(45 nodes) One carbon pool by folate, and Glycine, serine and threonine metabolism network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	lipt1	Lipoyltransferase 1. (380 aa)
	Psat1	Phosphoserine aminotransferase 1. (306 aa)
	ppat	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (504 aa)
	paics	AIRC domain-containing protein. (999 aa)
	SHMT2	Serine hydroxymethyltransferase 2. (528 aa)
	LOC101162942	Zgc:174895. (200 aa)
	alas1	5-aminolevulinate synthase. (623 aa)
	dhfr	Dihydrofolate reductase. (189 aa)
	shmt2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (501 aa)
	lias	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (409 aa)
	mthfd2	Uncharacterized protein. (338 aa)
	gart	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1007 aa)
	dao	D-amino-acid oxidase, tandem duplicate 2. (345 aa)
	LOC101155190	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (175 aa)
	LOC101174660	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (902 aa)
	sardh	Sarcosine dehydrogenase. (916 aa)
	gcat	Glycine C-acetyltransferase. (427 aa)
	LOC101170713	Threonine aldolase 1. (415 aa)
	tyms	Thymidylate synthetase. (288 aa)
	pipox	Pipecolic acid oxidase. (388 aa)
	shmt1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (482 aa)
	mthfd1l	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (966 aa)
	pdpr	Pyruvate dehydrogenase phosphatase regulatory subunit. (895 aa)
	LOC101162880	Zgc:153901. (407 aa)
	H2MLV1_ORYLA	Uncharacterized protein. (141 aa)
	LOC101169257	L-threonine dehydrogenase. (374 aa)
	LOC101161149	Zgc:153031. (197 aa)
	LOC101174548	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (881 aa)
	phgdh	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (577 aa)
	fpgs	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (576 aa)
	mthfr	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (657 aa)
	LOC101174079	Alanine--glyoxylate and serine--pyruvate aminotransferase a. (461 aa)
	mtr	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1270 aa)
	LOC101156637	Glycine cleavage system protein H (aminomethyl carrier), b. (203 aa)
	gnmt	Glycine N-methyltransferase. (295 aa)
	gldc	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1031 aa)
	adsl	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (481 aa)
	amt	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (414 aa)
	mthfsd	Methenyltetrahydrofolate synthetase domain containing. (467 aa)
	atic	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (747 aa)
	LOC100049501	5-aminolevulinate synthase. (591 aa)
	ENSORLP00000040334	Uncharacterized protein. (273 aa)
	aldh1l2	Aldehyde dehydrogenase 1 family, member L2; Belongs to the aldehyde dehydrogenase family. (988 aa)
	lipt2	Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. Belongs to the LipB family. (224 aa)
	LOC101165643	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (348 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000040334	LOC101155190	ENSORLP00000040334	ENSORLP00000011711	Uncharacterized protein.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.437
ENSORLP00000040334	LOC101156637	ENSORLP00000040334	ENSORLP00000027593	Uncharacterized protein.	Glycine cleavage system protein H (aminomethyl carrier), b.	0.437
ENSORLP00000040334	LOC101161149	ENSORLP00000040334	ENSORLP00000020523	Uncharacterized protein.	Zgc:153031.	0.501
ENSORLP00000040334	LOC101162880	ENSORLP00000040334	ENSORLP00000019249	Uncharacterized protein.	Zgc:153901.	0.649
ENSORLP00000040334	LOC101165643	ENSORLP00000040334	ENSORLP00000045156	Uncharacterized protein.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.753
ENSORLP00000040334	LOC101174660	ENSORLP00000040334	ENSORLP00000011903	Uncharacterized protein.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.474
ENSORLP00000040334	Psat1	ENSORLP00000040334	ENSORLP00000002088	Uncharacterized protein.	Phosphoserine aminotransferase 1.	0.516
ENSORLP00000040334	SHMT2	ENSORLP00000040334	ENSORLP00000004789	Uncharacterized protein.	Serine hydroxymethyltransferase 2.	0.706
ENSORLP00000040334	adsl	ENSORLP00000040334	ENSORLP00000029262	Uncharacterized protein.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.613
ENSORLP00000040334	aldh1l2	ENSORLP00000040334	ENSORLP00000040437	Uncharacterized protein.	Aldehyde dehydrogenase 1 family, member L2; Belongs to the aldehyde dehydrogenase family.	0.474
ENSORLP00000040334	amt	ENSORLP00000040334	ENSORLP00000030030	Uncharacterized protein.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.472
ENSORLP00000040334	atic	ENSORLP00000040334	ENSORLP00000033190	Uncharacterized protein.	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	0.773
ENSORLP00000040334	dhfr	ENSORLP00000040334	ENSORLP00000006371	Uncharacterized protein.	Dihydrofolate reductase.	0.502
ENSORLP00000040334	fpgs	ENSORLP00000040334	ENSORLP00000022891	Uncharacterized protein.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.754
ENSORLP00000040334	gart	ENSORLP00000040334	ENSORLP00000007887	Uncharacterized protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.993
ENSORLP00000040334	gldc	ENSORLP00000040334	ENSORLP00000029139	Uncharacterized protein.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.724
ENSORLP00000040334	mthfd2	ENSORLP00000040334	ENSORLP00000007827	Uncharacterized protein.	Uncharacterized protein.	0.751
ENSORLP00000040334	mthfr	ENSORLP00000040334	ENSORLP00000023652	Uncharacterized protein.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.635
ENSORLP00000040334	mthfsd	ENSORLP00000040334	ENSORLP00000032153	Uncharacterized protein.	Methenyltetrahydrofolate synthetase domain containing.	0.728
ENSORLP00000040334	mtr	ENSORLP00000040334	ENSORLP00000026510	Uncharacterized protein.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.559