(54 nodes) RHOBTB GTPase Cycle network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CDC37	Cell division cycle 37 homolog (S. cerevisiae). (375 aa)
	rhobtb2	Rho related BTB domain containing 2a. (720 aa)
	LOC102234929	Transformer 2 beta homolog. (279 aa)
	cops2	COP9 signalosome subunit 2. (443 aa)
	rock1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1380 aa)
	dazap1	DAZ associated protein 1. (435 aa)
	scaf4	Uncharacterized protein. (1210 aa)
	cpsf6	Cleavage and polyadenylation specific factor 6. (586 aa)
	stk38	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (451 aa)
	myo6	Myosin VIa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (955 aa)
	MYO6	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1253 aa)
	LOC102218115	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2. (733 aa)
	LOC102218377	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1. (724 aa)
	LOC102232683	E3 ubiquitin protein ligase. (1023 aa)
	cct7	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (546 aa)
	rock2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1377 aa)
	LOC102230228	RRM domain-containing protein. (306 aa)
	LOC102235721	RRM domain-containing protein. (194 aa)
	LOC102221121	Cullin 3; Belongs to the cullin family. (767 aa)
	txnl1	Thioredoxin-like 1. (289 aa)
	LOC102221893	Phosphodiesterase. (778 aa)
	LOC102235624	CULLIN_2 domain-containing protein; Belongs to the cullin family. (766 aa)
	LOC102236272	Uncharacterized protein. (378 aa)
	LOC102218394	Uncharacterized protein. (375 aa)
	LOC102216487	Vimentin like; Belongs to the intermediate filament family. (455 aa)
	LOC102219317	Heat shock protein 90, alpha (cytosolic), class B member 1. (723 aa)
	gps1	G protein pathway suppressor 1. (486 aa)
	LOC102220933	Uncharacterized protein. (348 aa)
	SCAF8	SR-related CTD associated factor 8. (1380 aa)
	cirbp	Cold inducible RNA binding protein b. (183 aa)
	LOC102223222	Twinfilin actin-binding protein 2b. (368 aa)
	rbmx	RNA binding motif protein X-linked. (383 aa)
	LOC102234696	Rho related BTB domain containing 4. (734 aa)
	pde5a	Phosphodiesterase. (805 aa)
	ENSXMAP00000026632	DWNN domain-containing protein. (131 aa)
	LOC102229312	RRM domain-containing protein. (305 aa)
	msi2	Musashi RNA-binding protein 2a. (407 aa)
	cct2	Chaperonin containing TCP1, subunit 2 (beta). (535 aa)
	LOC102232126	Si:ch1073-335m2.2. (3137 aa)
	msi1	Musashi RNA binding protein 1. (421 aa)
	LOC102217935	Uncharacterized protein. (195 aa)
	Rbbp6	Uncharacterized protein. (177 aa)
	srrm1	Serine/arginine repetitive matrix 1. (862 aa)
	ENSXMAP00000034358	Uncharacterized protein. (1756 aa)
	tmod3	Tropomodulin 2. (360 aa)
	ralyl	RRM domain-containing protein. (305 aa)
	spen	Spen family transcriptional repressor. (3524 aa)
	LOC102229287	RALY RNA binding protein like. (312 aa)
	cops4	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis). (406 aa)
	ENSXMAP00000039239	CID domain-containing protein. (162 aa)
	LOC102216475	Twinfilin actin-binding protein 1a. (429 aa)
	LOC102236014	Uncharacterized protein. (398 aa)
	twf2	Twinfilin actin-binding protein 2a. (352 aa)
	actb	Uncharacterized protein. (378 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC37	LOC102218115	ENSXMAP00000000248	ENSXMAP00000008332	Cell division cycle 37 homolog (S. cerevisiae).	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	0.869
CDC37	LOC102218377	ENSXMAP00000000248	ENSXMAP00000008338	Cell division cycle 37 homolog (S. cerevisiae).	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.869
CDC37	LOC102219317	ENSXMAP00000000248	ENSXMAP00000017367	Cell division cycle 37 homolog (S. cerevisiae).	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.857
CDC37	LOC102234696	ENSXMAP00000000248	ENSXMAP00000025459	Cell division cycle 37 homolog (S. cerevisiae).	Rho related BTB domain containing 4.	0.484
CDC37	rhobtb2	ENSXMAP00000000248	ENSXMAP00000001163	Cell division cycle 37 homolog (S. cerevisiae).	Rho related BTB domain containing 2a.	0.484
ENSXMAP00000026632	LOC102234696	ENSXMAP00000026632	ENSXMAP00000025459	DWNN domain-containing protein.	Rho related BTB domain containing 4.	0.466
ENSXMAP00000026632	rhobtb2	ENSXMAP00000026632	ENSXMAP00000001163	DWNN domain-containing protein.	Rho related BTB domain containing 2a.	0.466
ENSXMAP00000034358	LOC102234696	ENSXMAP00000034358	ENSXMAP00000025459	Uncharacterized protein.	Rho related BTB domain containing 4.	0.466
ENSXMAP00000034358	rhobtb2	ENSXMAP00000034358	ENSXMAP00000001163	Uncharacterized protein.	Rho related BTB domain containing 2a.	0.466
LOC102216475	LOC102218394	ENSXMAP00000039475	ENSXMAP00000015575	Twinfilin actin-binding protein 1a.	Uncharacterized protein.	0.562
LOC102216475	LOC102234696	ENSXMAP00000039475	ENSXMAP00000025459	Twinfilin actin-binding protein 1a.	Rho related BTB domain containing 4.	0.483
LOC102216475	LOC102236014	ENSXMAP00000039475	ENSXMAP00000040323	Twinfilin actin-binding protein 1a.	Uncharacterized protein.	0.562
LOC102216475	LOC102236272	ENSXMAP00000039475	ENSXMAP00000015215	Twinfilin actin-binding protein 1a.	Uncharacterized protein.	0.562
LOC102216475	actb	ENSXMAP00000039475	ENSXMAP00000000983	Twinfilin actin-binding protein 1a.	Uncharacterized protein.	0.562
LOC102216475	rhobtb2	ENSXMAP00000039475	ENSXMAP00000001163	Twinfilin actin-binding protein 1a.	Rho related BTB domain containing 2a.	0.483
LOC102216475	tmod3	ENSXMAP00000039475	ENSXMAP00000034992	Twinfilin actin-binding protein 1a.	Tropomodulin 2.	0.437
LOC102217935	LOC102230228	ENSXMAP00000031471	ENSXMAP00000009357	Uncharacterized protein.	RRM domain-containing protein.	0.538
LOC102218115	CDC37	ENSXMAP00000008332	ENSXMAP00000000248	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Cell division cycle 37 homolog (S. cerevisiae).	0.869
LOC102218115	LOC102218377	ENSXMAP00000008332	ENSXMAP00000008338	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.900
LOC102218115	LOC102218394	ENSXMAP00000008332	ENSXMAP00000015575	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Uncharacterized protein.	0.450