STRINGSTRING
mcm2 mcm2 LOC102236362 LOC102236362 LOC102219021 LOC102219021 ccne1 ccne1 LOC102222169 LOC102222169 LOC102216881 LOC102216881 ccnd1 ccnd1 LOC102235820 LOC102235820 anapc10 anapc10 prkdc prkdc e2f4 e2f4 myc myc ccna2 ccna2 espl1 espl1 cdk4 cdk4 LOC102222783 LOC102222783 LOC102223216 LOC102223216 cdk2 cdk2 smad3 smad3 LOC102235592 LOC102235592 LOC102229551 LOC102229551 TGFB3 TGFB3 gsk3b gsk3b cdc7 cdc7 anapc7 anapc7 LOC102224322 LOC102224322 LOC102230576 LOC102230576 orc5 orc5 e2f1 e2f1 LOC102225329 LOC102225329 LOC102228719 LOC102228719 cdkn2b cdkn2b LOC102224900 LOC102224900 cdc25b cdc25b bub1b bub1b dbf4 dbf4 smc3 smc3 ttk ttk cdc26 cdc26 orc3 orc3 skp1 skp1 LOC102237928 LOC102237928 ccnb1 ccnb1 rad21 rad21 LOC102237816 LOC102237816 LOC102220833 LOC102220833 LOC102235773 LOC102235773 LOC102226082 LOC102226082 orc4 orc4 LOC102230338 LOC102230338 chek1 chek1 smc1a smc1a tfdp1 tfdp1 e2f2 e2f2 cdc27 cdc27 wee1 wee1 PLK1 PLK1 GADD45B GADD45B cdc16 cdc16 LOC102217509 LOC102217509 LOC102238282 LOC102238282 LOC102219174 LOC102219174 LOC102220824 LOC102220824 cdc6 cdc6 LOC102226168 LOC102226168 rbl1 rbl1 tgfb3 tgfb3 cdk1 cdk1 cdc45 cdc45 pcna pcna ccnb3 ccnb3 LOC102220374 LOC102220374 gadd45g gadd45g mcm7 mcm7 bub3 bub3 YWHAB YWHAB anapc11 anapc11 M4AUE5_XIPMA M4AUE5_XIPMA mcm6 mcm6 pkmyt1 pkmyt1 HDAC2 HDAC2 FZR1 FZR1 mad2l2 mad2l2 ccnh ccnh abl1 abl1 LOC102221134 LOC102221134 ccne2 ccne2 LOC102221941 LOC102221941 LOC102221373 LOC102221373 LOC102234824 LOC102234824 LOC102225050 LOC102225050 LOC102231604 LOC102231604 LOC102218733 LOC102218733 LOC102225733 LOC102225733 mad2l1 mad2l1 cdc20 cdc20 LOC102225350 LOC102225350 LOC102228793 LOC102228793 tp53 tp53 e2f3 e2f3 rbx1 rbx1 rb1 rb1 cdkn2c cdkn2c cdc14a cdc14a cdc23 cdc23 LOC102221730 LOC102221730 SMAD4 SMAD4 anapc2 anapc2 cdk6 cdk6 anapc4 anapc4 cdk7 cdk7 LOC102236683 LOC102236683 GADD45B-2 GADD45B-2 Cul1 Cul1 ENSXMAP00000035241 ENSXMAP00000035241 anapc13 anapc13 LOC102221028 LOC102221028 orc2 orc2 cdkn2d cdkn2d ENSXMAP00000036885 ENSXMAP00000036885 mcm3 mcm3 orc1 orc1 zbtb17 zbtb17 gadd45a gadd45a LOC102219871 LOC102219871 LOC102236163 LOC102236163 mcm4 mcm4 anapc5 anapc5 Bub1 Bub1 SMAD3 SMAD3 ENSXMAP00000041178 ENSXMAP00000041178 stag1 stag1 Stag3 Stag3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mcm2DNA helicase; Belongs to the MCM family. (886 aa)
LOC102236362Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (464 aa)
LOC102219021Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family. (257 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (434 aa)
LOC102222169Cyclin-dependent kinase inhibitor 1A. (207 aa)
LOC102216881Transforming growth factor beta; Belongs to the TGF-beta family. (394 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
LOC102235820Si:ch211-269e2.1. (1177 aa)
anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (186 aa)
prkdcProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4072 aa)
e2f4E2F transcription factor 4. (389 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (432 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (432 aa)
espl1Extra spindle pole bodies like 1, separase. (2165 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (316 aa)
LOC10222278314_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa)
LOC102223216Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
smad3Mothers against decapentaplegic homolog. (425 aa)
LOC102235592E1A binding protein p300 b. (2751 aa)
LOC102229551BHLH domain-containing protein. (357 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
gsk3bGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (423 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (606 aa)
anapc7Anaphase promoting complex subunit 7. (565 aa)
LOC102224322Mothers against decapentaplegic homolog. (467 aa)
LOC102230576CREB binding protein b. (2446 aa)
orc5Origin recognition complex, subunit 5. (442 aa)
e2f1E2F transcription factor 1. (456 aa)
LOC102225329Retinoblastoma-like 2 (p130). (1063 aa)
LOC102228719Mothers against decapentaplegic homolog. (503 aa)
cdkn2bCyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (124 aa)
LOC102224900Wee1-like protein kinase. (526 aa)
cdc25bRhodanese domain-containing protein. (573 aa)
bub1bBUB1 mitotic checkpoint serine/threonine kinase Bb. (430 aa)
dbf4DBF4 zinc finger. (593 aa)
smc3Structural maintenance of chromosomes protein. (1217 aa)
ttkTtk protein kinase. (916 aa)
cdc26Cell division cycle 26 homolog. (94 aa)
orc3Origin recognition complex, subunit 3. (722 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
LOC102237928Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily. (318 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (401 aa)
rad21RAD21 cohesin complex component a. (637 aa)
LOC10223781614_3_3 domain-containing protein; Belongs to the 14-3-3 family. (244 aa)
LOC102220833Structural maintenance of chromosomes protein. (1237 aa)
