STRINGSTRING
CED71232.1 CED71232.1 CED71231.1 CED71231.1 CED71211.1 CED71211.1 murQ murQ mrdA mrdA mrdB-2 mrdB-2 rlpA rlpA dacA dacA mltF mltF mltA mltA slt slt dacB dacB exoI exoI mrcB mrcB ampD ampD murC murC murG murG ftsW ftsW murD murD mraY mraY murF murF murE murE lpoA lpoA uppP uppP mrcA mrcA amiB amiB CED70136.1 CED70136.1 CED57845.1 CED57845.1 chb chb vtsA vtsA CED57620.1 CED57620.1 CED57566.1 CED57566.1 CED57528.1 CED57528.1 CED57409.1 CED57409.1 CED57231.1 CED57231.1 nagZ nagZ anmK anmK mrdB mrdB pbpC pbpC CED56949.1 CED56949.1 CED56721.1 CED56721.1 mepA mepA glmU glmU murI murI murB murB mpl mpl murA murA mviN mviN uppS uppS mltD mltD mltG mltG CED71885.1 CED71885.1 mipA mipA chiA chiA CED71725.1 CED71725.1 CED71603.1 CED71603.1 CED71560.1 CED71560.1 CED71417.1 CED71417.1 CED71336.1 CED71336.1 nagK nagK
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CED71232.1Putative membrane associated peptidase. (182 aa)
CED71231.1Putative peptidoglycan binding protein. (480 aa)
CED71211.1Putative lipoprotein. (196 aa)
murQN-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. (298 aa)
mrdAPenicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (624 aa)
mrdB-2Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (373 aa)
rlpARare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (269 aa)
dacAPenicillin-binding protein 5 precursor (D-alanyl-D-alanin carboxypeptidase fraction A); Belongs to the peptidase S11 family. (391 aa)
mltFMembrane-bound transglycosylase; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. (497 aa)
mltAMembrane-bound lytic murein transglycosylase A precursor. (366 aa)
sltSoluble lytic murein transglycosylase precursor. (644 aa)
dacBD-alanyl-D-alanine carboxypeptidase. (468 aa)
exoIBeta-hexosaminidase (beta-N-acetylglucosaminidase). (634 aa)
mrcBPenicillin-binding protein transpeptidase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (791 aa)
ampDAmpD protein (N-acetylmuramoyl-L-alanine amidase). (183 aa)
murCUDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (487 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (354 aa)
ftsWCell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (400 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (441 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide-transfera se; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa)
murFUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-ala nine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (452 aa)
murEUDP-N-acetylmuramoylalanyl-D-glutamate--2,6-dia minopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (493 aa)
lpoAPutative lipoprotein LppC; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family. (603 aa)
uppPUndecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (267 aa)
mrcAPenicillin-binding protein 1A. (830 aa)
amiBN-acetylmuramoyl-L-alanine amidase. (577 aa)
CED70136.1Putative beta-N-acetylhexosaminidase. (815 aa)
CED57845.1Putative lipoprotein. (130 aa)
chbN,N'-diacetylchitobiase (chitobiase). (881 aa)
vtsAPutative type VI secretion protein, D-alanine-D-alanine ligase VtsA; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (384 aa)
CED57620.1Putative lipoprotein. (200 aa)
CED57566.1Putative exported protein. (302 aa)
CED57528.1Putative uncharacterized protein. (215 aa)
CED57409.1Putative membrane protein. (289 aa)
CED57231.1D-alanine--D-alanine ligase. (246 aa)
nagZBeta-hexosaminidase (beta-N-acetylhexosaminidase); Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (331 aa)
anmKanhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (367 aa)
mrdBRod shape-determining protein roda; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (359 aa)
pbpCPenicillin-binding protein 1C. (733 aa)
CED56949.1Putative transglycosylase; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. In the N-terminal section; belongs to the bacterial solute- binding protein 3 family. (472 aa)
CED56721.1Putative uncharacterized protein. (738 aa)
mepAPenicillin-insensitive murein endopeptidase; Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus. (273 aa)
glmUBifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (453 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (262 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (349 aa)
mplUDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelat ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (449 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (422 aa)
mviNVirulence factor MviN homolog; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (519 aa)
uppSUndecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (257 aa)
mltDMembrane-bound lytic murein transglycosylase D precursor. (521 aa)
mltGAminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (336 aa)
CED71885.1Putative lytic murein transglycosylase. (324 aa)
mipAPutative MltA-interacting protein MipA. (252 aa)
chiAChitinase. (845 aa)
CED71725.1Putative MltA-interacting protein. (440 aa)
CED71603.1Putative uncharacterized protein. (179 aa)
CED71560.1Lysozyme. (175 aa)
CED71417.1Soluble lytic murein transglycosylase precursor. (639 aa)
CED71336.1Chitinase. (569 aa)
nagKN-acetyl-d-glucosamine kinase; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. (303 aa)
Your Current Organism:
Aliivibrio wodanis
NCBI taxonomy Id: 80852
Other names: A. wodanis, ATCC BAA-104, Aliivibrio wodanis (Lunder et al. 2000) Urbanczyk et al. 2007, DSM 22225, LMG 24053, LMG:24053, NCIMB 13582, Vibrio wodanis, Vibrio wodanis Lunder et al. 2000, strain NVI 88/441
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