STRINGSTRING
LOC102219604 LOC102219604 LOC102219029 LOC102219029 calml4 calml4 LOC102223696 LOC102223696 rheb rheb ccne1 ccne1 LOC102222169 LOC102222169 LOC102216881 LOC102216881 itpr2 itpr2 Mtor Mtor ccnd1 ccnd1 mras mras e2f4 e2f4 myc myc ccna2 ccna2 LOC102217419 LOC102217419 cdk4 cdk4 LOC102236577 LOC102236577 LOC102223216 LOC102223216 foxo3 foxo3 cdk2 cdk2 map2k1 map2k1 smad3 smad3 LOC102229551 LOC102229551 TGFB3 TGFB3 mre11 mre11 calm3 calm3 LOC102233702 LOC102233702 LOC102224322 LOC102224322 LOC102225882 LOC102225882 e2f1 e2f1 LOC102217800 LOC102217800 LOC102225329 LOC102225329 LOC102224240 LOC102224240 traf3ip2 traf3ip2 cdkn2b cdkn2b LOC102224465 LOC102224465 LOC102226708 LOC102226708 igfbp3 igfbp3 rbbp4 rbbp4 mapk1 mapk1 akt1 akt1 nbn nbn vdac1 vdac1 lin9 lin9 sirt1 sirt1 mybl2 mybl2 trpv4 trpv4 itpr1 itpr1 LOC102237928 LOC102237928 LOC102217715 LOC102217715 ccnb1 ccnb1 LOC102218230 LOC102218230 LOC102232073 LOC102232073 LOC102234145 LOC102234145 LOC102224478 LOC102224478 gata4 gata4 LOC102232527 LOC102232527 rad9a rad9a LOC102231091 LOC102231091 LOC102223422 LOC102223422 LOC102223674 LOC102223674 LOC102218102 LOC102218102 LOC102217279 LOC102217279 LOC102230338 LOC102230338 chek1 chek1 LOC102219385 LOC102219385 LOC102219636 LOC102219636 LOC102232995 LOC102232995 serpine1 serpine1 LOC102223251 LOC102223251 akt2 akt2 LOC102236059 LOC102236059 e2f2 e2f2 LOC102227069 LOC102227069 hus1 hus1 pten pten GADD45B GADD45B LOC102224277 LOC102224277 LOC102216436 LOC102216436 LOC102220824 LOC102220824 LOC102232511 LOC102232511 LOC102226168 LOC102226168 TGFBR2 TGFBR2 LOC102229128 LOC102229128 rbl1 rbl1 LOC102219761 LOC102219761 tgfb3 tgfb3 cdk1 cdk1 ccnb3 ccnb3 LOC102235425 LOC102235425 LOC102221799 LOC102221799 VDAC2 VDAC2 LOC102220374 LOC102220374 LOC102217271 LOC102217271 gadd45g gadd45g LOC102221885 LOC102221885 nfatc3 nfatc3 LOC102237234 LOC102237234 pik3r1 pik3r1 LOC102217080 LOC102217080 lin54 lin54 LOC102233918 LOC102233918 LOC102226157 LOC102226157 LOC102217443 LOC102217443 LOC102229527 LOC102229527 LOC102231047 LOC102231047 ccne2 ccne2 foxm1 foxm1 LOC102225479 LOC102225479 LOC102220939 LOC102220939 Sqstm1 Sqstm1 PPP3CA PPP3CA pik3cb pik3cb LOC102221373 LOC102221373 LOC102223055 LOC102223055 LOC102227133 LOC102227133 LOC102234824 LOC102234824 LOC102223722 LOC102223722 LOC102224118 LOC102224118 pik3r3 pik3r3 LOC102223477 LOC102223477 hras hras LOC102237484 LOC102237484 LOC102235928 LOC102235928 LOC102237756 LOC102237756 LOC102225733 LOC102225733 hipk3 hipk3 IGFBP3 IGFBP3 LOC102223409 LOC102223409 LOC102237615 LOC102237615 LOC102234512 LOC102234512 LOC102228793 LOC102228793 LOC102237032 LOC102237032 lin52 lin52 LOC102233529 LOC102233529 ets1 ets1 tp53 tp53 map2k2 map2k2 e2f3 e2f3 mcu mcu LOC102223924 LOC102223924 LOC102231514 LOC102231514 LOC102232504 LOC102232504 pik3cd pik3cd slc25a4 slc25a4 ppid ppid rad1 rad1 rb1 rb1 fbxw11 fbxw11 LOC102220021 LOC102220021 LOC102223985 LOC102223985 cdk6 cdk6 LOC102217432 LOC102217432 zfp36l2 zfp36l2 LOC102233259 LOC102233259 nfatc2 nfatc2 ppp3r1 ppp3r1 LOC102221188 LOC102221188 GADD45B-2 GADD45B-2 LOC102233752 LOC102233752 foxo1 foxo1 LOC102231182 LOC102231182 LOC102237954 LOC102237954 mapkapk2 mapkapk2 LOC102229803 LOC102229803 ppp1cc ppp1cc LOC102226857 LOC102226857 LOC102233436 LOC102233436 ENSXMAP00000036885 ENSXMAP00000036885 LOC102231001 LOC102231001 gadd45a gadd45a rad50 rad50 LOC102222719 LOC102222719 LOC102232717 LOC102232717 rassf5 rassf5 SMAD3 SMAD3 ENSXMAP00000041178 ENSXMAP00000041178 LOC102217177 LOC102217177 lin37 lin37 LOC102223660 LOC102223660 LOC102225439 LOC102225439
