(35 nodes) Mixed, incl. Melanin biosynthesis, and Sodium/potassium/calcium exchanger network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101174615	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (570 aa)
	slc45a1	Solute carrier family 45 member 1. (781 aa)
	tyrp1	Tyrosinase related protein 1. (521 aa)
	trafd1	TRAF-type zinc finger domain containing 1. (586 aa)
	slc45a2	Uncharacterized protein. (576 aa)
	kirrel2	Kirre like nephrin family adhesion molecule 3, like. (753 aa)
	LOC101172077	Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (685 aa)
	LOC101160600	Uncharacterized protein; Belongs to the histidine acid phosphatase family. (412 aa)
	herc3	HECT and RLD domain containing E3 ubiquitin protein ligase 3. (1047 aa)
	tspan10	Tetraspanin. (325 aa)
	MLANA	Uncharacterized protein. (120 aa)
	slc2a11b	Solute carrier family 2 member 11b; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (511 aa)
	BCO2	Beta-carotene oxygenase 2b. (510 aa)
	foxl1	Forkhead box L1. (326 aa)
	tfe3	Transcription factor binding to IGHM enhancer 3b. (512 aa)
	pmel	Premelanosome protein a. (779 aa)
	LOC101158436	Transcription factor EB. (511 aa)
	FOXD2	Fork-head domain-containing protein. (361 aa)
	BEST3	Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (642 aa)
	dct	Dopachrome tautomerase. (511 aa)
	slc2a11	Solute carrier family 2 member 11a; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
	SLC24A1	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (760 aa)
	gchfr	GTP cyclohydrolase I feedback regulator. (99 aa)
	MITF	Melanocyte inducing transcription factor b. (511 aa)
	LOC101161292	Tyrosinase-related protein 1b. (540 aa)
	plppr5	Phospholipid phosphatase related 5b. (356 aa)
	ENSORLP00000034563	Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (265 aa)
	LOC101163362	CDC42 effector protein (Rho GTPase binding) 1a. (383 aa)
	LOC101163732	Microphthalmia-associated transcription factor 2 isoform m. (406 aa)
	ENSORLP00000037699	Uncharacterized protein. (1006 aa)
	LOC101168423	GTP cyclohydrolase 1. (257 aa)
	MAF	MAF bZIP transcription factor; Belongs to the bZIP family. (337 aa)
	best2	Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (605 aa)
	slc24a5	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (514 aa)
	LOC101166495	Solute carrier family 45 member 4b. (799 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCO2	slc2a11	ENSORLP00000012670	ENSORLP00000024823	Beta-carotene oxygenase 2b.	Solute carrier family 2 member 11a; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.521
BCO2	slc45a2	ENSORLP00000012670	ENSORLP00000008198	Beta-carotene oxygenase 2b.	Uncharacterized protein.	0.411
ENSORLP00000037699	LOC101158436	ENSORLP00000037699	ENSORLP00000019871	Uncharacterized protein.	Transcription factor EB.	0.803
ENSORLP00000037699	LOC101163732	ENSORLP00000037699	ENSORLP00000037247	Uncharacterized protein.	Microphthalmia-associated transcription factor 2 isoform m.	0.803
ENSORLP00000037699	MITF	ENSORLP00000037699	ENSORLP00000033348	Uncharacterized protein.	Melanocyte inducing transcription factor b.	0.803
ENSORLP00000037699	tfe3	ENSORLP00000037699	ENSORLP00000017722	Uncharacterized protein.	Transcription factor binding to IGHM enhancer 3b.	0.901
LOC101158436	ENSORLP00000037699	ENSORLP00000019871	ENSORLP00000037699	Transcription factor EB.	Uncharacterized protein.	0.803
LOC101158436	LOC101163732	ENSORLP00000019871	ENSORLP00000037247	Transcription factor EB.	Microphthalmia-associated transcription factor 2 isoform m.	0.883
LOC101158436	MITF	ENSORLP00000019871	ENSORLP00000033348	Transcription factor EB.	Melanocyte inducing transcription factor b.	0.879
LOC101158436	tfe3	ENSORLP00000019871	ENSORLP00000017722	Transcription factor EB.	Transcription factor binding to IGHM enhancer 3b.	0.889
LOC101161292	LOC101163732	ENSORLP00000033423	ENSORLP00000037247	Tyrosinase-related protein 1b.	Microphthalmia-associated transcription factor 2 isoform m.	0.643
LOC101161292	MITF	ENSORLP00000033423	ENSORLP00000033348	Tyrosinase-related protein 1b.	Melanocyte inducing transcription factor b.	0.619
LOC101161292	MLANA	ENSORLP00000033423	ENSORLP00000009473	Tyrosinase-related protein 1b.	Uncharacterized protein.	0.723
LOC101161292	dct	ENSORLP00000033423	ENSORLP00000022234	Tyrosinase-related protein 1b.	Dopachrome tautomerase.	0.918
LOC101161292	pmel	ENSORLP00000033423	ENSORLP00000018803	Tyrosinase-related protein 1b.	Premelanosome protein a.	0.740
LOC101161292	slc24a5	ENSORLP00000033423	ENSORLP00000045188	Tyrosinase-related protein 1b.	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.523
LOC101161292	slc45a1	ENSORLP00000033423	ENSORLP00000005259	Tyrosinase-related protein 1b.	Solute carrier family 45 member 1.	0.526
LOC101161292	slc45a2	ENSORLP00000033423	ENSORLP00000008198	Tyrosinase-related protein 1b.	Uncharacterized protein.	0.704
LOC101161292	tyrp1	ENSORLP00000033423	ENSORLP00000005420	Tyrosinase-related protein 1b.	Tyrosinase related protein 1.	0.913
LOC101163732	ENSORLP00000037699	ENSORLP00000037247	ENSORLP00000037699	Microphthalmia-associated transcription factor 2 isoform m.	Uncharacterized protein.	0.803