STRINGSTRING
fre fre spoT spoT pyrE pyrE pyrI pyrI pyrB pyrB trmA trmA fldB fldB relA relA mazG mazG pyrG pyrG purD purD purH purH purA purA gpt gpt ndk ndk purN purN purM purM upp upp MVIS_0734 MVIS_0734 guaB guaB guaA guaA carA carA carB carB purL purL MVIS_0917 MVIS_0917 MVIS_1008 MVIS_1008 xpt xpt MVIS_1125 MVIS_1125 guaC guaC MVIS_1230 MVIS_1230 nrdG nrdG nrdD nrdD tmk-2 tmk-2 cpdB cpdB udp udp adk adk gsk gsk purT purT pyrD pyrD MVIS_2162 MVIS_2162 add add MVIS_2216 MVIS_2216 purC purC dcd dcd udk udk cdd cdd pyrP pyrP ppnP ppnP tdk tdk pyrF pyrF nrdA nrdA nrdB nrdB MVIS_2646 MVIS_2646 apt apt add-2 add-2 folD folD purF purF pyrD-2 pyrD-2 purB purB MVIS_3399 MVIS_3399 pyrC pyrC nutA nutA nutA-2 nutA-2 glyA glyA hpt hpt deoD deoD MVIS_3868 MVIS_3868 purE purE
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
freNAD(P)H-flavin reductase. (229 aa)
spoTGuanosine-3',5'-bisbis(diphosphate) 3'-pyrophosphydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (706 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa)
pyrIAspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase. (153 aa)
pyrBAspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa)
trmAtRNA (uracil-5)-methyltransferase; Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA). (366 aa)
fldBFlavodoxin 2; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. (173 aa)
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (748 aa)
mazGNutritional stress response regulator. (264 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (429 aa)
purHBifunctional purine biosynthesis protein PurH. (530 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
gptXanthine phosphoribosyltransferase (xanthine-guanin phosphoribosyltransferase); Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (153 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (215 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (346 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa)
MVIS_0734Xanthine/uracil permease. (463 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
guaAGMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. (526 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (381 aa)
carBCarbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1072 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1297 aa)
MVIS_0917Glutamine amidotransferase. (239 aa)
MVIS_1008Haloacid dehalogenase-like hydrolase. (225 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (187 aa)
MVIS_1125Permease. (441 aa)
guaCGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (346 aa)
MVIS_1230RelA/SpoT protein. (360 aa)
nrdGAnaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (173 aa)
nrdDAnaerobic ribonucleoside-triphosphate reductase. (711 aa)
tmk-2Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (194 aa)
cpdB2',3'-cyclic-nucleotide 2'-phosphodiesterase; Belongs to the 5'-nucleotidase family. (655 aa)
udpUridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (255 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
gskInosine-guanosine kinase. (433 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (393 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa)
MVIS_2162Putative phosphatase, SurE family. (315 aa)
addAdenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (335 aa)
MVIS_22165'-nucleotidase; Belongs to the 5'-nucleotidase family. (563 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (367 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (200 aa)
udkUridine kinase. (214 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (302 aa)
pyrPUracil permease. (417 aa)
ppnPUPF0345 protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (93 aa)
tdkThymidine kinase. (193 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (233 aa)
nrdARibonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (757 aa)
nrdBRibonucleoside-diphosphate reductase 1 subunit beta. (376 aa)
MVIS_2646Ferredoxin. (91 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (181 aa)
add-2Adenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (331 aa)
folDBifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (504 aa)
pyrD-2Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (400 aa)
purBAdenylosuccinate lyase (adenylosuccinase); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (455 aa)
MVIS_3399Putative metal dependent phosphohydrolase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (192 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (343 aa)
nutA5'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. (555 aa)
nutA-25'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. (549 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
hptHypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (177 aa)
deoDPurine nucleoside phosphorylase. (237 aa)
MVIS_3868Putative uncharacterized lysine decarboxylase. (453 aa)
purEAIR carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa)
Your Current Organism:
Moritella viscosa
NCBI taxonomy Id: 80854
Other names: ATCC BAA-105, M. viscosa, Moritella viscosa (Lunder et al. 2000) Benediktsdottir et al. 2000, NCIMB 13584, Vibrio viscosus, Vibrio viscosus Lunder et al. 2000, strain NVI 88/478
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