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102219604Calpain 14; Belongs to the peptidase C2 family. (694 aa)
LOC102219029TSC complex subunit 1. (977 aa)
calml4Calmodulin-like 4a. (153 aa)
LOC102223696Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
rhebUncharacterized protein. (183 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (434 aa)
LOC102222169Cyclin-dependent kinase inhibitor 1A. (207 aa)
LOC102216881Transforming growth factor beta; Belongs to the TGF-beta family. (394 aa)
itpr2Inositol 1,4,5-trisphosphate receptor, type 2. (2636 aa)
MtorSerine/threonine-protein kinase TOR. (1011 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
mrasMuscle RAS oncogene homolog. (208 aa)
e2f4E2F transcription factor 4. (389 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (432 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (432 aa)
LOC102217419Inositol 1,4,5-trisphosphate receptor, type 1a. (2694 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (316 aa)
LOC102236577Uncharacterized protein. (408 aa)
LOC102223216Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
foxo3Forkhead protein FoxO5. (664 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
smad3Mothers against decapentaplegic homolog. (425 aa)
LOC102229551BHLH domain-containing protein. (357 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (743 aa)
calm3Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
LOC102233702Zgc:56235. (282 aa)
LOC102224322Mothers against decapentaplegic homolog. (467 aa)
LOC102225882Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
e2f1E2F transcription factor 1. (456 aa)
LOC102217800Sb:cb81. (368 aa)
LOC102225329Retinoblastoma-like 2 (p130). (1063 aa)
LOC102224240Ig-like domain-containing protein; Belongs to the MHC class I family. (389 aa)
traf3ip2SEFIR domain-containing protein. (414 aa)
cdkn2bCyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (124 aa)
LOC102224465Homeodomain interacting protein kinase 2. (1223 aa)
LOC102226708Calpain 1, (mu/I) large subunit a; Belongs to the peptidase C2 family. (712 aa)
igfbp3Insulin-like growth factor binding protein 3. (281 aa)
rbbp4Retinoblastoma binding protein 4. (424 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
nbnNibrin. (831 aa)
vdac1Voltage-dependent anion channel 1. (283 aa)
lin9Lin-9 DREAM MuvB core complex component. (547 aa)
sirt1Sirtuin 1. (694 aa)
mybl2V-myb avian myeloblastosis viral oncogene homolog-like 2b. (629 aa)
trpv4Transient receptor potential cation channel, subfamily V, member 4; Belongs to the transient receptor (TC 1.A.4) family. (859 aa)
itpr1Inositol 1,4,5-trisphosphate receptor, type 1b. (2671 aa)
LOC102237928Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily. (318 aa)
LOC102217715Zgc:55262; Belongs to the peptidase C2 family. (706 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (401 aa)
LOC102218230Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
LOC102232073Calpain 1, (mu/I) large subunit b; Belongs to the peptidase C2 family. (702 aa)
LOC102234145Calpain 2, (m/II) large subunit b; Belongs to the peptidase C2 family. (697 aa)
LOC102224478RHD domain-containing protein. (933 aa)
gata4GATA binding protein 4. (396 aa)
LOC102232527Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (328 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (389 aa)
LOC102231091RHD domain-containing protein. (880 aa)
LOC102223422Mitogen-activated protein kinase. (362 aa)
LOC102223674Mitogen-activated protein kinase. (361 aa)
LOC102218102Mitogen-activated protein kinase. (357 aa)
LOC102217279Serine/threonine-protein phosphatase. (505 aa)
LOC102230338Cyclin D2, a; Belongs to the cyclin family. (296 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (455 aa)
