(59 nodes) Histone deacetylase complex, and HDACs deacetylate histones network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101167110	GATA zinc finger domain containing 2Ab. (651 aa)
	rcor3	REST corepressor 3. (606 aa)
	LOC101169275	MRG domain-containing protein. (335 aa)
	LOC101155869	Histone deacetylase 12. (407 aa)
	hmg20b	High mobility group 20B. (292 aa)
	brms1	BRMS1 transcriptional repressor and anoikis regulator. (273 aa)
	rcor2	REST corepressor 2. (538 aa)
	LOC101174845	Chromodomain helicase DNA binding protein 4a. (1950 aa)
	LOC101167742	Chromodomain helicase DNA binding protein 3. (1603 aa)
	hdac10	Histone deacetylase 10. (703 aa)
	H2M348_ORYLA	Tudor-knot domain-containing protein. (682 aa)
	mta3	Metastasis associated 1 family, member 3. (702 aa)
	LOC101172976	SIN3-HDAC complex associated factor. (274 aa)
	gatad2b	GATA zinc finger domain containing 2B. (652 aa)
	mta1	Metastasis associated 1. (680 aa)
	mta2	Metastasis associated 1 family, member 2. (668 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (860 aa)
	phf12	PHD finger protein 12b. (1005 aa)
	LOC101155594	Si:ch73-60h1.1. (505 aa)
	phf21a	PHD finger protein 21Ab. (827 aa)
	LOC101163357	Uncharacterized protein. (244 aa)
	wdr73	Uncharacterized protein. (389 aa)
	LOC101173502	Uncharacterized protein. (741 aa)
	sap130	Sin3A-associated protein a. (1053 aa)
	sap30l	Sap30-like. (178 aa)
	aire	Autoimmune regulator. (424 aa)
	LOC101172488	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (958 aa)
	LOC101156710	Retinoblastoma binding protein 4, like. (481 aa)
	chd5	Uncharacterized protein. (1782 aa)
	brms1l	Uncharacterized protein. (291 aa)
	ing1	Inhibitor of growth protein. (304 aa)
	rcor1	REST corepressor 1. (434 aa)
	rest	RE1-silencing transcription factor. (871 aa)
	hdac8	Histone deacetylase 8. (374 aa)
	ENSORLP00000026680	Uncharacterized protein. (800 aa)
	LOC101172482	Methyl-CpG binding domain protein 3a. (350 aa)
	sin3a	SIN3 transcription regulator family member Aa. (1274 aa)
	LOC110017569	SIN3-HDAC complex associated factor, like. (230 aa)
	chd4	Uncharacterized protein. (1969 aa)
	ENSORLP00000029602	Integrase catalytic domain-containing protein. (732 aa)
	LOC101157017	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1114 aa)
	sin3b	SIN3 transcription regulator family member B. (1264 aa)
	hdac9	Histone deacetylase 9b. (668 aa)
	LOC101168266	Methyl-CpG binding domain protein 2. (386 aa)
	ENSORLP00000034331	Uncharacterized protein. (914 aa)
	ENSORLP00000034863	Integrase catalytic domain-containing protein. (513 aa)
	hdac5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1117 aa)
	hmg20a	High mobility group 20A. (320 aa)
	ENSORLP00000039328	annotation not available (354 aa)
	suds3	SDS3 homolog, SIN3A corepressor complex component. (336 aa)
	LOC101163723	SIN3 transcription regulator family member Ab. (1292 aa)
	LOC101155279	AT rich interactive domain 5A (MRF1-like). (565 aa)
	ENSORLP00000042217	Integrase catalytic domain-containing protein. (463 aa)
	arid4b	Translocase of outer mitochondrial membrane 20. (1289 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1077 aa)
	PHF21B	PHD finger protein 21B. (450 aa)
	LOC101161599	BRMS1 like transcriptional repressor b. (324 aa)
	Arid4a	Tudor domain-containing protein. (324 aa)
	LOC101167186	Methyl CpG binding protein 2. (1004 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Arid4a	ENSORLP00000026680	ENSORLP00000044983	ENSORLP00000026680	Tudor domain-containing protein.	Uncharacterized protein.	0.618
Arid4a	ENSORLP00000029602	ENSORLP00000044983	ENSORLP00000029602	Tudor domain-containing protein.	Integrase catalytic domain-containing protein.	0.618
Arid4a	ENSORLP00000034331	ENSORLP00000044983	ENSORLP00000034331	Tudor domain-containing protein.	Uncharacterized protein.	0.618
Arid4a	ENSORLP00000034863	ENSORLP00000044983	ENSORLP00000034863	Tudor domain-containing protein.	Integrase catalytic domain-containing protein.	0.618
Arid4a	ENSORLP00000039328	ENSORLP00000044983	ENSORLP00000039328	Tudor domain-containing protein.	annotation not available	0.618
Arid4a	ENSORLP00000042217	ENSORLP00000044983	ENSORLP00000042217	Tudor domain-containing protein.	Integrase catalytic domain-containing protein.	0.618
Arid4a	H2M348_ORYLA	ENSORLP00000044983	ENSORLP00000012849	Tudor domain-containing protein.	Tudor-knot domain-containing protein.	0.966
Arid4a	HDAC4	ENSORLP00000044983	ENSORLP00000043738	Tudor domain-containing protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.829
Arid4a	LOC101155869	ENSORLP00000044983	ENSORLP00000004750	Tudor domain-containing protein.	Histone deacetylase 12.	0.829
Arid4a	LOC101156710	ENSORLP00000044983	ENSORLP00000021495	Tudor domain-containing protein.	Retinoblastoma binding protein 4, like.	0.990
Arid4a	LOC101157017	ENSORLP00000044983	ENSORLP00000030146	Tudor domain-containing protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.829
Arid4a	LOC101161599	ENSORLP00000044983	ENSORLP00000044674	Tudor domain-containing protein.	BRMS1 like transcriptional repressor b.	0.985
Arid4a	LOC101163357	ENSORLP00000044983	ENSORLP00000019083	Tudor domain-containing protein.	Uncharacterized protein.	0.630
Arid4a	LOC101163723	ENSORLP00000044983	ENSORLP00000039938	Tudor domain-containing protein.	SIN3 transcription regulator family member Ab.	0.907
Arid4a	LOC101167110	ENSORLP00000044983	ENSORLP00000000886	Tudor domain-containing protein.	GATA zinc finger domain containing 2Ab.	0.595
Arid4a	LOC101167186	ENSORLP00000044983	ENSORLP00000045247	Tudor domain-containing protein.	Methyl CpG binding protein 2.	0.660
Arid4a	LOC101167742	ENSORLP00000044983	ENSORLP00000008921	Tudor domain-containing protein.	Chromodomain helicase DNA binding protein 3.	0.721
Arid4a	LOC101168266	ENSORLP00000044983	ENSORLP00000034270	Tudor domain-containing protein.	Methyl-CpG binding domain protein 2.	0.630
Arid4a	LOC101172482	ENSORLP00000044983	ENSORLP00000026781	Tudor domain-containing protein.	Methyl-CpG binding domain protein 3a.	0.630
Arid4a	LOC101172488	ENSORLP00000044983	ENSORLP00000020522	Tudor domain-containing protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.829