STRINGSTRING
LOC102225395 LOC102225395 RAB39B RAB39B LOC102219029 LOC102219029 rheb rheb atg16l1 atg16l1 pik3r4 pik3r4 wipi2 wipi2 atg10 atg10 ern1 ern1 Mtor Mtor rab39b rab39b LOC102238002 LOC102238002 mras mras LOC102217419 LOC102217419 eif2ak3 eif2ak3 LOC102236577 LOC102236577 LOC102227528 LOC102227528 tbk1 tbk1 LOC102229074 LOC102229074 atg2a atg2a LOC102223582 LOC102223582 dapk2 dapk2 rab8a rab8a map2k1 map2k1 smcr8 smcr8 atg4b atg4b LOC102222087 LOC102222087 LOC102236194 LOC102236194 atg13 atg13 mapk10 mapk10 LOC102225882 LOC102225882 LOC102236184 LOC102236184 rps6kb2 rps6kb2 c9orf72 c9orf72 map3k7 map3k7 MTMR4 MTMR4 LOC102229002 LOC102229002 LOC102231865 LOC102231865 ulk2 ulk2 mapk1 mapk1 akt1 akt1 ambra1 ambra1 LOC102234718 LOC102234718 EIF2AK4 EIF2AK4 LOC102235796 LOC102235796 RUBCNL RUBCNL itpr1 itpr1 ppp2ca ppp2ca LOC102231753 LOC102231753 LOC102218230 LOC102218230 supt20h supt20h LOC102231511 LOC102231511 LOC102223271 LOC102223271 LOC102223777 LOC102223777 BCL2L1 BCL2L1 atg3 atg3 atg9a atg9a becn1 becn1 LOC102232828 LOC102232828 LOC102230347 LOC102230347 LOC102217081 LOC102217081 prkaa2 prkaa2 atg4c atg4c LOC102218600 LOC102218600 LOC102230526 LOC102230526 LOC102232995 LOC102232995 traf6 traf6 atg12 atg12 LOC102229095 LOC102229095 prkaca prkaca akt2 akt2 bnip3 bnip3 pten pten stx17 stx17 LOC102236796 LOC102236796 LOC102232287 LOC102232287 atg101 atg101 LOC102216436 LOC102216436 akt1s1 akt1s1 nrbf2 nrbf2 snap29 snap29 ZFYVE1 ZFYVE1 igbp1 igbp1 LOC102235425 LOC102235425 LOC102226863 LOC102226863 LOC102224423 LOC102224423 LOC102220980 LOC102220980 dapk1 dapk1 LOC102218920 LOC102218920 cflar cflar gabarapl2 gabarapl2 LOC102237217 LOC102237217 LOC102232039 LOC102232039 prkaa1 prkaa1 ctsd ctsd pik3r1 pik3r1 wdr41 wdr41 pdpk1 pdpk1 rb1cc1 rb1cc1 lamp1 lamp1 stk11 stk11 atg14 atg14 LOC102228613 LOC102228613 LOC102226157 LOC102226157 lamp2 lamp2 hif1a hif1a atg5 atg5 bcl2l1 bcl2l1 LOC102229304 LOC102229304 prkcq prkcq Sqstm1 Sqstm1 LOC102219790 LOC102219790 pik3cb pik3cb ENSXMAP00000023198 ENSXMAP00000023198 prkacb prkacb pik3c3 pik3c3 pik3r3 pik3r3 LOC102237237 LOC102237237 hras hras rptor rptor bad bad LOC102230641 LOC102230641 LOC102237756 LOC102237756 LOC102237609 LOC102237609 Atg2b Atg2b LOC102232721 LOC102232721 eif2s1 eif2s1 LOC102234512 LOC102234512 LOC102237032 LOC102237032 ddit4 ddit4 map2k2 map2k2 ulk1 ulk1 mlst8 mlst8 LOC102232504 LOC102232504 rragc rragc pik3cd pik3cd LOC102221039 LOC102221039 ppp2cb ppp2cb LOC102238067 LOC102238067 ins ins LOC102233604 LOC102233604 atg7 atg7 uvrag uvrag LOC102230535 LOC102230535 LOC102227153 LOC102227153 dapk3 dapk3 LOC102221045 LOC102221045 rubcn rubcn LOC102231309 LOC102231309 bcl2 bcl2 tank tank LOC102233859 LOC102233859 mapk8 mapk8 LOC102225207 LOC102225207 LOC102236425 LOC102236425 LOC102222042 LOC102222042 LOC102234094 LOC102234094 LOC102237954 LOC102237954 LOC102226857 LOC102226857 LOC102233436 LOC102233436 deptor deptor gabarap gabarap mtmr14 mtmr14 LOC102229676 LOC102229676 LOC102219409 LOC102219409 VMP1 VMP1 WIPI1 WIPI1 ENSXMAP00000039056 ENSXMAP00000039056 LOC102235279 LOC102235279 LOC102237985 LOC102237985 prkcd prkcd
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102225395Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (509 aa)
RAB39BRAB39B, member RAS oncogene family. (213 aa)
LOC102219029TSC complex subunit 1. (977 aa)
rhebUncharacterized protein. (183 aa)
atg16l1ATG16 autophagy related 16-like 1 (S. cerevisiae). (603 aa)
pik3r4Phosphoinositide-3-kinase, regulatory subunit 4. (1325 aa)
wipi2WD repeat domain, phosphoinositide interacting 2. (427 aa)
atg10ATG10 autophagy related 10 homolog (S. cerevisiae). (238 aa)
ern1Endoplasmic reticulum to nucleus signaling 1. (1060 aa)
MtorSerine/threonine-protein kinase TOR. (1011 aa)
rab39bUncharacterized protein. (213 aa)
LOC102238002Unc-51 like autophagy activating kinase 1a. (892 aa)
mrasMuscle RAS oncogene homolog. (208 aa)
LOC102217419Inositol 1,4,5-trisphosphate receptor, type 1a. (2694 aa)
eif2ak3Eukaryotic translation initiation factor 2-alpha kinase 3. (1101 aa)
LOC102236577Uncharacterized protein. (408 aa)
LOC102227528Si:ch211-11n16.2. (655 aa)
tbk1TANK-binding kinase 1. (721 aa)
LOC102229074Uncharacterized protein. (213 aa)
atg2aAutophagy related 2A. (1998 aa)