LOC102235773Cyclin-dependent kinase inhibitor 1Bb. (194 aa)
LOC102226082E1A binding protein p300 a. (2737 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
LOC102230338Cyclin D2, a; Belongs to the cyclin family. (296 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (455 aa)
smc1aStructural maintenance of chromosomes protein. (1231 aa)
tfdp1Transcription factor. (410 aa)
e2f2Si:ch211-160f23.5. (472 aa)
cdc27Cell division cycle 27. (803 aa)
wee1Wee1-like protein kinase. (620 aa)
PLK1Serine/threonine-protein kinase PLK. (582 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (618 aa)
LOC102217509Uncharacterized protein. (177 aa)
LOC102238282RAD21 cohesin complex component b. (642 aa)
LOC102219174Uncharacterized protein. (393 aa)
LOC102220824Cyclin Dx; Belongs to the cyclin family. (294 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (579 aa)
LOC102226168Cyclin B2; Belongs to the cyclin family. (384 aa)
rbl1Retinoblastoma-like 1 (p107). (1055 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
cdk1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (325 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (570 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
ccnb3Cyclin B3; Belongs to the cyclin family. (431 aa)
LOC102220374Myelocytomatosis oncogene homolog. (355 aa)
gadd45gGrowth arrest and DNA-damage-inducible, gamma a. (159 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (724 aa)
bub3BUB3 mitotic checkpoint protein. (326 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b; Belongs to the 14-3-3 family. (244 aa)
anapc11APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
M4AUE5_XIPMARad21_Rec8_N domain-containing protein. (125 aa)
mcm6DNA helicase; Belongs to the MCM family. (816 aa)
pkmyt1Protein kinase, membrane associated tyrosine/threonine 1. (577 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (490 aa)
FZR1Fizzy/cell division cycle 20 related 1a. (497 aa)
mad2l2Mitotic arrest deficient 2 like 2. (210 aa)
ccnhCyclin H; Belongs to the cyclin family. (319 aa)
abl1Tyrosine-protein kinase. (1152 aa)
LOC102221134CREB binding protein a. (2460 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (394 aa)
LOC102221941Cyclin-dependent kinase inhibitor 1Cb. (216 aa)
LOC102221373Cyclin D3; Belongs to the cyclin family. (316 aa)
LOC102234824Ribosomal_L7Ae domain-containing protein. (157 aa)
LOC102225050Fizzy/cell division cycle 20 related 1b. (487 aa)
LOC102231604Stromal antigen 2a. (1275 aa)
LOC1022187333-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa)
LOC102225733Cyclin D2, b; Belongs to the cyclin family. (294 aa)
mad2l1MAD2 mitotic arrest deficient-like 1 (yeast). (202 aa)
cdc20Cell division cycle 20 homolog. (551 aa)
LOC102225350Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
LOC102228793Cyclin-dependent kinase inhibitor 1D. (178 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (342 aa)
e2f3E2F transcription factor 3. (446 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (149 aa)
rb1Retinoblastoma susceptibility protein. (912 aa)
cdkn2cCyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (162 aa)
cdc14aCell division cycle 14Ab. (647 aa)
cdc23CDC23 (cell division cycle 23, yeast, homolog). (575 aa)
LOC1022217303-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1; Belongs to the 14-3-3 family. (247 aa)
SMAD4Mothers against decapentaplegic homolog. (512 aa)
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (809 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (802 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
LOC102236683Stromal antigen 2b. (1275 aa)
GADD45B-2Growth arrest and DNA damage inducible beta. (153 aa)
Cul1Cullin 1b; Belongs to the cullin family. (332 aa)
ENSXMAP00000035241Uncharacterized protein. (167 aa)
anapc13Anaphase promoting complex subunit 13. (74 aa)
LOC102221028Uncharacterized protein. (174 aa)
orc2Origin recognition complex, subunit 2. (594 aa)
cdkn2dCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
ENSXMAP00000036885E2F_TDP domain-containing protein. (102 aa)
mcm3DNA helicase; Belongs to the MCM family. (836 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (890 aa)
zbtb17Zinc finger and BTB domain containing 17. (965 aa)
gadd45aGrowth arrest and DNA-damage-inducible, alpha, a. (162 aa)
LOC102219871Cell division cycle 14B. (621 aa)
LOC10223616314_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
mcm4DNA helicase; Belongs to the MCM family. (868 aa)
anapc5Anaphase promoting complex subunit 5. (773 aa)
Bub1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (210 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ENSXMAP00000041178E2F transcription factor 5. (149 aa)
stag1Stromal antigen 1a. (1260 aa)
Stag3SCD domain-containing protein. (116 aa)
Your Current Organism:
Xiphophorus maculatus
NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish
Server load: low (34%) [HD]