LOC102219385Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
LOC102219636V-rel avian reticuloendotheliosis viral oncogene homolog A. (629 aa)
LOC102232995Zgc:55558. (187 aa)
serpine1Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (463 aa)
LOC102223251Nuclear factor of activated T cells 3b. (885 aa)
akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
LOC102236059Homeodomain interacting protein kinase 1a. (1102 aa)
e2f2Si:ch211-160f23.5. (472 aa)
LOC102227069Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (299 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (271 aa)
ptenPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (441 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
LOC102224277Retinoblastoma binding protein 4, like. (416 aa)
LOC102216436Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (728 aa)
LOC102220824Cyclin Dx; Belongs to the cyclin family. (294 aa)
LOC102232511Ig-like domain-containing protein; Belongs to the MHC class I family. (348 aa)
LOC102226168Cyclin B2; Belongs to the cyclin family. (384 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (539 aa)
LOC102229128Ig-like domain-containing protein; Belongs to the MHC class I family. (361 aa)
rbl1Retinoblastoma-like 1 (p107). (1055 aa)
LOC102219761Ig-like domain-containing protein; Belongs to the MHC class I family. (358 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
cdk1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (325 aa)
ccnb3Cyclin B3; Belongs to the cyclin family. (431 aa)
LOC102235425Uncharacterized protein. (726 aa)
LOC102221799Protein kinase domain-containing protein. (1350 aa)
VDAC2Voltage dependent anion channel 2. (283 aa)
LOC102220374Myelocytomatosis oncogene homolog. (355 aa)
LOC102217271TRAF3 interacting protein 2-like. (439 aa)
gadd45gGrowth arrest and DNA-damage-inducible, gamma a. (159 aa)
LOC102221885Mitogen-activated protein kinase kinase 6. (381 aa)
nfatc3Nuclear factor of activated T cells 3a. (1092 aa)
LOC102237234Uncharacterized protein. (119 aa)
pik3r1Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (727 aa)
LOC102217080Si:ch211-160o17.4. (1145 aa)
lin54Lin-54 DREAM MuvB core complex component. (796 aa)
LOC102233918Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
LOC102226157Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1152 aa)
LOC102217443Ig-like domain-containing protein. (395 aa)
LOC102229527Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (325 aa)
LOC102231047Mitogen-activated protein kinase. (360 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (394 aa)
foxm1Forkhead box M1. (658 aa)
LOC102225479Ig-like domain-containing protein; Belongs to the MHC class I family. (381 aa)
LOC102220939Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (297 aa)
Sqstm1Uncharacterized protein. (96 aa)
PPP3CASerine/threonine-protein phosphatase. (534 aa)
pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
LOC102221373Cyclin D3; Belongs to the cyclin family. (316 aa)
LOC102223055Zgc:114130. (430 aa)
LOC102227133Uncharacterized protein; Belongs to the peptidase C2 family. (700 aa)
LOC102234824Ribosomal_L7Ae domain-containing protein. (157 aa)
LOC102223722Ig-like domain-containing protein; Belongs to the MHC class I family. (360 aa)
LOC102224118Zinc finger protein 36, C3H type-like 1a. (371 aa)
pik3r3Uncharacterized protein. (473 aa)
LOC102223477Mitogen-activated protein kinase. (364 aa)
hrasHRas proto-oncogene, GTPase a. (211 aa)
LOC102237484Nuclear factor of activated T cells 1. (767 aa)
LOC102235928Serine/threonine-protein phosphatase. (511 aa)
