. (394 aa)
	hras	HRas proto-oncogene, GTPase a. (211 aa)
	elmo1	Engulfment and cell motility 1. (740 aa)
	erbb4	Receptor protein-tyrosine kinase. (1450 aa)
	LOC102236685	Neuregulin 2b. (714 aa)
	LOC102232504	Non-specific serine/threonine protein kinase. (503 aa)
	arhgap35	Uncharacterized protein. (1552 aa)
	ENSXMAP00000029947	EGF-like domain-containing protein. (104 aa)
	elmod3	ELMO/CED-12 domain containing 3. (412 aa)
	LOC102225708	Erb-b2 receptor tyrosine kinase 3b. (1365 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	LOC102232586	Suppressor of cytokine signaling 3. (208 aa)
	LOC111606142	Receptor protein-tyrosine kinase. (1132 aa)
	LOC102237954	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	gpnmb	Glycoprotein (transmembrane) nmb. (622 aa)
	ENSXMAP00000036141	Ubiquitin-like domain-containing protein. (75 aa)
	ENSXMAP00000036386	EGF-like domain-containing protein. (96 aa)
	erbb2	Receptor protein-tyrosine kinase. (1286 aa)
	btc	EGF-like domain-containing protein. (189 aa)
	LOC102222159	Uncharacterized protein. (1175 aa)
	LOC102237712	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (566 aa)
	LOC102236328	Tyrosine-protein kinase. (502 aa)
	LOC102218757	Uncharacterized protein. (286 aa)
	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (1607 aa)
	LOC102223666	EGF-like domain-containing protein. (623 aa)
	LOC102227363	KH domain containing, RNA binding, signal transduction associated 1b. (372 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	ENSXMAP00000036141	ENSXMAP00000020890	ENSXMAP00000036141	Cold shock domain containing E1, RNA-binding.	Ubiquitin-like domain-containing protein.	0.453
CSDE1	LOC102225708	ENSXMAP00000020890	ENSXMAP00000032209	Cold shock domain containing E1, RNA-binding.	Erb-b2 receptor tyrosine kinase 3b.	0.493
CSDE1	LOC102225731	ENSXMAP00000020890	ENSXMAP00000011881	Cold shock domain containing E1, RNA-binding.	Rho GTPase activating protein 35b.	0.405
CSDE1	LOC102228937	ENSXMAP00000020890	ENSXMAP00000008832	Cold shock domain containing E1, RNA-binding.	Melanoma receptor tyrosine-protein kinase; Probable receptor with tyrosine-protein kinase activity.	0.493
CSDE1	LOC102231767	ENSXMAP00000020890	ENSXMAP00000016128	Cold shock domain containing E1, RNA-binding.	Receptor protein-tyrosine kinase.	0.493
CSDE1	LOC102236062	ENSXMAP00000020890	ENSXMAP00000016567	Cold shock domain containing E1, RNA-binding.	Receptor protein-tyrosine kinase.	0.493
CSDE1	LOC102236328	ENSXMAP00000020890	ENSXMAP00000038260	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.436
CSDE1	LOC111606142	ENSXMAP00000020890	ENSXMAP00000034439	Cold shock domain containing E1, RNA-binding.	Receptor protein-tyrosine kinase.	0.493
CSDE1	M3ZJA3_XIPMA	ENSXMAP00000020890	ENSXMAP00000002295	Cold shock domain containing E1, RNA-binding.	Epidermal growth factor.	0.501
CSDE1	M4A2Z4_XIPMA	ENSXMAP00000020890	ENSXMAP00000008838	Cold shock domain containing E1, RNA-binding.	Receptor protein-tyrosine kinase.	0.493
CSDE1	Uba52	ENSXMAP00000020890	ENSXMAP00000003931	Cold shock domain containing E1, RNA-binding.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.492
CSDE1	arhgap35	ENSXMAP00000020890	ENSXMAP00000029773	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.405
CSDE1	btc	ENSXMAP00000020890	ENSXMAP00000037524	Cold shock domain containing E1, RNA-binding.	EGF-like domain-containing protein.	0.439
CSDE1	erbb2	ENSXMAP00000020890	ENSXMAP00000036809	Cold shock domain containing E1, RNA-binding.	Receptor protein-tyrosine kinase.	0.493
CSDE1	erbb3	ENSXMAP00000020890	ENSXMAP00000001973	Cold shock domain containing E1, RNA-binding.	Protein kinase domain-containing protein.	0.493
CSDE1	erbb4	ENSXMAP00000020890	ENSXMAP00000029096	Cold shock domain containing E1, RNA-binding.	Receptor protein-tyrosine kinase.	0.493
CSDE1	hbegf	ENSXMAP00000020890	ENSXMAP00000010024	Cold shock domain containing E1, RNA-binding.	Heparin-binding EGF-like growth factor.	0.444
CSDE1	ptk6	ENSXMAP00000020890	ENSXMAP00000009184	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.436
CSDE1	rasa1	ENSXMAP00000020890	ENSXMAP00000019463	Cold shock domain containing E1, RNA-binding.	RAS p21 protein activator (GTPase activating protein) 1a.	0.800
CSDE1	rps27a	ENSXMAP00000020890	ENSXMAP00000000166	Cold shock domain containing E1, RNA-binding.	Ribosomal protein S27a.	0.492