28 items (Xiphophorus maculatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	kif1b	Kinesin family member 1B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1787 aa)
	mdc1	Uncharacterized protein. (2106 aa)
	slmap	Sarcolemma associated protein a. (791 aa)
	nbn	Nibrin. (831 aa)
	LOC102232462	Centrosomal protein 170B. (1602 aa)
	kif14	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1085 aa)
	LOC102224037	Checkpoint kinase 2. (442 aa)
	kif13b	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1748 aa)
	chfr	Checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase. (627 aa)
	LOC102225825	Kinesin family member 1Aa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1593 aa)
	mcrs1	Microspherule protein 1. (473 aa)
	LOC102229966	Forkhead box K1. (661 aa)
	ppp1r8	Protein phosphatase 1, regulatory subunit 8b. (381 aa)
	ENSXMAP00000034788	FHA domain-containing protein. (105 aa)
	SNIP1-2	Smad nuclear interacting protein 1. (271 aa)
	tcf19	Transcription factor 19 (SC1), like. (556 aa)
	aggf1	Angiogenic factor with G patch and FHA domains 1. (750 aa)
	slc4a1ap	Solute carrier family 4 member 1 adaptor protein. (751 aa)
	cep170	Centrosomal protein 170Aa. (1587 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (473 aa)
	LOC102218078	Kinesin family member 1Ab; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1565 aa)
	SNIP1	Smad nuclear interacting protein 1. (365 aa)
	LOC102222551	Marker of proliferation Ki-67. (1766 aa)
	kif13a	Kinesin family member 13A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1846 aa)
	LOC102218968	Forkhead box K2. (602 aa)
	LOC102219853	PH domain-containing protein. (1505 aa)
	LOC102237530	Kinesin family member 13Ba; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1728 aa)
	foxk2	Uncharacterized protein. (620 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102224037	mdc1	ENSXMAP00000001234	ENSXMAP00000010999	Checkpoint kinase 2.	Uncharacterized protein.	0.715
LOC102224037	nbn	ENSXMAP00000001234	ENSXMAP00000006994	Checkpoint kinase 2.	Nibrin.	0.850
LOC102224037	rnf8	ENSXMAP00000001234	ENSXMAP00000017393	Checkpoint kinase 2.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.781
LOC102237530	kif14	ENSXMAP00000011694	ENSXMAP00000006052	Kinesin family member 13Ba; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.409
kif13a	kif14	ENSXMAP00000014063	ENSXMAP00000006052	Kinesin family member 13A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.409
kif13b	kif14	ENSXMAP00000001819	ENSXMAP00000006052	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.409
kif14	LOC102237530	ENSXMAP00000006052	ENSXMAP00000011694	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 13Ba; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.409
kif14	kif13a	ENSXMAP00000006052	ENSXMAP00000014063	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family member 13A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.409
kif14	kif13b	ENSXMAP00000006052	ENSXMAP00000001819	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.409
mdc1	LOC102224037	ENSXMAP00000010999	ENSXMAP00000001234	Uncharacterized protein.	Checkpoint kinase 2.	0.715
mdc1	nbn	ENSXMAP00000010999	ENSXMAP00000006994	Uncharacterized protein.	Nibrin.	0.909
mdc1	rnf8	ENSXMAP00000010999	ENSXMAP00000017393	Uncharacterized protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.892
nbn	LOC102224037	ENSXMAP00000006994	ENSXMAP00000001234	Nibrin.	Checkpoint kinase 2.	0.850
nbn	mdc1	ENSXMAP00000006994	ENSXMAP00000010999	Nibrin.	Uncharacterized protein.	0.909
nbn	rnf8	ENSXMAP00000006994	ENSXMAP00000017393	Nibrin.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.777
rnf8	LOC102224037	ENSXMAP00000017393	ENSXMAP00000001234	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	Checkpoint kinase 2.	0.781
rnf8	mdc1	ENSXMAP00000017393	ENSXMAP00000010999	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	Uncharacterized protein.	0.892
rnf8	nbn	ENSXMAP00000017393	ENSXMAP00000006994	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	Nibrin.	0.777