27 items (Oryzias latipes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
	Fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (159 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
	klb	Klotho beta. (1045 aa)
	LOC101161650	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (157 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	sos2	Son of sevenless homolog 2 (Drosophila). (1323 aa)
	fgfr2	Fibroblast growth factor receptor. (832 aa)
	LOC100049521	Fibroblast growth factor receptor 4. (1075 aa)
	fgfr1	Fibroblast growth factor receptor. (833 aa)
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (263 aa)
	fgfr3	Fibroblast growth factor receptor. (820 aa)
	LCT	Lactase. (1849 aa)
	fgf20b	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	LOC101165069	Fibroblast growth factor receptor like 1a. (494 aa)
	LOC101162992	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
	ENSORLP00000032568	Fibroblast growth factor binding protein 1b. (196 aa)
	fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	fgf18	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	FGFRL1	Fibroblast growth factor receptor like 1. (540 aa)
	fgf10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (250 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	fgf20a	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
	frs2	Fibroblast growth factor receptor substrate 2b. (526 aa)
	LOC101155126	Fibroblast growth factor receptor. (740 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000032568	Fgf1	ENSORLP00000032568	ENSORLP00000001852	Fibroblast growth factor binding protein 1b.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.750
ENSORLP00000032568	LOC101161650	ENSORLP00000032568	ENSORLP00000007561	Fibroblast growth factor binding protein 1b.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.750
ENSORLP00000032568	LOC101162992	ENSORLP00000032568	ENSORLP00000030909	Fibroblast growth factor binding protein 1b.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.603
ENSORLP00000032568	fgf10	ENSORLP00000032568	ENSORLP00000040733	Fibroblast growth factor binding protein 1b.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.603
ENSORLP00000032568	fgf16	ENSORLP00000032568	ENSORLP00000007650	Fibroblast growth factor binding protein 1b.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.515
ENSORLP00000032568	fgf18	ENSORLP00000032568	ENSORLP00000038417	Fibroblast growth factor binding protein 1b.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.637
ENSORLP00000032568	fgf20a	ENSORLP00000032568	ENSORLP00000042676	Fibroblast growth factor binding protein 1b.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.515
ENSORLP00000032568	fgf20b	ENSORLP00000032568	ENSORLP00000025766	Fibroblast growth factor binding protein 1b.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.515
ENSORLP00000032568	fgf3	ENSORLP00000032568	ENSORLP00000000370	Fibroblast growth factor binding protein 1b.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.757
ENSORLP00000032568	fgf4	ENSORLP00000032568	ENSORLP00000000362	Fibroblast growth factor binding protein 1b.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.637
ENSORLP00000032568	fgf5	ENSORLP00000032568	ENSORLP00000038193	Fibroblast growth factor binding protein 1b.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.637
ENSORLP00000032568	fgf7	ENSORLP00000032568	ENSORLP00000002929	Fibroblast growth factor binding protein 1b.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.819
ENSORLP00000032568	fgf8	ENSORLP00000032568	ENSORLP00000042553	Fibroblast growth factor binding protein 1b.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.636
FGFRL1	Fgf1	ENSORLP00000039931	ENSORLP00000001852	Fibroblast growth factor receptor like 1.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.640
FGFRL1	LCT	ENSORLP00000039931	ENSORLP00000022648	Fibroblast growth factor receptor like 1.	Lactase.	0.453
FGFRL1	LOC101161650	ENSORLP00000039931	ENSORLP00000007561	Fibroblast growth factor receptor like 1.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.640
FGFRL1	LOC101162992	ENSORLP00000039931	ENSORLP00000030909	Fibroblast growth factor receptor like 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.630
FGFRL1	fgf10	ENSORLP00000039931	ENSORLP00000040733	Fibroblast growth factor receptor like 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.630
FGFRL1	fgf16	ENSORLP00000039931	ENSORLP00000007650	Fibroblast growth factor receptor like 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.631
FGFRL1	fgf18	ENSORLP00000039931	ENSORLP00000038417	Fibroblast growth factor receptor like 1.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.721