(17 nodes) One carbon pool by folate network (Oryzias latipes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SHMT2	Serine hydroxymethyltransferase 2. (528 aa)
	dhfr	Dihydrofolate reductase. (189 aa)
	shmt2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (501 aa)
	mthfd2	Uncharacterized protein. (338 aa)
	gart	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1007 aa)
	LOC101155190	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (175 aa)
	tyms	Thymidylate synthetase. (288 aa)
	shmt1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (482 aa)
	mthfd1l	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (966 aa)
	LOC101161149	Zgc:153031. (197 aa)
	LOC101174548	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (881 aa)
	fpgs	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (576 aa)
	mthfr	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (657 aa)
	mtr	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1270 aa)
	gldc	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1031 aa)
	amt	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (414 aa)
	LOC101165643	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (348 aa)

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101155190	LOC101161149	ENSORLP00000011711	ENSORLP00000020523	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Zgc:153031.	0.706
LOC101155190	LOC101165643	ENSORLP00000011711	ENSORLP00000045156	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.799
LOC101155190	LOC101174548	ENSORLP00000011711	ENSORLP00000021416	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b.	0.437
LOC101155190	SHMT2	ENSORLP00000011711	ENSORLP00000004789	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Serine hydroxymethyltransferase 2.	0.979
LOC101155190	amt	ENSORLP00000011711	ENSORLP00000030030	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.998
LOC101155190	dhfr	ENSORLP00000011711	ENSORLP00000006371	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Dihydrofolate reductase.	0.706
LOC101155190	fpgs	ENSORLP00000011711	ENSORLP00000022891	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.461
LOC101155190	gart	ENSORLP00000011711	ENSORLP00000007887	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.875
LOC101155190	gldc	ENSORLP00000011711	ENSORLP00000029139	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.999
LOC101155190	mthfd1l	ENSORLP00000011711	ENSORLP00000018107	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.437
LOC101155190	mthfd2	ENSORLP00000011711	ENSORLP00000007827	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Uncharacterized protein.	0.799
LOC101155190	mthfr	ENSORLP00000011711	ENSORLP00000023652	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.931
LOC101155190	mtr	ENSORLP00000011711	ENSORLP00000026510	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.567
LOC101155190	shmt1	ENSORLP00000011711	ENSORLP00000017275	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.979
LOC101155190	shmt2	ENSORLP00000011711	ENSORLP00000006970	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.979
LOC101155190	tyms	ENSORLP00000011711	ENSORLP00000013877	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	Thymidylate synthetase.	0.918
LOC101161149	LOC101155190	ENSORLP00000020523	ENSORLP00000011711	Zgc:153031.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.706
LOC101161149	LOC101165643	ENSORLP00000020523	ENSORLP00000045156	Zgc:153031.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.530
LOC101161149	LOC101174548	ENSORLP00000020523	ENSORLP00000021416	Zgc:153031.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b.	0.948
LOC101161149	SHMT2	ENSORLP00000020523	ENSORLP00000004789	Zgc:153031.	Serine hydroxymethyltransferase 2.	0.968