LOC102223582Hypoxia inducible factor 1 subunit alpha, like. (650 aa)
dapk2Death-associated protein kinase 2b; Belongs to the protein kinase superfamily. (363 aa)
rab8aRAB8A, member RAS oncogene family. (206 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
smcr8Smith-Magenis syndrome chromosome region, candidate 8a. (960 aa)
atg4bCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (445 aa)
LOC102222087Cathepsin Bb; Belongs to the peptidase C1 family. (330 aa)
LOC102236194RAB33B, member RAS oncogene family a. (240 aa)
atg13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (538 aa)
mapk10Mitogen-activated protein kinase. (401 aa)
LOC102225882Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC102236184Zgc:171927. (214 aa)
rps6kb2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (470 aa)
c9orf72Zgc:100846. (462 aa)
map3k7Mitogen-activated protein kinase kinase kinase 7. (600 aa)
MTMR4Myotubularin related protein 4. (1186 aa)
LOC102229002Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (809 aa)
LOC102231865Uncharacterized protein. (203 aa)
ulk2Unc-51 like autophagy activating kinase 2. (1041 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
ambra1Autophagy/beclin-1 regulator 1b. (1369 aa)
LOC102234718Zinc finger, FYVE domain containing 1. (776 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1652 aa)
LOC102235796Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (499 aa)
RUBCNLRubicon like autophagy enhancer. (741 aa)
itpr1Inositol 1,4,5-trisphosphate receptor, type 1b. (2671 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
LOC102231753High mobility group box 1b. (200 aa)
LOC102218230Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
supt20hSPT20 homolog, SAGA complex component. (831 aa)
LOC102231511Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (456 aa)
LOC102223271Death-associated protein kinase 2a; Belongs to the protein kinase superfamily. (486 aa)
LOC102223777Serine/threonine-protein phosphatase. (309 aa)
BCL2L1BCL2 like 1. (219 aa)
atg3Autophagy-related protein 3. (315 aa)
atg9aAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (853 aa)
becn1Beclin 1, autophagy related. (448 aa)
LOC102232828WD repeat domain, phosphoinositide interacting 1. (451 aa)
LOC102230347Cathepsin 12; Belongs to the peptidase C1 family. (337 aa)
LOC102217081Zgc:101559. (234 aa)
prkaa2Non-specific serine/threonine protein kinase. (629 aa)
atg4cCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (477 aa)
LOC102218600Zgc:92606. (117 aa)
LOC102230526Lysosomal associated membrane protein 1. (253 aa)
LOC102232995Zgc:55558. (187 aa)
traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
atg12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (135 aa)
LOC102229095Ras-related GTP binding A. (315 aa)
prkacaProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
bnip3BCL2 interacting protein 3. (191 aa)
ptenPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (441 aa)
stx17Syntaxin 17; Belongs to the syntaxin family. (298 aa)
LOC102236796Uncharacterized protein. (384 aa)
LOC102232287Protein kinase domain-containing protein. (549 aa)
atg101Autophagy related 101. (215 aa)
LOC102216436Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (728 aa)
akt1s1AKT1 substrate 1 (proline-rich). (351 aa)
nrbf2Nuclear receptor binding factor 2b. (303 aa)
snap29Synaptosome associated protein 29. (258 aa)
ZFYVE1Uncharacterized protein. (783 aa)
igbp1Immunoglobulin (CD79A) binding protein 1. (358 aa)
LOC102235425Uncharacterized protein. (726 aa)
LOC102226863Insulin receptor substrate 2a. (1061 aa)
LOC102224423Si:ch73-335l21.1. (1276 aa)
LOC102220980UDENN FLCN/SMCR8-type domain-containing protein. (880 aa)
dapk1Death-associated protein kinase 1. (1441 aa)
LOC102218920Uncharacterized protein. (202 aa)
cflarUncharacterized protein; Belongs to the peptidase C14A family. (422 aa)
gabarapl2GABA(A) receptor-associated protein like 2. (116 aa)
LOC102237217Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
LOC102232039Si:dkey-240h12.4; Belongs to the protein kinase superfamily. (361 aa)
prkaa1Non-specific serine/threonine protein kinase. (564 aa)
ctsdCathepsin D; Belongs to the peptidase A1 family. (396 aa)
pik3r1Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (727 aa)
wdr41WD repeat domain 41. (447 aa)