LOC102237756TSC complex subunit 1b. (1243 aa)
LOC102225733Cyclin D2, b; Belongs to the cyclin family. (294 aa)
hipk3Homeodomain interacting protein kinase 3b. (1345 aa)
IGFBP3Insulin like growth factor binding protein 3. (285 aa)
LOC102223409Ig-like domain-containing protein; Belongs to the MHC class I family. (361 aa)
LOC102237615Fork-head domain-containing protein. (635 aa)
LOC102234512Ras homolog, mTORC1 binding like 1. (223 aa)
LOC102228793Cyclin-dependent kinase inhibitor 1D. (178 aa)
LOC102237032Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (511 aa)
lin52Lin-52 DREAM MuvB core complex component. (112 aa)
LOC102233529Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (335 aa)
ets1V-ets avian erythroblastosis virus E26 oncogene homolog 1. (485 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (342 aa)
map2k2Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
e2f3E2F transcription factor 3. (446 aa)
mcuMitochondrial calcium uniporter. (467 aa)
LOC102223924Ig-like domain-containing protein; Belongs to the MHC class I family. (338 aa)
LOC102231514Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (598 aa)
LOC102232504Non-specific serine/threonine protein kinase. (503 aa)
pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
slc25a4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa)
ppidPeptidylprolyl isomerase D. (373 aa)
rad1RAD1 homolog (S. pombe). (289 aa)
rb1Retinoblastoma susceptibility protein. (912 aa)
fbxw11F-box and WD repeat domain containing 11a. (562 aa)
LOC102220021Ig-like domain-containing protein; Belongs to the MHC class I family. (351 aa)
LOC102223985Ig-like domain-containing protein; Belongs to the MHC class I family. (338 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
LOC102217432Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (102 aa)
zfp36l2Zinc finger protein 36, C3H type-like 2. (404 aa)
LOC102233259C-X-C motif chemokine. (104 aa)
nfatc2Nuclear factor of activated T cells 2a. (891 aa)
ppp3r1Protein phosphatase 3 regulatory subunit B, alpha. (170 aa)
LOC102221188Ig-like domain-containing protein; Belongs to the MHC class I family. (339 aa)
GADD45B-2Growth arrest and DNA damage inducible beta. (153 aa)
LOC102233752Mitogen-activated protein kinase. (435 aa)
foxo1Forkhead box O1 a. (663 aa)
LOC102231182Serine/threonine-protein phosphatase. (522 aa)
LOC102237954Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
mapkapk2MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily. (376 aa)
LOC102229803Serine/threonine-protein phosphatase. (514 aa)
ppp1ccSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (333 aa)
LOC102226857RAS related. (197 aa)
LOC102233436Uncharacterized protein. (466 aa)
ENSXMAP00000036885E2F_TDP domain-containing protein. (102 aa)
LOC102231001Voltage-dependent anion channel 2. (306 aa)
gadd45aGrowth arrest and DNA-damage-inducible, alpha, a. (162 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
LOC102222719Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
LOC102232717Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
rassf5Ras association domain family member 5. (536 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ENSXMAP00000041178E2F transcription factor 5. (149 aa)
LOC102217177Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
lin37Lin-37 DREAM MuvB core complex component. (241 aa)
LOC102223660Ig-like domain-containing protein; Belongs to the MHC class I family. (351 aa)
LOC102225439Fork-head domain-containing protein. (602 aa)
Your Current Organism:
Xiphophorus maculatus
NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish
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