pdpk13-phosphoinositide dependent protein kinase 1b. (565 aa)
rb1cc1RB1-inducible coiled-coil 1. (1616 aa)
lamp1Lysosomal associated membrane protein 1a. (418 aa)
stk11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
atg14Autophagy related 14. (506 aa)
LOC102228613Si:ch73-62l21.1. (351 aa)
LOC102226157Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1152 aa)
lamp2Lysosomal-associated membrane protein 2. (416 aa)
hif1aHypoxia inducible factor 1 subunit alpha a. (758 aa)
atg5Autophagy protein 5; Involved in autophagic vesicle formation. (326 aa)
bcl2l1BH4_2 domain-containing protein. (227 aa)
LOC102229304Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
prkcqProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (719 aa)
Sqstm1Uncharacterized protein. (96 aa)
LOC102219790RAB7a, member RAS oncogene family. (207 aa)
pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
ENSXMAP00000023198Si:ch73-234b20.5. (102 aa)
prkacbUncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (879 aa)
pik3r3Uncharacterized protein. (473 aa)
LOC102237237Mitogen-activated protein kinase. (420 aa)
hrasHRas proto-oncogene, GTPase a. (211 aa)
rptorRegulatory associated protein of MTOR, complex 1. (1381 aa)
badBCL2 associated agonist of cell death b. (166 aa)
LOC102230641Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
LOC102237756TSC complex subunit 1b. (1243 aa)
LOC102237609Cathepsin L.1; Belongs to the peptidase C1 family. (334 aa)
Atg2bAutophagy related 2B. (292 aa)
LOC102232721SH3-domain GRB2-like endophilin B1a. (365 aa)
eif2s1Eukaryotic translation initiation factor 2, subunit 1 alpha b. (315 aa)
LOC102234512Ras homolog, mTORC1 binding like 1. (223 aa)
LOC102237032Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (511 aa)
ddit4DNA-damage-inducible transcript 4. (275 aa)
map2k2Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
ulk1Unc-51 like autophagy activating kinase 1. (1064 aa)
mlst8MTOR associated protein, LST8 homolog (S. cerevisiae). (326 aa)
LOC102232504Non-specific serine/threonine protein kinase. (503 aa)
rragcRas-related GTP binding Ca. (382 aa)
pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
LOC102221039Si:dkey-13a21.4. (204 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
LOC102238067High mobility group box 1a. (200 aa)
insInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (140 aa)
LOC102233604Vacuole membrane protein 1. (404 aa)
atg7ATG7 autophagy related 7 homolog (S. cerevisiae). (720 aa)
uvragUV radiation resistance associated gene. (730 aa)
LOC102230535Uncharacterized protein. (207 aa)
LOC102227153Insulin receptor substrate 2b. (1117 aa)
dapk3Death-associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
LOC102221045Tyrosine-protein kinase receptor. (1416 aa)
rubcnRubicon autophagy regulator. (983 aa)
LOC102231309Zgc:73226. (182 aa)
bcl2BCL2 apoptosis regulator b. (229 aa)
tankTRAF family member-associated NFKB activator. (338 aa)
LOC102233859Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (498 aa)
mapk8Mitogen-activated protein kinase. (384 aa)
LOC102225207Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (397 aa)
LOC102236425Insulin receptor substrate 4a. (1411 aa)
LOC102222042Protein kinase domain-containing protein. (1036 aa)
LOC102234094Mitogen-activated protein kinase. (457 aa)
LOC102237954Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC102226857RAS related. (197 aa)
LOC102233436Uncharacterized protein. (466 aa)
deptorDEP domain containing MTOR-interacting protein. (425 aa)
gabarapGABA(A) receptor-associated protein b. (122 aa)
mtmr14Myotubularin related protein 14. (657 aa)
LOC102229676Vesicle-associated membrane protein 8 (endobrevin). (122 aa)
LOC102219409RAB8A, member RAS oncogene family. (206 aa)
VMP1Vacuole membrane protein 1. (430 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (444 aa)
ENSXMAP00000039056V-SNARE coiled-coil homology domain-containing protein. (103 aa)
LOC102235279Tyrosine-protein kinase receptor. (1386 aa)
LOC102237985Uncharacterized protein; Belongs to the peptidase C1 family. (331 aa)
prkcdProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (683 aa)
Your Current Organism:
Xiphophorus maculatus
NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish
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